Project 4

项目4

• 批准号: 8290359
• 负责人: DAVID MCCLAY
• 金额: $ 43.68万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8290359
• 关键词: Address; Arabidopsis; Biological; Biology; Cell Cycle; Cell Cycle Regulation; Cells; Cellular Structures; Characteristics; Collaborations; Complex; Development; Educational process of instructing; Embryonic Development; Exposure to; Faculty; Fellowship Program; Fostering; Graduate Education; Imagery; Life; Mammalian Cell; Mathematics; Measures; Methods; Modeling; Molecular; Nonlinear Dynamics; Organism; Physics; Plant Roots; Population; Process; Property; Regulator Genes; Relative (related person); Research; Research Personnel; Research Support; Scientist; Sea Urchins; Structure; Students; System; Systems Biology; Techniques; Variant; Yeast Model System; Yeasts; computer science; design; genetic manipulation; human disease; interdisciplinary approach; programs; statistics; symposium; theories; tool

The Duke Center for Systems Biology (DCSB) will support research collaborations aimed at discovering, modeling, and explaining the dynamical properties of biological networks. Using high throughput techniques, biologists can now determine nearly complete lists of many of the molecular components of cells, measure relative concentrations of these components, and determine which components interact with each other. A major challenge, however, is to understand how this complex network of interactions produces the orchestrated processes characteristic of living cells and higher organisms. DCSB will approach this challenge through interdisciplinary projects involving a wide array of experimental techniques, analysis tools, and modeling methods. Each project will be a collaboration between biologists and theorists with expertise in a relevant subfield of mathematics, computer science, statistics, or physics. DCSB projects will address three broad themes: (1) cell cycle control; (2) development and differentiation; and (3) population variation. In the first two, the emphasis will be on the dynamics determined by gene regulatory networks; in the third, on evolutionary dynamics of network structure. Six initial projects have been identified for support, covering networks involved in various model systems: the yeast cell cycle, mammalian cell cycle entry, Arabidopsis root development, sea urchin embryonic development, population variation in yeast, and population variation in sea urchin. Analysis and modeling efforts will draw from expertise in Bayesian statistics, nonlinear dynamics, computational topology and geometry, and visualization. DCSB will bring together outstanding researchers as collaborators and guest scientists through sabbatical and fellowship programs and through an annual symposium on a current systems biology theme. DCSB faculty will integrate systems biology themes into several existing graduate education programs that foster vertically integrated research teams and exposure to interdisciplinary approaches to biological problems. Faculty associated with DCSB will also teach several new undergraduate systems biology courses and administer a certificate program designed both for biology students and those students in mathematical/computational majors. The results will have substantial implications for treatment of human disease through manipulation of genetic regulatory systems, as well as for fundamental biology and theories of complex systems.

杜克系统生物学中心（DCSB）将支持旨在发现，建模和解释生物网络的动力学特性的研究合作。使用高吞吐量技术，生物学家现在可以确定细胞的许多分子成分的几乎完整列表，测量这些成分的相对浓度，并确定哪些组分相互相互作用。然而，一个主要的挑战是了解这种复杂的相互作用网络如何产生活细胞和更高生物的精心策划过程。 DCSB将通过跨学科项目应对这一挑战，涉及各种实验技术，分析工具和建模方法。每个项目都将是生物学家和理论家之间在相关数学，计算机科学，统计或物理学子领域具有专业知识的理论家之间的合作。 DCSB项目将解决三个广泛的主题：（1）细胞周期控制； （2）发展和分化； （3）种群变化。在前两个中，重点将放在基因调节网络确定的动态上。在第三章中，关于网络结构的进化动力学。已经确定了六个初始项目以进行支持，涵盖了各种模型系统中涉及的网络：酵母细胞周期，哺乳动物细胞周期进入，拟南芥根发育，海胆胚胎发育，酵母的种群变化以及海胆中的种群变化。分析和建模工作将借鉴贝叶斯统计，非线性动力学，计算拓扑和几何形状以及可视化的专业知识。 DCSB将通过休假和奖学金计划以及通过有关当前系统生物学主题的年度研讨会来召集出色的研究人员作为合作者和客座科学家。 DCSB教师将将系统生物学主题整合到几个现有的研究生教育计划中，这些计划促进了垂直整合的研究团队并接触到生物学问题的跨学科方法。与DCSB相关的教职员工还将教授几门新的本科系统生物学课程，并管理专为生物学学生和数学/计算专业的学生设计的证书计划。该结果将通过操纵遗传调节系统以及基本生物学和复杂系统的理论来治疗人类疾病。