Measuring Cognitive Fatigability in Older Adults

测量老年人的认知疲劳度

基本信息

批准号：
8926342
负责人：
MINGZHOU DING
金额：
$ 17.66万
依托单位：
UNIVERSITY OF FLORIDA
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-09-15 至 2017-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8926342
关键词：
Address Age Aging Attention Brain Cardiovascular system Cerebrum Clinical Trials Cognition Cognitive Cognitive aging Communities Complex Data Elderly Electroencephalography Employee Strikes Event-Related Potentials Exertion Fatigue Foundations Funding Future Goals Health Hour Image Intervention Knowledge Linear Regressions Link Longitudinal Studies Measures Metabolic Modeling Monitor Muscle NIH Program Announcements Neuraxis Neurocognitive Neurons Outcome Participant Pattern Perception Performance Physiological Play Population Procedures Process Prospective Studies Quality of life Research Resources Role Scalp structure Task Performances Techniques Testing Therapeutic Intervention actigraphy age related base clinically significant cognitive ability cognitive function cognitive performance cognitive reserve cognitive task disability effective intervention exhaustion improved innovation insight mortality neurophysiology novel programs therapeutic target tool

项目摘要

DESCRIPTION (provided by applicant): Fatigue is associated with increased mortality in older adults and is the leading cause of activity restrictions in this population. Unfortunately, our understanding of the causes of fatigue in older adults is quite limited and we have no proven treatments. While it is known that aging has profound effects on the central nervous system (CNS) and cognitive function there have been no studies to date attempting to understand how CNS and cognitive factors contribute to fatigue complaints and activity restrictions in older adults. This is a striking gap as CNS and cognitive factors may play a central role in many processes suspected to drive fatigue in older adults and would thus be a potent target for therapeutic interventions. Fatigue is a complex construct which includes subjective perceptions (perceived fatigue) and objective changes in performance (fatigability). The research objectives of this proposal are to: 1) Determine the association between an objective measure of cognitive performance fatigability and activity levels in older adults; and 2) Identify potential neuronal mechanisms of this fatigability. The long-term goal is to determine whether interventions directed at cognition and/or CNS targets restore activity levels in older adults afflicted by fatige. The central hypothesis is that cognitive performance fatigability in older adults contributes to activity restrictions and is due to aging related neurocognitive changes. This hypothesis has been formulated on the basis of our preliminary data showing: 1) Significant correlations between cognitive fatigability and both age and fatigue complaints in older adults; and 2) Associations between physiologic markers of cognitive reserve and cognitive fatigability. The rationale for the proposed research is that better objective measures of cognitive and CNS factors are needed to advance our understanding of fatigability in older adults and to identify targets for therapeutic interventions. The hypothesis will be tested through two Specific Aims: 1) Determine the correlation between cognitive performance fatigability and activity levels in older adults; and 2) Determine the relationship between cognitive fatigability and neurophysiological markers of cognitive reserve using electroencephalography (EEG). The approach is innovative because it represents the first study to examine objective cognitive fatigability as a cause of restricted activity in older adults and is the first study to determine whether physiologic measures of cerebral reserve impact cognitive fatigability. The proposed research is significant because it is expected to advance out understanding of the mechanisms of fatigability in older adults and to contribute new tools, mechanistic insights and therapeutic targets essential for advancing this field. The knowledge and techniques developed in this R21 proposal will serve as a foundation for future R01 proposals to investigate the potential for cognitive interventions t improve activity restrictions in older adults and mechanistic studies to better understand the relationship and interaction of potential causes of restricted activity in older adults including cognitive, CNS, muscular, cardiovascular and metabolic factors.

描述（由申请人提供）：疲劳与老年人的死亡率增加有关，是该人群活动限制的主要原因。不幸的是，我们对老年人疲劳原因的理解非常有限，我们没有可靠的治疗方法。众所周知，衰老对中枢神经系统（CNS）和认知功能具有深远影响，但迄今为止尚无研究试图了解中枢神经系统和认知因素如何促进老年人的疲劳投诉和活动限制。这是一个明显的差距，因为中枢神经系统和认知因素可能在许多怀疑会在老年人中疲劳的过程中起核心作用，因此将成为治疗干预措施的有效目标。疲劳是一种复杂的构造，包括主观看法（感知疲劳）和性能的客观变化（疲劳性）。该提案的研究目标是：1）确定对认知性能疲劳的客观度量与老年人的活动水平之间的关联； 2）确定这种疲劳性的潜在神经元机制。长期目标是确定针对认知和/或中枢神经系统的干预措施是否恢复受Fatige困扰的老年人的活动水平。中心假设是，老年人的认知性能疲劳性促进了活动限制，这是由于相关的神经认知变化所致。该假设是根据我们的初步数据提出的：1）认知能力疲劳与老年人的年龄和疲劳投诉之间的显着相关性； 2）认知储备的生理标记与认知疲劳之间的关联。拟议的研究的理由是，需要更好的认知和中枢神经系统因素的客观措施来提高我们对老年人疲劳性的理解，并确定治疗干预措施的目标。该假设将通过两个特定的目的进行检验：1）确定老年人认知表现疲劳与活动水平之间的相关性； 2）确定使用脑电图（EEG）的认知储备的认知疲劳性与神经生理标记之间的关系。该方法具有创新性，因为它代表了首次研究客观认知疲劳性作为老年人活动受到限制活动的原因，并且是第一个确定脑储备生理测量是否影响认知疲劳性的研究。拟议的研究之所以重要，是因为有望提高对老年人疲劳性机制的了解，并为前进的领域提供新工具，机械见解和治疗目标。在本R21提案中开发的知识和技术将成为未来R01提案的基础，以调查认知干预措施的潜力t改善了老年人的活动限制和机械研究，以更好地了解老年人，包括老年人，CN，肌肉，心血管，心血管和代理因素在内的老年人活动中潜在活动的关系和相互作用。