Development and Validation of a Collaborative Web/Cloud-Based Dosimetry System for Radiopharmaceutical Therapy.

用于放射性药物治疗的协作网络/基于云的剂量测定系统的开发和验证。

• 批准号: 10249268
• 负责人: ERIC C. FREY
• 金额: $ 70.6万
• 依托单位: RADIOPHARMACEUTICAL IMAGING AND DOSIMETRY, LLC
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10249268
• 关键词: 3-Dimensional; Architecture; Area; Big Data; Biological; Businesses; Capital; Client; Clinic; Clinical; Clinical Trials; Cloud Computing; Code; Collaborations; Complement; Computer software; Computers; Custom; Data; Data Collection; Development; Dose; Dose-Rate; Environment; External Beam Radiation Therapy; Generations; Goals; Grant; Growth; Health; Individual; Infrastructure; Internet; Investments; Licensing; Methods; Modality; Modeling; Multi-Institutional Clinical Trial; Online Systems; Pathway interactions; Patients; Pharmacologic Substance; Phase; Privacy; Process; Production; Radiation; Radioisotopes; Radiopharmaceuticals; Research Personnel; Running; Services; Side; Site; Small Business Innovation Research Grant; Software Tools; System; Systemic disease; Translating; Treatment Protocols; Uncertainty; Validation; Vendor; Work; analysis pipeline; base; cancer cell; cancer therapy; clinical application; clinical research site; cloud based; collaborative approach; computing resources; cost effective; data de-identification; data sharing; deep learning; design; dosimetry; encryption; experience; image reconstruction; image registration; imaging Segmentation; interest; medical specialties; multicore processor; neoplastic cell; precision medicine; prototype; quantitative imaging; radiation delivery; reconstruction; scale up; single photon emission computed tomography; software systems; targeted delivery; therapeutic evaluation; tool; treatment planning; treatment strategy; tumor; web services

Project Summary Radiopharmaceutical therapy (RPT) – the use of targeted radionuclides to deliver radiation specifically to cancer cells and their microenvironment – is a fundamentally different approach to cancer therapy that is growing, with a substantial number of large and small pharmaceuticals companies developing products in this area and radionuclide producers making substantial investments in scaling up production. This is especially true in the area of alpha emitters. The dosimetric evaluation of therapeutic radiopharmaceuticals is a key requirement for regulatory approval and optimal administration of RPTs, especially in combination with external beam radiation therapy. This project will provide a cloud-based dosimetry software service, delivered through a web-browser, that includes the full complement of methods needed for dosimetry in the context of obtaining regulatory approval of RPTs and, ultimately, for optimal clinical delivery. Providing this in a cloud-based system will enable a variety of models for selling the service that do not require a large up-front capital investment for clinics or radiopharmaceutical developers. It also will provide access to expert advice, customization, and dosimetry services, and allow for collaboration between developers, dosimetry experts, and clinical sites. To accomplish the goal of developing this cloud-based web-browser-delivered RPT dosimetry software service, we propose the following specific aims: (1) Design, develop and implement a web/cloud-based integrated software system for treatment planning of RPT therapy; (2) design and implement a full server-side framework for subscription, authentication, and granting collaborative privileges for the various processes and data in the dosimetry pipeline; (3) optimize and adapt the four most computationally intensive processes for a multi-processor cloud-based compute environment; (4) apply and evaluate the toolchain developed in aims 1-3 to phantom, simulated and existing patient data. Successful completion of this project will produce a cloud-based software system delivered to the user via a web browser that provides an integrated, streamlined, robust, state-of-the-art system for RPT treatment planning. This system would enable a collaborative approach to multi-center clinical trials and eventually to clinical delivery of optimally dosed RPT.

项目概要 放射性药物治疗 (RPT) – 使用靶向放射性核素专门向患者提供辐射 癌细胞及其微环境——是一种根本不同的癌症治疗方法，正在不断发展， 大量大大小小的制药公司在该领域开发产品， 放射性核素生产商在扩大生产方面进行了大量投资。 α发射体的剂量测定是治疗放射性药物的关键要求。 RPT 的监管批准和最佳管理，特别是与外部束辐射相结合 该项目将提供基于云的剂量测定软件服务，通过网络浏览器提供， 其中包括在获得监管部门批准的情况下进行剂量测定所需的全套方法 RPT 的数量以及最终的最佳临床交付效果将在基于云的系统中实现。 不需要诊所或诊所进行大量前期资本投资的服务销售模式 它还将为放射性药物开发商提供专家建议、定制和剂量测定。 服务，并允许开发人员、剂量测定专家和临床站点之间进行协作。 为了开发这种基于云的网络浏览器提供的 RPT 剂量测定软件服务的目标，我们提出 具体目标如下： (1) 设计、开发和实现基于网络/云的集成软件系统 RPT疗法的治疗计划；（2）设计和实现完整的服务器端订阅框架， 身份验证，并授予剂量测定管道中各种流程和数据的协作权限； (3) 优化和适应基于云的多处理器的四个计算最密集的进程 (4) 将目标 1-3 中开发的工具链应用于幻影、模拟和评估 该项目的成功完成将产生一个基于云的软件系统。 通过网络浏览器向用户提供集成、简化、强大、最先进的 RPT 系统 该系统将使多中心临床试验和治疗计划成为可能。 最终实现最佳剂量 RPT 的临床交付。