Validation of Stigma Metrics for Marginalized Men

边缘化男性耻辱指标的验证

基本信息

批准号：
10133472
负责人：
Stefan David Baral
金额：
$ 60.28万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-05-05 至 2024-08-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10133472
关键词：
AIDS prevention AIDS/HIV problem Address Affect Africa South of the Sahara African Alcohol consumption American Biological Markers Caring Categories Chlamydia Chronic stress Collaborations DNA Data Data Analyses Data Set Development Diagnostic Reagent Kits Equation Ethnic Origin Factor Analysis Future Gender Goals Gonorrhea HIV HIV Infections HIV Seropositivity HIV prevention trials network HIV risk HIV/STD Health Services Accessibility Healthcare High Prevalence Home Incidence International Internet Intervention Length Measurement Measures Mediating Mediator of activation protein Mental Depression Mental Health Methods Michigan Modeling Outcome Participant Pathway interactions Population Population Programs Prevention Public Health Schools Race Recommendation Research Personnel Research Priority Research Project Grants Risk Saliva Sex Behavior Sexual Health Sexually Transmitted Diseases Specimen Stress Structure Surveys Testing Treatment outcome United States United States National Institutes of Health Universities Urine Ursidae Family Validation Validity and Reliability Viral Load result Work World Health Organization base care systems comparative experience health disparity intersectionality men men who have sex with men prevention service recruit rectal response sex sexual role social stigma telomere therapy development transmission process treatment services uptake

项目摘要

The overarching goal of this proposed study is to leverage existing and ongoing data to examine the role of sexual behavior stigma on access to HIV healthcare as well as sexual and mental health outcomes among men who have sex with men (MSM). Worldwide MSM are a key population that bear a disproportionate burden of HIV with high prevalence and incidence yet they have low uptake and/or access to treatment and prevention. Consistent with NIH HIV/AIDS research priorities, the proposed project aims to reduce health disparities in HIV infection and treatment outcomes by addressing stigma towards MSM in the context of intersecting stigmas and potentially modifiable mediators (e.g., depression). In particular, validated measures of sexual behavior stigma are needed to effectively measure stigma-related interventions and to better understand the mechanisms of how stigma potentiates HIV risks among this key population. We propose to leverage existing data collected from over 15,000 MSM across 7 different Sub-Saharan African nations, the American Men's Internet Survey (AMIS), the UCLA mSTUDY, and the HIV Prevention Trials Network (HPTN) 078 study on Enhancing Recruitment, Linkage to Care and Treatment for HIV-Infected MSM in the US. The specific aims of the work are: Aim 1) Develop validated measures used to assess sexual behavior stigma among MSM using factor analysis and validity and reliability testing. This will result in finalized stigma metrics and recommendations for integration of MSM stigma items that can be used in future studies. Aim 2) Identify specific mediated associations between stigma and HIV-related outcomes using structural equation modeling. In addition, test for intersectionality of multiple forms of stigma (e.g., gender, HIV status, race/ethnicity) using an inter- and intra-categorical approach. The delivered outcomes will include quantified associations of sexual behavior stigma with HIV-related outcomes that can be used to inform HIV intervention planning by setting feasible targets for stigma mitigation interventions. Aim 3) Include final validated stigma metrics in an upcoming cycle of AMIS and bio-validate the stigma metrics. Bio-validation will consist of testing associations of sexual behavior stigma with testing positive for sexually transmitted infections (chlamydia and gonorrhea), and with chronic stress measured using telomere DNA length. Participants will self-collect urine, rectal, and saliva specimens using home-based STI test kits. Overall, the proposed study will result in a thorough assessment of a sexual behavior stigma scale for MSM and how it operates comparatively with other types of stigma. The validated stigma metrics will provide recommendations for future studies that seek to measure stigma and its relation to HIV among this key population.

这项拟议研究的总体目标是利用现有和正在进行的数据来检查性行为耻辱对获得艾滋病毒医疗保健以及性健康和心理健康结果的影响男男性行为者 (MSM)。全球范围内的 MSM 是承受着不成比例负担的关键人群艾滋病毒感染率和发病率很高，但他们的艾滋病毒感染率和/或获得治疗的机会较低，预防。与 NIH HIV/AIDS 研究重点一致，拟议项目旨在降低健康水平通过解决男男性接触者的耻辱问题，消除艾滋病毒感染和治疗结果的差异交叉的耻辱和潜在的可改变的中介（例如抑郁症）。特别是经过验证的措施需要了解性行为耻辱，以有效衡量与耻辱相关的干预措施，并更好地了解耻辱感如何增强这一关键人群的艾滋病毒风险的机制。我们建议利用从 7 个不同的撒哈拉以南非洲国家的 15,000 多名 MSM 收集的现有数据，美国男性互联网调查 (AMIS)、加州大学洛杉矶分校 mSTUDY 和艾滋病毒预防试验网络 (HPTN) 078 研究关于加强美国艾滋病毒感染男男性行为者的招募、护理和治疗的联系。这这项工作的具体目标是：目标 1) 制定用于评估性行为耻辱的有效措施 MSM 之间使用因子分析以及有效性和可靠性测试。这将导致最终的耻辱指标以及关于整合可用于未来研究的 MSM 耻辱项目的建议。目标 2) 识别使用结构方程模型研究耻辱与艾滋病毒相关结果之间的特定介导关联。此外，使用以下方法测试多种形式的耻辱（例如性别、艾滋病毒状况、种族/民族）的交叉性类别间和类别内的方法。交付的结果将包括性的量化关联行为耻辱与艾滋病毒相关结果可用于通过设置为艾滋病毒干预计划提供信息减轻耻辱干预措施的可行目标。目标 3) 将最终经过验证的耻辱指标纳入即将到来的 AMIS 周期和生物验证耻辱指标。生物验证将由测试协会组成性传播感染（衣原体和淋病）检测呈阳性，从而消除性行为耻辱感，以及使用端粒 DNA 长度测量的慢性压力。参与者将自行收集尿液、直肠和使用家用 STI 测试套件采集唾液样本。总体而言，拟议的研究将产生彻底的结果 MSM 性行为耻辱量表的评估及其与其他类型的比较如何运作柱头。经过验证的耻辱指标将为未来寻求衡量的研究提供建议这一重点人群中的耻辱及其与艾滋病毒的关系。

项目成果

期刊论文数量（42）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

HIV prevalence and behavioral and psychosocial factors among transgender women and cisgender men who have sex with men in 8 African countries: A cross-sectional analysis.

8 个非洲国家男男性行为的跨性别女性和顺性别男性的艾滋病毒患病率以及行为和心理社会因素：横断面分析。

DOI：
发表时间：
2017-11
期刊：
影响因子：
15.8
作者：
Poteat, Tonia;Ackerman, Benjamin;Diouf, Daouda;Ceesay, Nuha;Mothopeng, Tampose;Odette, Ky;Kouanda, Seni;Ouedraogo, Henri Gautier;Simplice, Anato;Kouame, Abo;Mnisi, Zandile;Trapence, Gift;van der Merwe, L Leigh Ann;Jumbe, Vicente;Baral
通讯作者：
Baral

Trends and Characteristics Associated With Human Papillomavirus Vaccination Uptake Among Men Who Have Sex With Men in the United States, 2014-2017.

2014-2017 年美国男男性行为者接种人乳头瘤病毒疫苗的相关趋势和特征。

DOI：
发表时间：
2019
期刊：
影响因子：
3.1
作者：
Loretan, Caitlin;Chamberlain, Allison T;Sanchez, Travis;Zlotorzynska, Maria;Jones, Jeb
通讯作者：
Jones, Jeb

Disclosure of Same-Sex Sexual Practices to Family and Healthcare Providers by Men Who Have Sex with Men and Transgender Women in Nigeria.

尼日利亚男男性行为者和跨性别女性向家庭和医疗保健提供者披露同性性行为。

DOI：
发表时间：
2021
期刊：
影响因子：
3.8
作者：
Kokogho, Afoke;Amusu, Senate;Baral, Stefan D;Charurat, Manhattan E;Adebajo, Sylvia;Makanjuola, Olumide;Tonwe, Veronica;Storme, Casey;Michael, Nelson L;Robb, Merlin L;Ake, Julie A;Nowak, Rebecca G;Crowell, Trevor A;TRUST/RV368 Study Group
通讯作者：
TRUST/RV368 Study Group

From general to specific: moving past the general population in the HIV response across sub-Saharan Africa.

从一般到具体：撒哈拉以南非洲地区的艾滋病毒应对措施超越了一般人群。