Optimizing mHealth for adherence monitoring and intervention

优化移动医疗以进行依从性监测和干预

基本信息

批准号：
10251996
负责人：
Jessica Elizabeth Haberer
金额：
$ 18.15万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-01 至 2022-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10251996
关键词：
AIDS prevention Adherence Africa Anti-Retroviral Agents Award Boston Caring Consolidated Framework for Implementation Research Counseling Data Development Dose Faculty Feedback Foundations Funding General Hospitals Goals Grant Growth HIV HIV antiretroviral Health Benefit Health Technology Individual Infrastructure Ingestion Institution International Internist Intervention Lead Manuscripts Massachusetts Medicine Mentors Mentorship Methodology Mid-Career Clinical Scientist Award (K24)Monitor National Institute of Mental Health Paper Pattern Peer Review Pharmaceutical Preparations Postdoctoral Fellow Principal Investigator Process Productivity Proxy Publications Research Research Personnel Rewards Risk Role Rural Structure Talents Text Messaging Time Training Tuberculosis Uganda United States National Institutes of Health Viral Work Writing antiretroviral therapy base burden of illness career clinical care comorbidity design doctoral student experience global health implementation science implementation strategy improved interest mHealth medical schools mid-career faculty patient oriented research pill pre-doctoral programs skills therapy adherence tool uptake viral rebound viral transmission

项目摘要

Project summary Overview. This application for a K24 mid-career investigator award proposes to support mentoring for junior investigators interested in mHealth to improve adherence monitoring and intervention for HIV and related comorbid conditions. Candidate: Dr. Haberer is a practicing internist, the Director of Research at the Massachusetts General Hospital (MGH) Center for Global Health, and an Associate Professor of Medicine at Harvard Medical School (HMS). She has nearly 10 years of experience studying adherence to antiretroviral therapy for both the treatment and prevention of HIV in developing settings, with a particular focus on mHealth. Dr. Haberer is considered a leader in her field and most specifically in electronic adherence monitors and SMS-based monitoring and intervention. Dr. Haberer is also a dedicated mentor and has supported 21 pre-doctoral students, residents, post-doctoral fellows and junior faculty, both in Boston and abroad. Her mentees have written 18 first author papers (5 additional papers are in process) and received six NIH-funded grants with her guidance. As a testament to her mentoring, she won the prestigious HMS Young Mentor Award in 2014. Mentoring Plan: Dr. Haberer’s mentoring goals are to 1) increase mentoring activities in mHealth-based adherence monitoring and intervention; and 2) establish a structured mentoring program at the MGH Center for Global Health. She can access mentees through MGH, HMS, and other Harvard-affiliated institutions, as well as her research partner institutions in East Africa. Dr. Haberer is currently the principal investigator on two R01 grants through NIMH, as well as a large scale grant through the Bill and Melinda Gates Foundation. She therefore has the capacity for numerous mentees to participate in her on-going studies through analysis of existing data and supplemental projects. Dr. Haberer will also be expanding her research into implementation science, in which she will engage additional mentees. She has been receiving an increasing number of requests for mentorship that would require the support of this award. Research Plan: Dr. Haberer proposes to expand her research program into implementation science for mHealth-based adherence monitoring and intervention. This goal involves both acquiring formal training in implementation science, as well as conducting implementation science research on the use of electronic ART adherence monitoring plus support for routine clinical care in Uganda. She aims to 1) conduct multi-level formative work to design a preliminary implementation strategy; and 2) use an iterative approach to optimize the implementation strategy based on the Consolidated Framework for Research Implementation. This proposed research will help determine ways to move effective mHealth tools from the research context into routine clinical care, as well as advance Dr. Haberer’s career and serve as a platform for mentee involvement.

项目概要概述本申请申请 K24 职业生涯中期调查员奖励提案，以支持对初级人员的指导。研究人员对移动医疗感兴趣，以改善艾滋病毒及相关疾病的依从性监测和干预合并症。候选人：Haberer 博士是一名执业内科医生、马萨诸塞州总医院研究主任医院 (MGH) 全球健康中心、哈佛医学院医学副教授 (HMS)，她在研究抗逆转录病毒治疗的依从性方面拥有近 10 年的经验。 Haberer 博士致力于发展中地区艾滋病毒的治疗和预防，特别关注移动医疗。被认为是她所在领域的领导者，特别是在电子依从性监测器和基于短信的领域 Haberer 博士也是一位热忱的导师，并为 21 名博士前学生提供了支持。她的学生、住院医师、博士后研究员和初级教师，无论是在波士顿还是在国外。撰写了 18 篇第一作者论文（另外 5 篇论文正在处理中），并与她一起获得了 6 项 NIH 资助的资助作为她指导的遗产，她于 2014 年获得了著名的 HMS 青年导师奖。指导计划：Haberer 博士的指导目标是 1) 增加基于移动医疗的指导活动依从性监测和干预；2) 在 MGH 中心建立结构化指导计划她还可以通过 MGH、HMS 和其他哈佛附属机构接触学员。 Haberer 博士是她在东非的研究合作伙伴机构，目前是两项 R01 的首席研究员。通过 NIMH 提供的资助，以及通过比尔和梅琳达·盖茨基金会提供的大规模资助。因此，许多学员有能力通过分析参与她正在进行的研究 Haberer 博士还将把她的研究扩展到实施。科学，她将吸引更多的学员。需要该奖项支持的指导请求。研究计划：哈贝勒博士建议将她的研究计划的实施扩展到科学领域基于移动医疗的依从性监测和干预包括获得正规培训。实施科学，以及对电子 ART 的使用进行实施科学研究她的目标是 1) 进行多层次的依从性监测以及对乌干达常规临床护理的支持。设计初步实施策略的形成性工作；2) 使用迭代方法进行优化基于研究实施综合框架的实施策略。拟议的研究将有助于确定将有效的移动医疗工具从研究背景转移到常规临床护理，以及推进 Haberer 博士的职业生涯并作为学员参与的平台。

项目成果

期刊论文数量（8）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Mobile Phone-Based Intervention Among Adolescents Living With Perinatally Acquired HIV Transitioning from Pediatric to Adult Care: Protocol for the Interactive Transition Support for Adolescents Living With HIV using Social Media (InTSHA) Study.

对围产期感染艾滋病毒的青少年从儿科护理过渡到成人护理的基于手机的干预：使用社交媒体为艾滋病毒感染青少年提供互动过渡支持的协议 (InTSHA) 研究。

DOI：
发表时间：
2022-01-21
期刊：
影响因子：
1.7
作者：
Zanoni, Brian C;Archary, Moherndran;Sibaya, Thobekile;Goldstein, Madeleine;Bergam, Scarlett;Denton, David;Cordero, Vincente;Peng, Cynthia;Psaros, Christina;Marconi, Vincent C;Haberer, Jessica E
通讯作者：
Haberer, Jessica E

Brief Report: The Impact of Disease Stage on Early Gaps in ART in the "Treatment for All" Era-A Multisite Cohort Study.

简要报告：“全民治疗”时代疾病分期对 ART 早期差距的影响——多中心队列研究。

DOI：
发表时间：
2021-04-15
期刊：
影响因子：
0
作者：
Katz, Ingrid T;Musinguzi, Nicholas;Bell, Kathleen;Cross, Anna;Bwana, Mwebesa B;Amanyire, Gideon;Asiimwe, Stephen;Orrell, Catherine;Bangsberg, David R;Haberer, Jessica E;META (Measuring Early Treatment Adherence) Team Investigators
通讯作者：
META (Measuring Early Treatment Adherence) Team Investigators

"I am not shy anymore": A qualitative study of the role of an interactive mHealth intervention on sexual health knowledge, attitudes, and behaviors of South African adolescents with perinatal HIV.

“我不再害羞了”：一项关于交互式移动健康干预措施对感染围产期艾滋病毒的南非青少年性健康知识、态度和行为的作用的定性研究。

DOI：
发表时间：
2022-12-01
期刊：
影响因子：
3.4
作者：
Bergam, Scarlett;Sibaya, Thobekile;Ndlela, Nompumelelo;Kuzwayo, Mpume;Fomo, Messaline;Goldstein, Madeleine H;Marconi, Vincent C;Haberer, Jessica E;Archary, Moherndran;Zanoni, Brian C
通讯作者：
Zanoni, Brian C

The impact of prevention-effective PrEP use on HIV incidence: a mathematical modelling study.

预防有效的 PrEP 使用对 HIV 发病率的影响：数学模型研究。