Core B - Clinical

核心 B - 临床

基本信息

批准号：
8849210
负责人：
HILLEL GROSSMAN
金额：
$ 34.06万
依托单位：
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8849210
关键词：
Affect Age Alzheimer&apos s Disease Attention Biological Biological Markers Brain Clinical Clinical Data Clinical Protocols Clinical Research Clinical Trials Cognition Cognition Disorders Cognitive Comorbidity DNA Data Data Collection Data Set Dementia Development Diagnosis Diagnostic Diffuse Lewy Body Disease Disease Elderly Ensure Evaluation Familial Dementias Fostering Genetic Goals Health system Imaging technology Impaired cognition Impairment Individual Industry Institution Methods Nursing Homes Participant Patients Population Procedures Protocols documentation Recording of previous events Recruitment Activity Registries Research Research Personnel Research Subjects Resources Risk Role Sampling Scientist Services Specimen Staging Temporal Lobe Tissue Donations Tissues Training Underrepresented Minority United States National Institutes of Health brain tissue clinical material cohort cooperative study data management data sharing design follow-up genome-wide high standard imaging biomarker instrument meetings mild cognitive impairment neuroimaging neuropathology normal aging novel outreach patient population programs tool treatment response

项目摘要

Mount Sinai ADRC: Core B (Grossman) | PROJECT SUMMARY The Clinical Core provides expertise in the clinical and biological characterization of individuals with cognitive loss and dementia and the ability to identify non-impaired older individuals. This expertise is utilized to recruit and maintain a cohort of well-characterized participants to support a broad array of dementia and cognitive research conducted within the MSADRC, the Mount Sinai Health System (MSHS,) and national initiatives such as the National Alzheimer's Coordinating Center (NACC), the Genome Wide Alzheimer's Study (GWAS), Alzheimer's Disease Cooperative Studies (ADCS), and the Alzheimer's Disease Neuroimaging Initiative (ADNI). The role of the core is to develop and implement clinical procedures for the high standard characterization of elders spanning the spectrum of normal, prodromal, and various stages of affected subjects into research-ready cohorts. The Clinical Core provides subjects, tissue, and data for studies as well as clinical research expertise related to clinical manifestations of disease, disease course, treatment responses, and recruitment feasibility to help guide the design and implementation of studies within the Center and broadly within the MSHS. Within the Center, the Clinical Core provides the essentials for research: the subjects and their clinical characterization to participate in Projects 1 and 2; the clinical characterization of subjects who provide brain donations and other specimens disseminated to the Neuropathology Core and Center's projects, and local and national research. The Core innovates in the development of assessment tools; application of assessments to new populations; adaptation of new imaging technologies into the clinical `real world'; and clinical trials of novel, under-studied or repurposed compounds. The Core has a rich and successful history of outreach to groups underrepresented in dementia research and provisions to continue this are built into this application. The Core is active in training young investigators and supporting investigators from other fields who wish to study cognition in their clinical populations.

西奈山ADRC：Core B（Grossman）|项目摘要临床核心在认知个体的临床和生物学表征方面提供了专业知识损失和痴呆症以及识别未受影响的老年人的能力。该专业知识用于招募并保持一系列特征良好的参与者，以支持各种各样的痴呆和认知能力在MSADRC，Sinai Mount Health System（MSHS）和国家倡议中进行的研究作为国家阿尔茨海默氏症协调中心（NACC），基因组广泛的阿尔茨海默氏症研究（GWAS），阿尔茨海默氏病合作研究（ADC）和阿尔茨海默氏病神经影像学倡议（ADNI）。核心的作用是开发和实施高标准的临床程序跨越正常，前驱和各个阶段的长者的表征进入研究就绪的队列。临床核心提供研究的受试者，组织和数据以及临床研究专业知识与疾病，疾病病程，治疗反应的临床表现有关，以及招聘可行性，可帮助指导中心内的研究设计和实施在MSH中。在中心内，临床核心为研究提供了必需因素：受试者和他们参加项目1和2的临床表征；受试者的临床表征提供大脑捐赠和其他将神经病理学核心和中心项目传播的标本，以及本地和国家研究。核心在开发评估工具方面创新；应用对新人群的评估；将新成像技术适应临床“现实世界”；和新型，研究不足或重新利用化合物的临床试验。核心具有丰富而成功的历史与痴呆症研究中所占不足的团体的宣传和继续此项的规定是内置的应用。该核心积极培训年轻的调查人员和支持其他领域的研究人员希望在临床人群中学习认知。