Study the chromatin binding proteins in embryonic stem cells

研究胚胎干细胞中的染色质结合蛋白

• 批准号: 8157734
• 负责人: Jing Huang
• 金额: $ 39.77万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8157734
• 关键词: Binding Proteins; Chromatin; embryonic stem cell

Stem cell therapy have great potentials in clinical application. ES cells represent an unlimited source to generate all different types of adult stem cells. However, the events during the differentiation of ES cells into adult stem cells are unclear, although it is thought that epigenetic events are critical for this process. We plan to study the chromatin binding proteins in ES cells. Chromatin binding proteins are proteins which are critical for regulating the epigenetic events. Therefore, this project will provide molecular insights into the differentiation process of ES cells and faciliate the clinical utilization of ES cells.

干细胞疗法在临床应用中具有巨大的潜力。 ES细胞代表了生成所有不同类型的成年干细胞的无限来源。然而，尽管表观遗传事件对于此过程至关重要，但ES细胞分化为成年干细胞的事件尚不清楚。我们计划研究ES细胞中的染色质结合蛋白。染色质结合蛋白是蛋白质，对于调节表观遗传事件至关重要。因此，该项目将为ES细胞的分化过程提供分子见解，并促进ES细胞的临床利用。