Coal Ash and Neurobehavioral Symptoms in Children Aged 6-14 Years Old.

煤灰与 6-14 岁儿童的神经行为症状。

基本信息

批准号：
8908767
负责人：
Kristina Marie Zierold
金额：
$ 49.25万
依托单位：
UNIVERSITY OF LOUISVILLE
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-05-01 至 2020-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8908767
关键词：
14 year old Area Aromatic Polycyclic Hydrocarbons Arsenic Attention deficit hyperactivity disorder Autistic Disorder Behavior Disorders Behavior assessment Blood Circulation Body Burden Breathing Burn injury Cadmium Caliber Child Child Behavior Checklist Chromium Clinical Coal Communities Copper Developmental Delay Disorders Diagnosis Diagnostic and Statistical Manual of Mental Disorders Disease Dust Emotional disorder Environmental Exposure Environmental Health Exposure to Focus Groups Geographic Information Systems Hazardous Substances Hazardous Waste Health Heavy Metals Home environment Household Human Ingestion Interview Kentucky Lead Learning Life Low income Lung Manganese Maps Mercury Metals Methods Modeling Neighborhoods Parents Participant Particle Size Pathway interactions Performance Power Plants Principal Investigator Property Public Health Questionnaires Radioactive Radioactive Elements Recording of previous events Recruitment Activity Regulation Research Research Personnel Residual state Risk Sampling Site Structure Structure of nail of toe Surface Surveys Symptoms Testing Time Toxic effect United States Work aged base coal ash fly ash follow-up foot hazard improved indoor exposure junior high school landfill neurobehavioral neurobehavioral disorder neurotoxic particle pollutant public health relevance remediation systems research toxic metal

项目摘要

DESCRIPTION (provided by applicant): Coal ash is generated when power plants burn coal for energy. Coal ash is not classified as a hazardous waste, so there are no federal regulations that govern its use, storage, or disposal. Most coal ash is stored in open landfills or in ponds. There are over 800 coal ash storage sites in the U.S. and many are located near residential communities. Coal ash includes many components, but fly ash, which is comprised of small, spherical particles, is the greatest component. Composition of fly ash varies, but it frequently contains toxic metals (e.g. arsenic, cadmium, chromium, copper, lead, manganese, and mercury), polycyclic aromatic hydrocarbons (PAHs), and radioactive elements. Neurobehavioral disorders in children are associated with exposure to many of the metals that are contained in fly ash. Thus, children exposed to fly ash are potentially at risk of developing neurobehavioral disorders. Children are exposed to fly ash via inhalation and ingestion from fugitive dust emissions that come off the landfills and the ponds. This project will investigate the effect of fy ash on children who live in neighborhoods near two coal ash storage sites in Louisville, Kentucky. Some children live in homes within 150 feet of coal ash landfills and ponds. Working with neighborhoods within 10 miles of the coal ash storage sites, we will complete four specific aims: (1) Characterize indoor exposure from fly ash and heavy metals in homes of children residing near coal ash store sites compared to children living further away from coal ash storage sites, (2) Determine if the heavy metal body burden differs from children residing near coal ash storage sites compared to children living further away from storage sites, (3) Assess if increased fly ash exposure and greater heavy metal body burden is associated with poorer neurobehavioral performance and more neurobehavioral symptoms, (4) Utilize mapping, spatial analysis and modeling applications of geographic information systems (GIS) for household recruitment, analysis of distance decay effects, surface interpolation of Aims 1 and 2 results, and fate and transport modeling of fly ash. Three hundred and sixty children aged 6-14 will be recruited for this study. Neurobehavioral performance will be tested using the Behavioral Assessment Research System and neurobehavioral symptoms will be assessed by the Child Behavior Checklist (CBCL). Any child who has a CBCL t score =7 will be further assessed through a Structured Clinical Interview for the Diagnosis of DSM Disorders (SCID). Environmental sampling in the homes will be completed to determine the presence of fly ash and metals. Toenail samples will be collected from the children and analyzed for heavy metals. Questionnaires and an in-home assessment will help to characterize environmental exposure history and health history of the children. The results will provide evidence to define the environmental health impact of coal ash.

描述（由适用提供）：当发电厂燃烧煤炭以供能源燃烧时，会产生煤灰。煤灰不是归类为危险废物的，因此没有联邦法规管理其使用，存储或处置。大多数煤灰都存放在开放式垃圾填埋场或池塘中。美国有800多个煤灰存储地点，许多储存地点位于居民社区附近。煤灰包含许多组件，但是粉煤灰是小的球形颗粒，是最大的组成部分。粉煤灰的组成多样，但它经常含有有毒金属（例如砷，镉，铬，铜，铅，锰，锰和汞），多环芳烃（PAHS）和放射性元素。儿童的神经行为疾病与接触粉煤灰中包含的许多金属有关。那样，暴露于粉煤灰的儿童可能有患神经行为疾病的风险。儿童因事故而暴露于粉煤灰中，并因从垃圾填埋场和池塘中散发出的逃避灰尘排放而摄入。该项目将调查FY Ash对居住在肯塔基州路易斯维尔两个煤灰存储地点附近的社区的儿童的影响。一些孩子居住在煤灰垃圾填埋场和池塘150英尺内的房屋中。与煤灰储存地点10英里以内的社区合作，我们将完成四个具体的目的：（1）与居住在煤灰储存地点的儿童相比，居住在煤灰储存地点的儿童中的粉煤灰和重金属的室内暴露量与煤灰存储站点相比，（2）与居住在储存量相关的煤炭附近的孩子相比，居住在煤炭附近的孩子是否有更多的燃料（3），如果燃烧量相关的孩子（3），如果燃烧的燃料相关，如果是居住地，如果居住在煤炭附近，则（3）是否会增加（3）（3）（3）（3），如果居住在煤灰中，则（3）（3）（3）（3）（3）是否会增加煤炭的住所（3）（3）（3）较差的神经行为性能和更多的神经行为症状，（4）利用地理信息系统（GIS）的映射，空间分析和建模应用家庭招募，距离衰减效应的分析，目标1和AIM的表面插值1和2结果以及粉煤灰的命运和运输模型。这项研究将招募360名6-14岁的儿童。神经行为性能将使用行为评估研究系统进行测试，神经行为症状将由儿童行为清单（CBCL）评估。任何具有CBCL T分数= 7的孩子将通过结构化的临床访谈进行进一步评估，以诊断DSM疾病（SCID）。房屋中的环境采样将完成，以确定粉煤灰和金属的存在。脚趾甲样品将从儿童那里收集并分析重金属。问卷和家庭评估将有助于表征环境暴露的历史和儿童健康历史。结果将提供证据来定义煤灰的环境健康影响。