Vascular Interfaces for Brain Imaging and Stimulation

用于脑成像和刺激的血管接口

基本信息

批准号：
8935952
负责人：
Robert Desimone
金额：
$ 46.8万
依托单位：
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-09-26 至 2017-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8935952
关键词：
Adverse event Animals Architecture Area Biological Biological Assay Blood Vessels Blood capillaries Blood flow Brain Brain Diseases Brain imaging Cells Cephalic Chemicals Code Collaborations Data Set Deep Brain Stimulation Devices Dimensions Electric Stimulation Electrodes Electroencephalography Electronics Engineering Equilibrium Experimental Models Fiber Functional Magnetic Resonance Imaging Geometry Gliosis Health Human Image Imaging Device Implant Infection Infusion procedures Lasers Lead Measures Mechanics Medicine Methodology Methods Microfabrication Microscopic Modality Modeling Molecular Muscle Neurons Noise Operative Surgical Procedures Optics Parkinson Disease Patients Performance Phase Physics Polymers Population Property Protocols documentation Public Health Reaction Research Resolution Risk Rodent Route Scanning Scientist Signal Transduction Stents Surface System Testing Therapeutic Time Translations Treatment Efficacy Vascular System Work base blood flow measurement brain machine interface brain tissue capillary cranium design in vivo innovation knowledge of results microchip multi-electrode arrays nanowire neuroregulation neurosurgery novel prototype relating to nervous system skull implant spatiotemporal submicron tool two-photon vascular factor voltage

项目摘要

DESCRIPTION (provided by applicant): Functional MRI (fMRI), EEG, and other completely noninvasive modalities for large-scale imaging of human brain activity have pioneeringly revealed many human brain functions, but cannot reach the single-neuron, single-spike level of neural code analysis possible in animals obtained using electrodes. This is partly due to the indirect methods of observation employed (e.g., blood flow for fMRI) and due to blurring of signals over distance by the skull (e.g., for EEG). In contrast, invasive approaches such as trans-cranially implanted multi- electrode arrays can achieve single-cell, single-spike resolution, but they necessitate opening of the skull - and, for implanted arrays, damage of the brain tissue - limiting utility to a small fraction of the population, those undergoing neurosurgery for some intractable brain disorder that justifies the risk. Trans-cranially implanted arrays also degrade i performance over time due to gliosis and other brain reactions, and create vulnerabilities to infection. Vascular access offers a less-invasive, safer and more scalable means - in comparison to trans-cranial electrodes - to deliver recording devices to the vicinity of neurons buried inside the brain parenchyma. We here propose to create a vascular platform for brain imaging, stimulation, electrical recording, and molecular access, aiming for devices that will work at least in large blood vessels, and also paving the way towards capillary-resolution neural access through vasculature. Specifically, we propose to initiate a multi-institutional, collaboratie effort to design a human-applicable vascular neural interface for multiplexed neural recording and stimulation, and to carry out preliminary pilot theoretical and experimental projects to validate the basic parameters of the resulting concepts.

描述（由适用提供）：功能性MRI（fMRI），EEG和其他用于人脑活动的大规模成像的完全无创模式，已经开创性地揭示了许多人脑功能，但无法达到使用电电子的动物中可能获得的动物的单个神经元，单跨度的神经代码分析。这部分是由于携带的间接观察方法（例如，fMRI的血流）以及颅骨在距离上模糊信号（例如，脑电图）。相比之下，诸如经颅植入多电极阵列之类的侵入性方法可以实现单细胞，单尖峰分辨率，但是他们需要打开头骨 - 对于植入的阵列，脑组织的损害 - 将效用限制在一小部分人群中，那些正在接受神经外科手术的人，以证明某些棘手的脑部疾病证明了风险的合理。经颅植入的阵列还由于神经胶质变性和其他大脑反应而降低I的性能，并造成感染的脆弱性。与跨颅电气相比，血管通道提供了一种侵入性，更安全，更可扩展的手段，可将记录设备传递到脑实质内建立的神经元附近的记录设备。我们在这里建议建立一个用于大脑成像，刺激，电记录和分子访问的血管平台，目的是针对至少在大型血管中起作用的设备，并通过脉管系统铺平了沿毛细管分辨率神经元进入的道路。具体而言，我们建议启动多机构的合作努力，以设计一种可为多重神经元记录和刺激的人类适用的血管神经元界面，并进行初步的试验理论和实验项目，以验证所得概念的基本参数。