Accelerated Neuro-MRA Using Compressed Sensing and Constrained Reconstruction

使用压缩感知和约束重建加速神经 MRA

• 批准号: 8964845
• 负责人: Kevin Michael Johnson
• 金额: $ 32.94万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2019-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8964845
• 关键词: Acceleration; Agreement; Anatomy; Aneurysm; Angiography; Appearance; Arterial Fatty Streak; Atherosclerosis; Blood; Blood Vessels; Brain; Brain Aneurysms; Brain hemorrhage; Caring; Catheters; Cerebrovascular system; Clinical; Clinical Treatment; Complex; Cone; Coupled; Couples; Coupling; Data; Development; Diagnostic; Disease; Disease Marker; Dropout; Economics; Evaluation; Functional disorder; Funding; Geometry; Goals; Image; Imagery; Imaging technology; Implant; Inflammation; Inflammatory; Intracranial Aneurysm; Intracranial Atheroscleroses; Investigation; Ischemic Stroke; Lesion; Lesion by Morphology; Link; Liquid substance; Magnetic Resonance Imaging; Measures; Metals; Methods; Modeling; Monitor; Morphologic artifacts; Morphology; Motion; National Institute of Neurological Disorders and Stroke; Neurologic; Noise; Pathogenesis; Pathway interactions; Patients; Predisposition; Radial; Resolution; Roentgen Rays; Sampling; Scanning; Signal Transduction; Stenosis; Stents; Stroke; Structure; Symptoms; Techniques; Technology; Testing; Time; Validation; Vascular Diseases; Vascular remodeling; X-Ray Computed Tomography; base; contrast enhanced; contrast imaging; diagnostic accuracy; endothelial dysfunction; hemodynamics; high risk; imaging modality; improved; in vivo; innovation; insight; minimal risk; next generation; non-invasive imaging; novel; older patient; phantom model; prognostic; public health relevance; quantitative imaging; reconstruction; resilience; simulation; social; standard of care; tool; uptake

 DESCRIPTION (provided by applicant): The enormous economic and social burden of stroke demands better tools to assess the cerebrovascular system. Magnetic Resonance Imaging (MRI) is widely used in the evaluation and management of patients presenting with symptoms of stroke and is standard of care for most diagnostic neurological imaging. In the case of intact aneurysms and atherosclerotic plaques, MRI offers unique contrast mechanisms unavailable from competing technologies. In both these diseases, an interaction of the endothelial wall with hemodynamic forces exerted by blood has been established. The exact relationship between forces and subsequent vascular pathogenesis is uncertain; however, flow conditions that predispose subjects to stenosis and aneurysm formation have been identified. MRI with flow encoding (4D flow), holds potential to non-invasively probe potentially hostile hemodynamic conditions. Furthermore, endothelial status can be probed with MRI utilizing black blood imaging to visualize the uptake of exogenous contrasts. Recent MRI studies suggest a link between post-contrast arterial wall enhancement (AWE) and lesion instability, potentially indicating AWE as a measure of active inflammation and remodeling. The simultaneous depiction of hemodynamics and inflammation holds tremendous potential to improve the in-vivo characterization of diseases involving vessel wall dysfunction or active remodeling. Unfortunately, current MRI methods often suffer from signal loss due complex and turbulent flow, inadequate coverage, and limitations in spatial resolution. Furthermore, many unique MRI contrast mechanisms, such as 4D flow, are not practical for clinical imaging due to extended scan times with required resolutions for accurate quantification. This proposal suggests a next generation of accelerated imaging technology for the comprehensive evaluation of intracranial stenoses and aneurysms that will rival and surpass computed tomography (CT) through the symbiotic development of new image acquisition and constrained reconstruction methods. In particular, we aim to develop methods for robust quantitative MRA (qMRA), a multi-contrast high resolution vascular imaging paradigm. In order to achieve the required combinations of artifact reduction, spatial resolution and signal-to-noise ratio, we harness acquisition strategies utilizin novel ultra-short echo time acquisition techniques in combination with robust model based reconstruction techniques. By acquiring data more rapidly and in a more efficient manor, these strategies allow improved spatial resolution while mitigating diagnostic obscuring artifacts from the complex flow. We aim to harness these advances to into a synergistic combination of angiographic MRI with highly accelerated 4D-flow and vessel wall imaging to investigate the interactions between vascular remodeling, inflammation, and hemodynamics in intact intracranial aneurysms and atherosclerotic lesions. The ultimate goal is to observed correlations between hostile hemodynamic conditions and arterial wall enhancement utilizing non-invasive imaging, which may provide new clinical treatment paradigms and improve the management of a broad array of neurovascular diseases.

 描述（由申请人提供）：中风带来的巨大经济和社会负担需要更好的工具来评估脑血管系统，磁共振成像（MRI）广泛用于评估和管理出现中风症状的患者，并且是标准护理。对于大多数诊断性神经成像，MRI 提供了竞争技术无法提供的独特对比机制，即内皮壁与血流动力学的相互作用。血液施加的力与随后的血管发病机制之间的确切关系尚不确定；然而，使用流编码（4D 流）的 MRI 已确定了导致受试者易发生狭窄和动脉瘤形成的流条件。此外，可以利用黑血成像通过 MRI 来探测内皮状态，以可视化外源造影剂的摄取情况。最近的 MRI 研究表明，造影后动脉之间存在联系。血管壁增强（AWE）和病变不稳定性，可能表明 AWE 作为活动性炎症和重塑的衡量标准，血流动力学和炎症的同时综合对于改善涉及血管壁功能障碍或主动重塑的疾病的体内特征具有巨大的潜力。当前的 MRI 方法经常因复杂和湍流、覆盖范围不足以及空间分辨率的限制而遭受信号损失。此外，由于所需分辨率的扫描时间较长，许多独特的 MRI 对比机制（例如 4D 流）对于临床成像来说并不实用。为了该提案提出了用于综合评估颅内狭窄和动脉瘤的下一代加速成像技术，该技术将通过新图像采集和约束重建方法的共生发展来媲美并超越计算机断层扫描（CT）。开发稳健的定量 MRA (qMRA) 方法，这是一种多对比高分辨率血管成像范例，为了实现伪影减少、空间分辨率和信噪比所需的组合。利用新颖的超短回波时间采集技术与基于稳健模型的重建技术相结合，通过更快速、更高效地采集数据，这些策略可以提高空间分辨率，同时减轻复杂流程中的诊断模糊伪影。旨在利用这些进展将血管造影 MRI 与高度加速 4D 流和血管壁成像相结合，以研究完整颅内血管重塑、炎症和血流动力学之间的相互作用最终目标是利用非侵入性成像观察不良血流动力学条件与动脉壁增强之间的相关性，这可能提供新的临床治疗范例并改善广泛的神经血管疾病的治疗。