Mechanisms of diaphragm muscle dysfunction in critical-illness myopathy

危重症肌病膈肌功能障碍的机制

• 批准号: 8195627
• 负责人: Catherine S Sassoon
• 金额: --
• 依托单位: VETERANS HEALTH ADMINISTRATION
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8195627
• 关键词: 1-Phosphatidylinositol 3-Kinase; 70-kDa Ribosomal Protein S6 Kinases; Acute; Acute respiratory failure; Adrenal Cortex Hormones; Adult Respiratory Distress Syndrome; Adverse effects; Affect; Animal Model; Animals; Binding; Biochemical; Boxing; Caring; Cell Nucleus; Cells; Chronic Obstructive Airway Disease; Congestive Heart Failure; Continuous Positive Airway Pressure; Critical Illness; Critical Illness Polyneuropathy; Development; Dexamethasone; Diagnosis; Disease; Dose; F Box Domain; Functional disorder; Generations; Genetic Transcription; Glycogen Synthase Kinases; Health; Hospitals; Human; Impairment; Inflammatory; Inpatients; Insulin-Like Growth Factor I; Intensive Care Units; Intervention; Laboratories; Length of Stay; Light; Malnutrition; Measurement; Measures; Mechanical ventilation; Mechanics; Mediating; Membrane; Messenger RNA; Methylprednisolone; Methylprednisolone Sodium Succinate; Molecular; Muscle; Muscle Fibers; Muscle Weakness; Muscle function; Muscular Atrophy; Myopathy; Neural Conduction; Neuromuscular Diseases; Neuromuscular Junction; New Zealand; Observational Study; Oryctolagus cuniculus; Outpatients; Paralysed; Pathway interactions; Patients; Pharmaceutical Preparations; Phosphorylation; Pneumonia; Population; Postoperative Period; Prevention; Process; Production; Property; Prospective Studies; Protein Biosynthesis; Protein Dephosphorylation; Protein-Serine-Threonine Kinases; Proteins; Proteolysis; Randomized; Rattus; Recombinant IGF-I; Recovery of Function; Rehabilitation therapy; Reporting; Research; Respiratory Diaphragm; Ribosomal Protein S6; Ring Finger Domain; Risk Factors; Role; Sensory; Sepsis; Signal Pathway; Sirolimus; Skeletal Muscle; Subgroup; Survivors; System; Testing; Time; Translations; Treatment Cost; Ubiquitin; Ventilator; Veterans; Weaning; clinically relevant; cytokine; density; drug development; experience; human FRAP1 protein; improved; in vivo; interest; kinase inhibitor; mTOR Inhibitor; mTOR protein; multicatalytic endopeptidase complex; muscular structure; neuromuscular; pathogen; prevent; protein degradation; public health relevance; ubiquitin-protein ligase; wortmannin; 1-Phosphatidylinositol 3-Kinase; 70-kDa Ribosomal Protein S6 Kinases; Acute; Acute respiratory failure; Adrenal Cortex Hormones; Adult Respiratory Distress Syndrome; Adverse effects; Affect; Animal Model; Animals; Binding; Biochemical; Boxing; Caring; Cell Nucleus; Cells; Chronic Obstructive Airway Disease; Congestive Heart Failure; Continuous Positive Airway Pressure; Critical Illness; Critical Illness Polyneuropathy; Development; Dexamethasone; Diagnosis; Disease; Dose; F Box Domain; Functional disorder; Generations; Genetic Transcription; Glycogen Synthase Kinases; Health; Hospitals; Human; Impairment; Inflammatory; Inpatients; Insulin-Like Growth Factor I; Intensive Care Units; Intervention; Laboratories; Length of Stay; Light; Malnutrition; Measurement; Measures; Mechanical ventilation; Mechanics; Mediating; Membrane; Messenger RNA; Methylprednisolone; Methylprednisolone Sodium Succinate; Molecular; Muscle; Muscle Fibers; Muscle Weakness; Muscle function; Muscular Atrophy; Myopathy; Neural Conduction; Neuromuscular Diseases; Neuromuscular Junction; New Zealand; Observational Study; Oryctolagus cuniculus; Outpatients; Paralysed; Pathway interactions; Patients; Pharmaceutical Preparations; Phosphorylation; Pneumonia; Population; Postoperative Period; Prevention; Process; Production; Property; Prospective Studies; Protein Biosynthesis; Protein Dephosphorylation; Protein-Serine-Threonine Kinases; Proteins; Proteolysis; Randomized; Rattus; Recombinant IGF-I; Recovery of Function; Rehabilitation therapy; Reporting; Research; Respiratory Diaphragm; Ribosomal Protein S6; Ring Finger Domain; Risk Factors; Role; Sensory; Sepsis; Signal Pathway; Sirolimus; Skeletal Muscle; Subgroup; Survivors; System; Testing; Time; Translations; Treatment Cost; Ubiquitin; Ventilator; Veterans; Weaning; clinically relevant; cytokine; density; drug development; experience; human FRAP1 protein; improved; in vivo; interest; kinase inhibitor; mTOR Inhibitor; mTOR protein; multicatalytic endopeptidase complex; muscular structure; neuromuscular; pathogen; prevent; protein degradation; public health relevance; ubiquitin-protein ligase; wortmannin

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