Early childhood nutrition and adult metabolomic and cardiometabolic profiles

幼儿营养和成人代谢组学和心脏代谢特征

• 批准号: 8630478
• 负责人: ARYEH DAVID STEIN
• 金额: $ 53.6万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-10 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8630478
• 关键词: Accounting; Acute; Address; Adult; Affect; Age; Attenuated; Biological Assay; Biological Markers; Birth; Blood capillaries; Blood specimen; Build-it; Central America; Characteristics; Child; Child Malnutrition; Childhood; Chronic; Clinical; Cohort Studies; Collaborations; Collection; Communicable Diseases; Communities; Conceptions; Country; Data; Data Analyses; Databases; Development; Diabetes Mellitus; Diagnosis; Dietary Intervention; Disease; Elements; Ensure; Epidemic; Etiology; Event; Exposure to; Failure; Future; Glucose; Growth; Guatemala; Guatemalan; Health; High Prevalence; Human; Income; Infection; Inflammation; Institutes; Intervention; Intervention Trial; Laboratories; Life; Life Cycle Stages; Link; Lipids; Long-Term Effects; Longevity; Malignant Neoplasms; Malnutrition; Methods; Nutritional; Obesity; Panama; Paper; Perinatal; Population Study; Positioning Attribute; Prevalence; Proteins; Publishing; Randomized Controlled Trials; Recording of previous events; Research; Research Personnel; Resolution; Risk; Risk Factors; Role; Sampling; Statistical Methods; Supplementation; Surveys; Testing; Time; Universities; Update; Work; adult nutrition; burden of illness; capillary; cohort; combat; disability-adjusted life years; disorder risk; drinking; early childhood; effective intervention; experience; improved; innovation; member; metabolomics; multidisciplinary; novel; nutrition; public health relevance; research facility; response; socioeconomics

PROJECT SUMMARY / ABSTRACT Nutrition and infection are key determinants of child growth and survival. Chronic inflammation, which results in part from an increased lifetime burden of infectious disease, is an underlying determinant of adult cardiometabolic disease. The modifiability of this risk by improving nutrition in early life is unknown. Our principal objective is to determine whether improvements in early-life nutrition can attenuate the development of cardiometabolic risk. We will collect new data from the INCAP (Guatemala) Nutrition Supplementation Trial cohort. From 1969-77, 2392 children received atole, a high protein and calorie supplement, or fresco, a low calorie drink, for up to 8 y. Children who received atole in the first 3 y of life grew better in childhood and recovered more quickly from diarrheal illness episodes than did children who received fresco. We have followed this cohort prospectively. We propose to re-contact the surviving members of the cohort. The cohort will be 38-53 y old, an ideal age to assess cardiometabolic risk. We will conduct clinical examinations, including (for the first time in this cohort) collection of biomarkers of cardiometabolic risk. We will assay the samples for established and novel biomarkers, including highly innovative metabolomic profiling. We will update and enhance the extensive life-course data that we collected in previous surveys. We will link the new data to our existing rich database to address critical questions regarding the long-term effects on cardiometabolic health of both chronic under-nutrition and an effective intervention to combat under-nutrition, in the context of a community-randomized trial that controls for otherwise intractable questions of endogeneity. The study will be unique in its ability to address unanswered questions relating to early life determinants of adult health. This prospectively-studied cohort has reached an age where the prevalence of cardiometabolic risk is non-negligible. The highly productive research team has extensive experience with survey work among this cohort, demonstrated capacity to link data across study waves, and extensive experience with the appropriate field methods, laboratory methods, and statistical approaches to data analysis. The resulting extensive repository of data and samples will enhance the value of the cohort for future research. Taken together, these elements ensure that the study will be well positioned to successfully address critical understudied questions in human health and development.

项目概要/摘要 营养和感染是儿童生长和生存的关键决定因素。慢性炎症， 其部分原因是终生传染病负担增加，是一个潜在的 成人心脏代谢疾病的决定因素。通过改善营养来改变这种风险 早年生活未知。 我们的主要目标是确定生命早期营养的改善是否可以减弱 心脏代谢风险的发展。我们将从 INCAP（危地马拉）收集新数据 营养补充试验队列。从 1969 年至 77 年间，2392 名儿童接受了 atole，这是一种高 蛋白质和热量补充剂，或低热量饮料 fresco，可持续使用长达 8 岁。儿童谁 在生命的前 3 年接受 atole 在童年时期生长得更好并且恢复得更快 与接受 fresco 的儿童相比，腹泻疾病发作率更高。我们关注了这个群体 前瞻性地。我们建议重新联系该队列中的幸存成员。该队列将是 38-53岁，是评估心脏代谢风险的理想年龄。我们将进行临床检查， 包括（在该队列中首次）收集心脏代谢风险的生物标志物。我们将 检测样品中已建立的和新颖的生物标志物，包括高度创新的生物标志物 代谢组学分析。我们将更新和增强我们所掌握的广泛的生命历程数据 之前的调查中收集到的。我们将把新数据链接到我们现有的丰富数据库来解决 关于慢性和慢性疾病对心脏代谢健康的长期影响的关键问题 营养不良问题和有效干预措施以解决营养不良问题 社区随机试验，控制其他棘手的内生性问题。 该研究的独特之处在于它能够解决与早期生活有关的未解答的问题 成人健康的决定因素。这个前瞻性研究的队列已经达到了这样的年龄 心脏代谢风险的普遍存在是不可忽视的。高产的研究团队拥有 在该群体的调查工作中拥有丰富的经验，表现出链接数据的能力 跨研究波，以及在适当的现场方法、实验室方面的丰富经验 方法和数据分析的统计方法。由此产生的广泛的数据存储库 样本将提高该队列对未来研究的价值。综合起来，这些 这些要素确保该研究能够成功解决关键问题 人类健康和发展方面的问题尚未得到充分研究。