Accelerated Neuro-MRA Using Compressed Sensing and Constrained Reconstruction

使用压缩感知和约束重建加速神经 MRA

• 批准号: 8964845
• 负责人: Kevin Michael Johnson
• 金额: $ 32.94万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2019-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8964845
• 关键词: Acceleration; Agreement; Anatomy; Aneurysm; Angiography; Appearance; Arterial Fatty Streak; Atherosclerosis; Blood; Blood Vessels; Brain; Brain Aneurysms; Brain hemorrhage; Caring; Catheters; Cerebrovascular system; Clinical; Clinical Treatment; Complex; Cone; Coupled; Couples; Coupling; Data; Development; Diagnostic; Disease; Disease Marker; Dropout; Economics; Evaluation; Functional disorder; Funding; Geometry; Goals; Image; Imagery; Imaging technology; Implant; Inflammation; Inflammatory; Intracranial Aneurysm; Intracranial Atheroscleroses; Investigation; Ischemic Stroke; Lesion; Lesion by Morphology; Link; Liquid substance; Magnetic Resonance Imaging; Measures; Metals; Methods; Modeling; Monitor; Morphologic artifacts; Morphology; Motion; National Institute of Neurological Disorders and Stroke; Neurologic; Noise; Pathogenesis; Pathway interactions; Patients; Predisposition; Radial; Resolution; Roentgen Rays; Sampling; Scanning; Signal Transduction; Stenosis; Stents; Stroke; Structure; Symptoms; Techniques; Technology; Testing; Time; Validation; Vascular Diseases; Vascular remodeling; X-Ray Computed Tomography; base; contrast enhanced; contrast imaging; diagnostic accuracy; endothelial dysfunction; hemodynamics; high risk; imaging modality; improved; in vivo; innovation; insight; minimal risk; next generation; non-invasive imaging; novel; older patient; phantom model; prognostic; public health relevance; quantitative imaging; reconstruction; resilience; simulation; social; standard of care; tool; uptake

 DESCRIPTION (provided by applicant): The enormous economic and social burden of stroke demands better tools to assess the cerebrovascular system. Magnetic Resonance Imaging (MRI) is widely used in the evaluation and management of patients presenting with symptoms of stroke and is standard of care for most diagnostic neurological imaging. In the case of intact aneurysms and atherosclerotic plaques, MRI offers unique contrast mechanisms unavailable from competing technologies. In both these diseases, an interaction of the endothelial wall with hemodynamic forces exerted by blood has been established. The exact relationship between forces and subsequent vascular pathogenesis is uncertain; however, flow conditions that predispose subjects to stenosis and aneurysm formation have been identified. MRI with flow encoding (4D flow), holds potential to non-invasively probe potentially hostile hemodynamic conditions. Furthermore, endothelial status can be probed with MRI utilizing black blood imaging to visualize the uptake of exogenous contrasts. Recent MRI studies suggest a link between post-contrast arterial wall enhancement (AWE) and lesion instability, potentially indicating AWE as a measure of active inflammation and remodeling. The simultaneous depiction of hemodynamics and inflammation holds tremendous potential to improve the in-vivo characterization of diseases involving vessel wall dysfunction or active remodeling. Unfortunately, current MRI methods often suffer from signal loss due complex and turbulent flow, inadequate coverage, and limitations in spatial resolution. Furthermore, many unique MRI contrast mechanisms, such as 4D flow, are not practical for clinical imaging due to extended scan times with required resolutions for accurate quantification. This proposal suggests a next generation of accelerated imaging technology for the comprehensive evaluation of intracranial stenoses and aneurysms that will rival and surpass computed tomography (CT) through the symbiotic development of new image acquisition and constrained reconstruction methods. In particular, we aim to develop methods for robust quantitative MRA (qMRA), a multi-contrast high resolution vascular imaging paradigm. In order to achieve the required combinations of artifact reduction, spatial resolution and signal-to-noise ratio, we harness acquisition strategies utilizin novel ultra-short echo time acquisition techniques in combination with robust model based reconstruction techniques. By acquiring data more rapidly and in a more efficient manor, these strategies allow improved spatial resolution while mitigating diagnostic obscuring artifacts from the complex flow. We aim to harness these advances to into a synergistic combination of angiographic MRI with highly accelerated 4D-flow and vessel wall imaging to investigate the interactions between vascular remodeling, inflammation, and hemodynamics in intact intracranial aneurysms and atherosclerotic lesions. The ultimate goal is to observed correlations between hostile hemodynamic conditions and arterial wall enhancement utilizing non-invasive imaging, which may provide new clinical treatment paradigms and improve the management of a broad array of neurovascular diseases.

 描述（由适用提供）：中风的巨大经济和社会燃烧需要更好的工具来评估脑血管系统。磁共振成像（MRI）广泛用于评估和管理中风症状的患者，并且是大多数诊断神经系统成像的护理标准。在完整的动脉瘤和动脉粥样硬化斑块的情况下，MRI提供了竞争技术无法获得的独特对比机制。在这两种疾病中，都已经建立了内皮壁与血液动力学的相互作用。力与随后的血管发病机理之间的确切关系尚不确定。但是，已经确定了易于狭窄和动脉瘤形成的流动条件。具有流量编码的MRI（4D流）具有非侵入性探测潜在敌对血液动力学条件的潜力。此外，可以通过MRI利用黑血成像来探测内皮状态，从而可视化外源性对比的吸收。最近的MRI研究表明，对比后动脉壁增强（AWE）与病变不稳定性之间存在联系，这可能表明AWE是对主动感染和重塑的量度。血液动力学和感染的同时深度具有巨大的潜力，可以改善涉及血管壁功能障碍或主动重塑的疾病的体内表征。不幸的是，当前的MRI方法通常由于复杂和湍流，覆盖率不足以及空间分辨率的局限性而遭受信号损失。此外，由于延长的扫描时间，许多独特的MRI对比机制（例如4D流量）对于临床成像是不切实际的，并且需要精确定量分辨率。该建议建议通过对新的图像采集和约束重建方法的共生发展，将对颅内促炎和动脉瘤的全面评估进行全面评估。特别是，我们旨在开发用于鲁棒定量MRA（QMRA）的方法，这是一种多对比度高分辨率血管成像范式。为了实现减少伪影，空间分辨率和信噪比的所需组合，我们利用了获取策略Uselizin uselizin Nepbalizin Nepbal-Short ECHO ECHO ECHO ECHO TIME获取技术，并结合强大的基于模型的重建技术。通过更快地获取数据，在更有效的庄园中，这些策略可以改善空间分辨率，同时减轻复杂流量的诊断模糊伪像。我们旨在利用这些进步，使血管造影MRI与高速加速的4D流和血管壁成像的协同组合，以研究完整颅内动脉瘤和动脉粥样硬化病变的血管重塑，炎症和血液动力学之间的相互作用。最终目标是观察使用非侵入性成像的敌对血液动力学条件与动脉壁增强之间的相关性，这可能会提供新的临床治疗范式并改善广泛的神经血管疾病的管理。