Super-resolution dual-energy dental CT based on distributed x-ray source and photon counting detector

基于分布式X射线源和光子计数探测器的超分辨率双能牙科CT

• 批准号: 10258444
• 负责人: Emre Toker
• 金额: $ 22.17万
• 依托单位: TETRAIMAGING, LLC
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-21 至 2023-09-21
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10258444
• 关键词: 3-Dimensional; Address; Advanced Development; Algorithms; Anatomy; Animals; Anodes; Benchmarking; Cadaver; Clinical; Computer-Aided Design; Computer-Assisted Manufacturing; Dental; Dental Care; Dental Clinics; Dental Education; Dental General Practice; Dentistry; Detection; Diagnosis; Diagnostic Imaging; Diagnostic radiologic examination; Effectiveness; Electronics; Evaluation Studies; Flying body movement; Freezing; Geometry; Goals; Image; Imaging Techniques; Imaging technology; Immune; Implant; Inferior; Knowledge; Lesion; Location; Modeling; Morphologic artifacts; Motion; Noise; Operative Surgical Procedures; Optics; Oral; Oral Pathology; Outcome; Outcomes Research; Patient Care; Patient-Focused Outcomes; Patients; Performance; Phase; Photons; Play; Procedures; Productivity; Quality of Care; Radiation exposure; Rehabilitation therapy; Research Personnel; Resolution; Roentgen Rays; Role; Rotation; Saints; Scanning; Small Business Technology Transfer Research; Source; Spottings; Starvation; Structure; System; Technology; Three-Dimensional Image; Three-Dimensional Imaging; Time; Tissues; Tube; Universities; X-Ray Computed Tomography; base; clinical implementation; commercial application; cone-beam computed tomography; density; design; detector; high resolution imaging; image reconstruction; imaging modality; imaging system; improved; inferior alveolar nerve; innovation; interest; novel; photon-counting detector; point of care; prototype; reconstruction; research clinical testing; soft tissue; stem

ABSTRACT With cone-beam CT's introduction in dentistry, dental clinicians could not only have profound knowledge of oral pathology but could also enhance the access to a detailed view of the underlying structures and their relations. Dental CBCT could be justified for presurgical diagnosis, preoperative planning and preoperative transfer for oral implant rehabilitation. The image quality of CBCT, however, is suboptimal and suffers from strong image artifacts stemming from excessive x-ray scattering, limited detector performance. Spatial resolution, the most important parameter objectively defining image quality, is insufficient for many dental applications where the fine details often have to be depicted. We will develop and validate a novel dental imaging system that not only fundamentally eliminates the image quality problems and but also can produce superior image resolution in 3D images. The super-resolution dual-energy Tetrahedron Beam CT (TBCT) employs a novel multi-pixel thermionic emission x-ray (MPTEX) source with wobbling focal spots as well as an energy-resolved photon-counting detector (PCD). TBCT scans the patient with a stack of fan beams that have a very low scatter-to-primary ratio (SPR); The PCD detector can count x-ray photons without electronics noises, thus can reduce radiation exposure and dental artifacts due to photon starvation; The dual-energy capacity of PCD further eliminates beam-hardening artifacts and supports material decomposition; The flying focal spots and Time-delay-integration (TDI) detection will compensate gantry motion, and super-resolution 3D images can be reconstructed with optics-model based iterative image reconstruction (IIR). Super-resolution dental TBCT will fit in the gap of high-performance 3D imaging in dentistry, allow further advancing the productivity and quality of care in dental practice. The following specific aims have been designed to accomplish this goal: Aim 1: Develop MPTEX source with variable focal spot size and location; Aim 2: To develop and validate a super-resolution dental TBCT benchtop imaging system.

抽象的 随着锥束 CT 在牙科领域的引入，牙科临床医生不仅能够获得深厚的知识 口腔病理学，但也可以增强对底层结构及其细节的了解 关系。牙科 CBCT 可用于术前诊断、术前计划和术前 转移进行口腔种植康复。然而，CBCT 的图像质量并不理想，并且受到以下问题的影响： 由于过度的 X 射线散射、有限的探测器性能而产生强烈的图像伪影。空间 分辨率是客观定义图像质量的最重要参数，但对于许多牙科来说是不够的 经常需要描绘精细细节的应用程序。我们将开发并验证一种新型牙科 成像系统不仅从根本上消除了图像质量问题，而且可以产生 3D 图像中的卓越图像分辨率。超分辨率双能四面体束CT（TBCT） 采用新型多像素热电子发射 X 射线 (MPTEX) 源，具有摆动焦点以及 能量分辨光子计数探测器（PCD）。 TBCT 使用一堆扇形光束扫描患者 具有非常低的散射与主光比 (SPR)； PCD 探测器可以对 X 射线光子进行计数，而无需 电子噪声，因此可以减少辐射暴露和由于光子匮乏而导致的牙齿伪影；这 PCD 的双能能力进一步消除了光束硬化伪影并支撑材料 分解;飞行焦点和延时积分（TDI）检测将补偿龙门架 运动和超分辨率 3D 图像可以使用基于光学模型的迭代图像进行重建 重建（IIR）。超分辨率牙科 TBCT 将填补高性能 3D 成像的空白 牙科，可以进一步提高牙科诊所的生产力和护理质量。下列 已设计了具体目标来实现此目标： 目标 1：开发具有变量的 MPTEX 源 焦点大小和位置；目标 2：开发并验证超分辨率牙科 TBCT 台式 成像系统。