RESEARCH EDUCATION PROGRAM ON COMPUTATIONAL AND STATISTICAL TOOL DEVELOPMENT FOR ADDICTION GENETICS

成瘾遗传学计算和统计工具开发研究教育计划

• 批准号: 8915941
• 负责人: Pamela Ann Madden
• 金额: $ 44.97万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8915941
• 关键词: Advisory Committees; Alcohol or Other Drugs use; Animal Model; Area; Award; Basic Science; Bioinformatics; Biological Psychiatry; Biometry; Cells; Clinical; Clinical Research; Clinical Sciences; Collaborations; Communities; Computational Biology; Computer software; Computing Methodologies; Critiques; Data; Development; Development Plans; Disease; Documentation; Drug Addiction; Education; Educational Curriculum; Educational process of instructing; Educational workshop; Environment; Epigenetic Process; Evaluation; Faculty; Family health status; Feedback; Fellowship; Generations; Genetic; Genetic Predisposition to Disease; Genetic Research; Genomics; Goals; Human; Illicit Drugs; Individual; Institutional National Research Service Award; Investments; Life; Link; Mathematics; Medical Genetics; Mentors; Methods; Modeling; Online Systems; Other Genetics; Participant; Persons; Phase; Postdoctoral Fellow; Postdoctoral Individual National Research Service Award; Procedures; Program Development; Program Evaluation; Psychology; Public Health; Qualifying; Recording of previous events; Recruitment Activity; Research; Research Infrastructure; Research Methodology; Research Personnel; Research Training; Resources; Risk; Role; Science; Scientist; Statistical Methods; Talents; Testing; Tissues; Tobacco Dependence; Training; Training Programs; Training and Education; Translating; United States National Institutes of Health; Universities; Washington; Work; addiction; computer science; epigenomics; experience; flexibility; genetic epidemiology; genome wide association study; infrastructure development; innovation; interest; member; neuroimaging; novel therapeutic intervention; operation; outreach program; post-doctoral training; programs; public health relevance; quality assurance; responsible research conduct; success; symposium; tool; tool development

 DESCRIPTION (provided by applicant): This R25 application seeks a final 5 years to continue development of a research education program (REP) focused on training in the development of computational, and statistical tools or methods to advance human addiction genetic research. By making such tools widely available (after appropriate pretesting and QC) and training a new generation of computational/statistical scientists motivated to pursue problems in addiction genetics research, the program seeks both to maximize the payoff from existing GWAS and genetic epidemiologic studies of substance use (`addiction') disorders, and to facilitate new directions in human addiction genomics research (e.g., emphasizing epigenetic mechanisms, tissue or cell-specific effects). Consistent with the flexibility of the R25 (compared to T/F) mechanisms, the non-traditional backgrounds of postdoctoral trainees (e.g., bioinformatics, computer science, statistical genetics), and the requirement to produce and share innovative tools and methods, the REP proposes a 4-year training model with 3 existing postdocs, and 4 new postdocs to be recruited during the first two years of award. The program recruits postdoctoral trainees globally to identify candidates of exceptional talent and energy, and pairs them with an exceptional, diverse and highly collaborative faculty, reflected in the significant an highly innovative contributions of current and former trainees (e.g., 0.5 million hits per month fo one web-based tool). The program takes advantage of an exceptional institutional environment, Washington University being a leader in genomics research (including epigenomics), in statistical genetics and genomics, and in biological psychiatry research (including psychiatric - and especially addiction - genetics research). It uses a research apprenticeship training model, in which a trainee is paired with a primary mentor with pertinent expertise in computational biology/statistical genomics or genetics research who has identified a problem that can advance human addiction genetics research; one or more co-mentors with strong backgrounds as clinical researchers focused on addiction genetics; and external consultants who can supplement the expertise of the mentoring team (e.g., animal models). Formal coursework at Washington University and workshops attended elsewhere in addiction research, in responsible conduct of research, and other didactics tailored to strengthen academic background (e.g., genomics, computer science) are used to advance the research education of individual postdoctoral trainees. The program is led by directors with backgrounds in addiction genetics, statistical genetics/genomics and computational biology with histories of successful collaboration. The implementation and refinement of the REP is guided by a strong Internal Program Advisory Committee with annual feedback and critique from an outstanding External Advisory Board, and from consultant participants in biennial postdoctoral symposia. We promote ongoing collaboration of addiction, statistical genetics and computational biology scientists in research and in research education beyond the life of the R25.

 描述（由应用程序提供）：该R25应用程序寻求最后5年的时间继续开发研究教育计划（REP），重点是开发计算的培训，以及统计工具或方法，以推动人类成瘾遗传研究。通过使此类工具广泛使用（经过适当的预测和QC），并培训新一代的计算/统计科学家在成瘾遗传学研究中购买问题的动机，该计划既寻求从现有GWAS中获得的回报，并从现有的GWAS和遗传性流行病学研究中最大程度地利用（成瘾）疾病的遗传学研究，并在人类的遗传学中促进了新的epection Genermist（E. Genormitige E. Genormistiqual Genormist（E. Genormention Genery）（强调人类的遗传学）（强调人类的遗传学，强调了人类的遗传学，强调了（人类的遗传学）。组织或细胞特异性作用）。 Consistent with the flexibility of the R25 (compared to T/F) mechanisms, the non-traditional backgrounds of postdoctoral trainees (e.g., bioinformatics, computer science, statistical genetics), and the requirement to produce and share innovative tools and methods, the REP proposals a 4-year training model with 3 existing postdocs, and 4 new postdocs to be recruited during the first two years of award.该计划在全球范围内报告博士后学员，以确定卓越的人才和精力的候选人，并将他们与杰出，多样化和高度协作的教职员工搭配，反映在当前和以前的受训者的高度创新贡献中（例如，每月50万个月份的命中率为50万个网络工具）。该计划利用了一个卓越的机构环境，华盛顿大学是基因组学研究（包括表观基因组学），统计遗传学和基因组学以及生物精神病学研究（包括精神病 - 尤其是成瘾 - 遗传学研究）的领导者。它使用了研究学徒培训模型，其中学员与主要的心理学配对，并在计算生物学/统计基因组学或遗传学研究方面具有相关的专业知识，后者确定了一个可以推进人类成瘾遗传学研究的问题；作为临床研究人员专注于成瘾遗传学的一个或多个具有较强背景的联合官。以及可以补充心理团队（例如动物模型）的专业知识的外部顾问。华盛顿大学的正式课程和研讨会在成瘾研究，负责任的研究以及针对强大学术背景（例如，基因组学，计算机科学）量身定制的其他教学术的其他地方都用于推进对单个博士后学员的研究教育。该计划由具有成瘾遗传学，统计遗传学/基因组学和计算生物学的董事领导，并具有成功的合作历史。代表的实施和完善是由强大的内部计划咨询委员会指导的，年度反馈和杰出的外部顾问委员会以及两年期博士后研讨会的顾问参与者的批判性。我们促进了成瘾，统计遗传学和计算生物学科学家在研究和研究教育中的持续合作。