Lung Cancer Disparities Center: Jointly Addressing Race & Socioeconomic Status

肺癌差异中心：共同解决种族问题

• 批准号: 8068214
• 负责人: DAVID R. WILLIAMS
• 金额: $ 167.99万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2015-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8068214
• 关键词: Lung; Cancer; Disparities; Center; Jointly

DESCRIPTION (provided by applicant): The Lung Cancer Disparities Center will be an interdisciplinary center for research (including community based participatory research), core support and dissemination activities focused on understanding and altering the determinants of racial/ethnic and socioeconomic status (SES) disparities along the continuum of lung cancer. Cigarette smoking is the primary cause of lung cancer and the key marker of high-risk in both individuals and populations; without cigarette smoking, lung cancer would be rare. Thus, identifying effective strategies to prevent the initiation of smoking and facilitate cessation among smokers is critical to reducing the risk of lung cancer. We also need to better understand the contribution of the social environment to the onset, course, and outcomes of lung cancer. The five projects and cores have the following specific aims: 1) develop and test novel tobacco control interventions that address the social context that initiate and sustain smoking behavior; 2) develop and apply sophisticated concepts, measures, and methods regarding community-focused research to all of the activities of Center; 3) draw on the expertise of a multidisciplinary team of researchers to bring a social determinants perspective to the clinical factors and other individual level factors that lead to social disparities in lung cancer survival and the genetic factors that could affect the onset, course and outcomes of lung cancer; 4) refine existing conceptual and methodological approaches to understanding and describing the joint contribution of race/ethnicity and SES to lung cancer; 5) develop a strong and cutting-edge training program to train the population health investigators of the future; and 6) fund highly innovative and high-risk pilot projects to inform research and application concerned with jointly understanding race/ethnicity and SES to disparities in lung cancer and its determinants. Significantly, this work will be accomplished by a transdisciplinary team of researchers who have made seminal contributions to population health and health disparities, in an institutional environment in which there is substantial intellectual and financial support for such an interdisciplinary Center. RELEVANCE: The Center on Lung Cancer Disparities will identify how environmental conditions - related to race/ethnicity and patterns of risk produce social disparities in lung cancer outcomes by influencing multiple pathways leading to poor health. Our Center focuses on one specific condition (lung cancer) and its key behavioral determinant (cigarette smoking). Cigarette smoking is the primary cause of lung cancer and the key marker of high-risk in both individuals and populations; without cigarette smoking, lung cancer would be rare.

描述（由申请人提供）：肺癌差异中心将是一个跨学科研究中心（包括基于社区的参与性研究），核心支持和传播活动，旨在理解和改变种族/种族和社会经济状况（SES）沿肺癌连续性的种族/族裔和社会经济状况（SES）的决定因素。吸烟是肺癌的主要原因，也是个人和人群中高风险的关键标志。如果没有吸烟，肺癌将很少见。因此，确定防止吸烟并促进吸烟者停止的有效策略对于降低肺癌的风险至关重要。我们还需要更好地了解社会环境对肺癌的发作，过程和结果的贡献。五个项目和核心具有以下特定目的：1）开发和测试新型的烟草控制干预措施，以解决启动和维持吸烟行为的社会环境； 2）开发和应用有关以社区为中心的研究的复杂概念，措施和方法； 3）利用一个多学科研究人员的专业知识，将社会决定因素的观点带到临床因素和其他个人水平因素中，这些因素导致肺癌生存的社会差异以及可能影响肺癌的发作，过程和结果的遗传因素； 4）完善现有的概念和方法论方法，以理解和描述种族/种族和SES对肺癌的共同贡献； 5）制定强大而尖端的培训计划，以培训未来的人口健康调查员； 6）为高度创新和高风险的试点项目提供资金，以为共同理解种族/种族以及对肺癌及其决定因素的差异的共同了解的研究和应用提供信息。值得注意的是，这项工作将由一个跨学科的研究人员团队完成，他们在一个机构环境中为人口健康和健康差异做出了精确贡献，在该机构环境中，对这种跨学科中心有实质性的知识和财务支持。 相关性：肺癌差异中心将确定环境状况如何与种族/种族和风险模式有关，从而通过影响多种导致健康状况不佳的途径来导致肺癌结果的社会差异。我们的中心专注于一种特定状况（肺癌）及其关键行为决定因素（吸烟）。吸烟是肺癌的主要原因，也是个人和人群中高风险的关键标志。如果没有吸烟，肺癌将很少见。