RESEARCH EDUCATION PROGRAM ON COMPUTATIONAL AND STATISTICAL TOOL DEVELOPMENT FOR ADDICTION GENETICS

成瘾遗传学计算和统计工具开发研究教育计划

基本信息

批准号：
8915941
负责人：
Pamela Ann Madden
金额：
$ 44.97万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-01 至 2020-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8915941
关键词：
Advisory Committees Alcohol or Other Drugs use Animal Model Area Award Basic Science Bioinformatics Biological Psychiatry Biometry Cells Clinical Clinical Research Clinical Sciences Collaborations Communities Computational Biology Computer software Computing Methodologies Critiques Data Development Development Plans Disease Documentation Drug Addiction Education Educational Curriculum Educational process of instructing Educational workshop Environment Epigenetic Process Evaluation Faculty Family health status Feedback Fellowship Generations Genetic Genetic Predisposition to Disease Genetic Research Genomics Goals Human Illicit Drugs Individual Institutional National Research Service Award Investments Life Link Mathematics Medical Genetics Mentors Methods Modeling Online Systems Other Genetics Participant Persons Phase Postdoctoral Fellow Postdoctoral Individual National Research Service Award Procedures Program Development Program Evaluation Psychology Public Health Qualifying Recording of previous events Recruitment Activity Research Research Infrastructure Research Methodology Research Personnel Research Training Resources Risk Role Science Scientist Statistical Methods Talents Testing Tissues Tobacco Dependence Training Training Programs Training and Education Translating United States National Institutes of Health Universities Washington Work addiction computer science epigenomics experience flexibility genetic epidemiology genome wide association study infrastructure development innovation interest member neuroimaging novel therapeutic intervention operation outreach program post-doctoral training programs public health relevance quality assurance responsible research conduct success symposium tool tool development

项目摘要

DESCRIPTION (provided by applicant): This R25 application seeks a final 5 years to continue development of a research education program (REP) focused on training in the development of computational, and statistical tools or methods to advance human addiction genetic research. By making such tools widely available (after appropriate pretesting and QC) and training a new generation of computational/statistical scientists motivated to pursue problems in addiction genetics research, the program seeks both to maximize the payoff from existing GWAS and genetic epidemiologic studies of substance use (`addiction') disorders, and to facilitate new directions in human addiction genomics research (e.g., emphasizing epigenetic mechanisms, tissue or cell-specific effects). Consistent with the flexibility of the R25 (compared to T/F) mechanisms, the non-traditional backgrounds of postdoctoral trainees (e.g., bioinformatics, computer science, statistical genetics), and the requirement to produce and share innovative tools and methods, the REP proposes a 4-year training model with 3 existing postdocs, and 4 new postdocs to be recruited during the first two years of award. The program recruits postdoctoral trainees globally to identify candidates of exceptional talent and energy, and pairs them with an exceptional, diverse and highly collaborative faculty, reflected in the significant an highly innovative contributions of current and former trainees (e.g., 0.5 million hits per month fo one web-based tool). The program takes advantage of an exceptional institutional environment, Washington University being a leader in genomics research (including epigenomics), in statistical genetics and genomics, and in biological psychiatry research (including psychiatric - and especially addiction - genetics research). It uses a research apprenticeship training model, in which a trainee is paired with a primary mentor with pertinent expertise in computational biology/statistical genomics or genetics research who has identified a problem that can advance human addiction genetics research; one or more co-mentors with strong backgrounds as clinical researchers focused on addiction genetics; and external consultants who can supplement the expertise of the mentoring team (e.g., animal models). Formal coursework at Washington University and workshops attended elsewhere in addiction research, in responsible conduct of research, and other didactics tailored to strengthen academic background (e.g., genomics, computer science) are used to advance the research education of individual postdoctoral trainees. The program is led by directors with backgrounds in addiction genetics, statistical genetics/genomics and computational biology with histories of successful collaboration. The implementation and refinement of the REP is guided by a strong Internal Program Advisory Committee with annual feedback and critique from an outstanding External Advisory Board, and from consultant participants in biennial postdoctoral symposia. We promote ongoing collaboration of addiction, statistical genetics and computational biology scientists in research and in research education beyond the life of the R25.

描述（由申请人提供）：此 R25 申请寻求最后 5 年继续开发研究教育计划 (REP)，重点是开发计算和统计工具或方法的培训，以推进人类成瘾基因研究。广泛使用的工具（经过适当的预测试和质量控制后）并培训新一代计算/统计科学家，他们有动力解决成瘾遗传学研究中的问题，该计划力求最大限度地提高现有 GWAS 和物质使用的遗传流行病学研究的回报（“成瘾”）疾病，并促进人类成瘾基因组学研究的新方向（例如，强调表观遗传机制、组织或细胞特异性效应），与 R25（与 T/F 相比）机制的灵活性一致。 -针对博士后培训生的传统背景（例如生物信息学、计算机科学、统计遗传学），以及生产和分享创新工具和方法的要求，REP提出了为期 4 年的培训计划该项目在全球范围内招募博士后实习生，以识别具有杰出才能和精力的候选人，并将他们与杰出、多元化和高度协作的教师队伍相结合。这反映在现任和前任学员的重大高度创新贡献上（例如，一个基于网络的工具每月有 50 万次点击），该计划利用了华盛顿大学在基因组学研究领域处于领先地位的特殊制度环境。它使用研究学徒培训模式，其中学员与具有计算生物学相关专业知识的主要导师配对。 /统计基因组学或遗传学研究，已发现可以推进人类成瘾遗传学研究的问题；一名或多名具有深厚背景的共同导师，专注于成瘾遗传学的临床研究人员；以及可以补充指导专业知识的外部顾问；华盛顿大学的正式课程和在其他地方参加的成瘾研究、负责任的研究以及其他旨在加强学术背景（例如基因组学、计算机科学）的讲习班被用来推进研究教育。该项目由具有成瘾遗传学、统计遗传学/基因组学和计算生物学背景的主任领导，并且具有成功合作的历史。REP 的实施和完善由一个强大的内部项目咨询委员会负责指导，每年进行一次。来自杰出外部顾问委员会以及两年一次的博士后研讨会顾问参与者的反馈和批评，我们促进成瘾、统计遗传学和计算生物学科学家在 R25 生命周期之外的研究和研究教育方面的持续合作。