Midcareer Investigator Award in Patient-Oriented Research

以患者为导向的研究中的职业生涯中期研究员奖

• 批准号: 9108690
• 负责人: ERIKA M D'AGATA
• 金额: $ 17.65万
• 依托单位: RHODE ISLAND HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-03-15 至 2021-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9108690
• 关键词: Area; Award; Caliber; Centers for Disease Control and Prevention (U.S.); Chronic; Communicable Diseases; Development; Dialysis procedure; Discipline; Educational Status; Environment; Faculty; Foundations; Funding; Genotype; Geriatrics; Goals; Grant; Growth; Hemodialysis; Individual; Institution; Journals; Learning; Letters; Long-Term Care; Mathematics; Medicine; Mentors; Mentorship; Methodology; Mid-Career Clinical Scientist Award (K24); Midcareer Investigator Award in Patient-Oriented Research; Nephrology; Organism Strains; Outpatients; Patients; Pilot Projects; Population; Positioning Attribute; Prevention strategy; Principal Investigator; Public Health Schools; Publishing; Randomized Controlled Trials; Recruitment Activity; Research; Research Personnel; Resources; Risk; Science; Secure; Structure; Time; Training; Training Programs; United States Agency for Healthcare Research and Quality; United States National Institutes of Health; Universities; antimicrobial; career; cohort; disorder prevention; interest; mathematical model; microbial; microbiome; multi-drug resistant pathogen; next generation sequencing; novel; patient oriented research; programs; public health relevance; skills; success; transmission process

 DESCRIPTION (provided by applicant): My career goals are to continue as an investigator in patient-oriented research (POR) and to provide mentoring for beginning investigators. My research focuses on the transmission dynamics of multidrug-resistant organisms (MDRO) among hospitalized patients, residents of long term care facilities, and the chronic hemodialysis population. My research has identified key and novel aspects of MDRO transmission and has quantified the most effective prevention strategies aimed at reducing their spread. Methodologies of my POR include large cohort and randomized controlled trials, genotyping of MDRO strains and mathematical modeling. Over the past years, I have built a successful independent research program and have secured National Institute of Health (NIH), Centers for Disease Control and Prevention, and National Science Foundation funding. I have also mentored numerous fellows and junior faculty, who under my mentorship, have obtained their own funding, published in leading journals and have gone on to become independent investigators and obtain academic faculty positions. Since my research crosses several disciplines, I have mentored trainees in a variety of subspecialties, including infectious diseases nephrology, geriatrics and mathematics. This is an optimal time in my career for a K24 award as I have an active research program that focuses on the development and implementation of antimicrobial stewardship programs in long term care facilities and out-patient dialysis units. This research will allow me to provide ample opportunities for trainees to perform research. I have also recently expanded my research area to the analyses of the microbiome and the identification of specific microbial signatures that increase the risk of MDRO acquisition, and have recently submitted an R01 with Dr. Martin Blaser (co-principal investigator), who is dedicated to providing his senior mentorship in this new area of my research. The K24 will allow me the time required to dedicate myself to learning this new field, and the ongoing growth of my research agenda. Lastly, this K24 will also allow me to have protected time to dedicate to the mentoring of trainees, a key component to successful mentoring.

 描述（由应用程序提供）：我的职业目标是继续担任以患者为导向的研究（POR）的研究者，并为初学者的研究人员提供心理。我的研究重点是住院患者，长期护理设施的居民和慢性血液透析群体中多药耐药生物（MDRO）的传播动态。我的研究已经确定了MDRO传播的关键和新颖方面，并量化了旨在减少其传播的最有效的预防策略。我的POR的方法包括大型队列和随机对照试验，MDRO菌株的基因分型和数学建模。在过去的几年中，我建立了一项成功的独立研究计划，并确保了国家卫生研究院（NIH），疾病控制与预防中心以及国家科学基金会的资助。在我的心态下，我还指导了许多研究员和初级教师，他们已经获得了自己的资金，该资金发表在领先的期刊上，并继续成为独立的调查员并获得了学术教师职位。由于我的研究跨越了几个学科，因此我指导了各种专科的学员，包括传染病肾脏病，老年医学和数学。这是我职业生涯中K24奖的最佳时期，因为我拥有一项积极的研究计划，该计划重点是在长期护理设施和门诊透析单元中开发和实施抗微生物管理计划。这项研究将使我为学员提供足够的机会进行研究。我最近还将研究领域扩展到了微生物组的分析以及鉴定增加MDRO获取风险的特定微生物特征，并最近与Martin Blaser（共同利用）研究员提交了R01，他们致力于在我的研究新领域中提供高级精神。 K24将为我花时间学习这个新领域所需的时间，以及我的研究议程的持续增长。最后，这款K24还将让我有保护的时间来献给受训者的心态，这是成功心态的关键组成部分。