Family Study of Risk for Alcoholism Over the Life Course

一生中酗酒风险的家庭研究

• 批准号: 8901829
• 负责人: Mary M Heitzeg
• 金额: $ 65.64万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-04-01 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8901829
• 关键词: Accidents; Adult; Age; Alcohol abuse; Alcohol consumption; Alcohol or Other Drugs use; Alcoholism; Alcohols; Antisocial Personality Disorder; Anxiety; Area; Behavior; Behavioral; Biological Neural Networks; Brain; Candidate Disease Gene; Child; Childhood; Cognitive; Collaborations; Comorbidity; Data; Data Collection; Data Set; Databases; Dependence; Development; Diagnosis; Disease; Disease remission; Drug Formulations; Drug usage; Early Intervention; Environment; Environmental Risk Factor; Evaluation; Evolution; Exposure to; Factor Analysis; Family; Family Study; Female; Funding; General Population; Generations; Genes; Genetic; Goals; Guide prevention; Health; Impaired cognition; Impulsivity; Individual; Lead; Life; Life Cycle Stages; Long-Term Effects; Longitudinal Studies; Magnetic Resonance Imaging; Measurement; Measures; Mediator of activation protein; Mental Depression; Mental disorders; Michigan; Modeling; Nature; Neurobiology; Neurocognitive; Neurophysiology - biologic function; Nursery Schools; Outcome; Parents; Pathway interactions; Phenotype; Positron-Emission Tomography; Prevention; Preventive Intervention; Procedures; Program Development; Psychosocial Assessment and Care; Psychosocial Factor; Relapse; Research Personnel; Resources; Risk; Risk Factors; Risk Marker; Schools; Social Adjustment; Social Behavior; Social Environment; Social Functioning; Social Network; Socialization; Structure; Symptoms; System; Time; Variant; Work; age effect; alcohol and other drug; alcohol use disorder; base; cognitive function; data management; data sharing; design; disorder risk; drinking; emerging adult; emerging adulthood; gene interaction; high risk; interest; intervention program; longitudinal database; male; meetings; middle age; prospective; psychologic; resilience; scaffold; social; theories

DESCRIPTION (provided by applicant): This prospective high-risk family study, the Michigan Longitudinal Study (MLS) began 27 years ago to characterize the development of risk for alcohol use disorder (AUD) among children (2nd generation or G2s) beginning prior to school entry, with the aims to detect whether risk markers of later disorder could be identified very early, to characterize the evolution of identified risk factors over the course of childhood and early adulthood, and to identify mediators and moderators of risk development that could guide prevention or early intervention programming. Aims for the parents (G1s) were to identify factors that predict relapse, remission, and social adaptation. The project is the earliest beginning (age 3) high risk for AUD study currently active, and involves one of the longest spans of prospective assessment of alcohol/other drug use. Its data matrix involves repeated measurement of a variable network of behavioral, cognitive, and psychological functioning, social environment, substance use/abuse, and psychiatric symptoms. It is also interdigitated with 5 other projects which utilize the MLS as their recruitment, data management, and conceptual core, and share all data. This renewal application proposes continued characterization of G2s as the scientifically most unique segment of the study, limiting G1 assessments to measures critical to characterizing the socialization environment of G2s. G2s have been assessed since preschool and drinking/other drug use is assessed from time of onset. Continued collection of these data will allow evaluation of the prospective effects of precursive risk, in interaction with early substance use, upon later behavior. We intend to fully characterize two critical issues in G2s: 1) Identification of the developmental risk pathways that lead to an AUD outcome without psychiatric comorbidity as contrasted with one involving a comorbid externalizing or internalizing diagnosis; (Aim 1); and 2) Identification of the factors that predict a resilient (non-alcohol abusing) outcome in emerging adulthood, despite precursive exposure to adversity (Aim 2). Furthermore, we intend to take advantage of the comprehensive multi-domain matrix of data available from the core study and its offshoot partner-projects to build cross-level, developmental models of mechanistic structure for critical risk and resilience phenotypes for problem alcohol use and AUD across levels of genes, neural networks, social environment, and development (Aim 3). In order to fully capitalize on the maturity of the study, we will also use th extensive multi-wave database to characterize a critical issue in the G1s: evaluating the long term effects of alcohol consumption burden upon cognitive function in middle to later adulthood (Aim 4). With more than a generation of real time information the project will be able to prospectively evaluate these effects over the course of 27 years. Finally, we intend to provide the now very long-term longitudinal database as a resource for the field. Thus, our final aim is to establish a project development program involving meetings adjunctive to RSA and CPDD for investigators to share data and issues, with the goal of developing a collaborative network (Aim 5).

描述（由申请人提供）：这项前瞻性高风险家庭研究，即密歇根纵向研究 (MLS)，于 27 年前开始，旨在描述儿童（第二代或 G2 代）中酒精使用障碍 (AUD) 风险的发展情况。入学，目的是检测是否可以很早就识别出后来的疾病的风险标记，描述已识别的风险因素在儿童期和成年早期的演变特征，并确定风险发展的中介因素和调节因素，这些因素可以指导预防或早期干预规划。父母（G1）的目标是确定预测复发、缓解和社会适应的因素。该项目是目前正在进行的 AUD 研究中最早开始（3 岁）的高风险项目，并且涉及对酒精/其他药物使用的前瞻性评估的最长跨度之一。其数据矩阵涉及对行为、认知和心理功能、社会环境、物质使用/滥用和精神症状的可变网络的重复测量。它还与其他 5 个项目相互结合，这些项目利用 MLS 作为招聘、数据管理和概念核心，并共享所有数据。该更新申请建议继续将 G2 表征为该研究中科学上最独特的部分，将 G1 评估限制为对表征 G2 社会化环境至关重要的措施。 G2 从学前班开始就进行评估，饮酒/其他药物使用从发病时开始评估。持续收集这些数据将有助于评估前驱风险与早期物质使用相互作用对以后行为的预期影响。我们打算充分描述 G2 中的两个关键问题：1）识别导致不伴有精神共病的 AUD 结果的发育风险路径，与涉及共病外化或内化诊断的情况形成对比； （目标 1）； 2) 确定预测成年初期的弹性（非酒精滥用）结果的因素，尽管预先暴露于逆境（目标 2）。此外，我们打算利用核心研究及其分支合作项目提供的全面的多领域数据矩阵，为问题酒精使用和 AUD 的关键风险和恢复表型建立跨层次的机械结构发展模型跨越基因、神经网络、社会环境和发展的各个层面（目标 3）。为了充分利用这项研究的成熟性，我们还将使用广泛的多波数据库来描述 G1 中的一个关键问题：评估酒精消费负担对成年中后期认知功能的长期影响（目标4).凭借一代以上的实时信息，该项目将能够前瞻性地评估 27 年来的这些影响。最后，我们打算提供现在非常长期的纵向数据库作为该领域的资源。因此，我们的最终目标是 建立一个项目开发计划，其中包括 RSA 和 CPDD 的辅助会议，以便研究人员共享数据和问题，目标是开发协作网络（目标 5）。