Core D: Biobank Core

核心 D：生物样本库核心

• 批准号: 9015765
• 负责人: Rodney D Newberry
• 金额: $ 28.38万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9015765
• 关键词: Basic Science; Categories; Clinical; Clinical Data; Clinical Research; Collection; Consent; Data; Data Set; Digestive System Disorders; Disease; Enrollment; Environment; Functional disorder; Gastrointestinal Diseases; Gastrointestinal tract structure; Genotype; Goals; Grant; Human; Human Resources; Individual; Institution; Institutional Review Boards; Link; Metadata; Mission; Observational Study; Outcome; Patients; Process; Protocols documentation; Publications; Qualifying; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Retrospective Studies; Specimen; Specimen Handling; Time; Training; Translating; United States; United States National Institutes of Health; Universities; Washington; biobank; cost effective; design; high throughput analysis; member; programs; prospective; repository

The Washington University DDRCC's mission is to support and promote digestive disease related research in an efficient and cost effective manner. The Biobank Core was designed to lessen barriers associated with performing human studies to rapidly promote basic and clinical research in human digestive diseases. The Biobank Core functions as both an archival repository of specimens linked with clinical metadata acquired from individuals with digestive diseases and as a program to prospectively enroll patients, collect specimens, process and store specimens, and facilitate downstream high throughput analysis to support DDRCC members' studies. The overarching aim of the Biobank Core is to promote, facilitate, and accelerate basic and clinical-translational observational studies of human digestive disease. Aim 1: Develop and maintain an archival specimen dataset linked with clinical metadata to rapidly support retrospective studies of human digestive disease by DDRCC members. Aim 2: Develop and maintain the infrastructure to support and rapidly and efficiently execute prospective observational studies in human digestive disease by DDRCC members. Aim 3: Develop and maintain the infrastructure to support large observational studies of human digestive disease across multiple institutions throughout the United States. HIGHLIGHTS - Since November 2009, the Biobank Core has expanded and promoted the infrastructure to support observational studies in human digestive disease by 1) establishing and maintaining an open IRB protocol allowing the broad collection and sharing of specimens and clinical data 2) training, and retaining personnel 3) developing pipelines to rapidly obtain quality and high throughput analysis 4) developing protocols to allow specimens and data to be efficiently shared with other institutions 5) enrolling 3900 patients and collecting over 7000 specimens from over 11 digestive related disease categories as of 4/1/2013 collected over 7,000 specimens and their derivatives linked with clinical metadata, performed extensive genotype analysis on over 1,500 patients as of 4/1/2013. We have supported 20 Washington University DDRCC investigators including 30% of the current full members of the DDRCC, with 8 ongoing prospective collections. This has resulted in 39 publications supported by the DDRCC Biobank Core and has led to 13 additional grants (8 from the NIH) submitted and/or obtained with the Biobank's support. We are participating in consortium studies in human gastrointestinal disease involving 8 other institutions throughout the United States.

华盛顿大学DDRCC的使命是支持和促进消化疾病相关研究 以有效且具有成本效益的方式。生物库核心旨在减少与之相关的障碍 进行人类研究以快速促进人类消化疾病的基本和临床研究。这 生物库核心既是与获得临床元数据相关的标本的档案存储库 从患有消化系统疾病的人以及作为前瞻性注册患者的计划，收集标本， 处理和存储标本，并促进下游高通量分析以支持DDRCC 成员的研究。生物库核心的总体目的是促进，促进和加速基本 和人类消化系统疾病的临床翻译观测研究。目标1：开发和维护 与临床元数据相关的档案标本数据集，以快速支持人类的回顾性研究 DDRCC成员的消化疾病。目标2：开发和维护基础设施以支持和 通过DDRCC快速有效地执行人类消化疾病的前瞻性观察研究 成员。目标3：开发和维护基础设施以支持人类的大型观察性研究 整个美国多个机构的消化疾病。 亮点 - 自2009年11月以来，生物库核心已扩大并促进了基础设施 通过1）建立和维持开放的IRB来支持人类消化疾病的观察性研究 协议允许广泛收集和共享标本和临床数据2）培训，并保留 人员3）开发管道以快速获得质量和高吞吐量分析4） 协议允许标本和数据有效地与其他机构共享 5）注册3900名患者，并从11种消化系统疾病中收集7000多个标本 截至2013年4月1日，类别收集了7,000多个标本，其衍生物与临床元数据相关， 截至2013年4月1日，对1,500多名患者进行了广泛的基因型分析。我们支持20 华盛顿大学DDRCC调查员，其中包括30％的DDRCC全部成员， 8正在进行的潜在收藏。这导致了DDRCC生物库支持的39个出版物 核心，并已提交了13个额外的赠款（来自NIH的8个）和/或与生物库一样获得 支持。我们正在参与人类胃肠道疾病的财团研究，涉及其他8个 美国各地的机构。