Task Specific Project 2

任务特定项目 2

• 批准号: 8135618
• 负责人: SANJIV S GAMBHIR
• 金额: $ 6.71万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8135618
• 关键词: Address; Colon; Colonoscopes; Detection; Endoscopy; Figs - dietary; Image; Imaging Device; Lesion; Malignant Neoplasms; Molecular; Molecular Target; Multiparametric Analysis; Patients; Principal Investigator; Research Personnel; Staging; imaging probe; in vivo; instrumentation; molecular imaging; molecular marker; nanoparticle; nanoprobe; particle

Project 6.2. Task-specific Project 2: Multiplexed in-vivo endoscopy by Raman imaging of cancertargeting nanoparticles Principal Investigator: Sam Gambhir Investigators: James Chan, Thomas Huser, Mike Mandella, Sebastian Wachsmann-Hogiu This task-specific project will use nanoparticles (Fig. 20) and intravital Raman imaging at near-infrared wavelengths to image molecular targets in the colon. This project supports aim 1 by providing an alternative set of imaging probes and new instrumentation that may permit multiparametric analysis of Gl cancer. A significant concern for those developing molecular imaging tools is that detection of a single molecular marker may be insufficient for specific detection and staging. Raman imaging of multiple particles with distinct spectra and molecular tags may address this concern. This possibility will be addressed through the following specific aims: Aim 1: To develop a compact colonoscope for in-vivo Raman imaging in patients Aim 2: To develop and characterize multiplexed Raman nanoparticles for Gl cancers Aim 3: To image early dysplastic lesions of the colon through in-vivo imaging of Raman nanoprobes.

项目6.2。特定于任务的项目2：通过cancertargeting的拉曼成像多路复用体内内窥镜检查 纳米颗粒 首席调查员：Sam Gambhir 调查人员：詹姆斯·陈（James Chan），托马斯·霍尔（Thomas Huser），迈克 曼德拉（Mandella），塞巴斯蒂安·沃赫斯曼·霍格（Sebastian Wachsmann-Hogiu） 这个特定于任务的项目将使用纳米颗粒（图20） 和插入式拉曼成像在近红外 波长以成像结肠中的分子靶标。这 项目支持AIM 1通过提供替代性集 可能允许的成像探针和新仪器 GL癌的多参数分析。重要的 那些开发分子成像工具的人的关注是 单个分子标记的检测可能是 不足以进行特定检测和分期。拉曼 具有不同光谱的多个粒子的成像 分子标签可能会解决此问题。这种可能性 将通过以下特定目标解决： 目标1：开发一个体内的紧凑型结肠镜 患者的拉曼成像 目标2：发展和表征多路复用拉曼 GL癌的纳米颗粒 目标3：通过拉曼纳米探针的体内成像来对结肠的早期发育不良病变进行图像。