DISCOVERY

发现

• 批准号: 8121480
• 负责人: RONALD D VALE
• 金额: $ 10.92万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8121480
• 关键词: Adhesions; Biological Assay; Candidate Disease Gene; Cell Adhesion; Cell Shape; Cells; Drosophila genus; Genes; Goals; Immigration; Organism; Pattern; Play; RNA Interference; Role; base; cell motility; knowledge base; migration

The overall goal of this Initiative is to expand the current Migration Knowledgebase through the identification of cellular genes that regulate cell shape, adhesion and motility using high throughput RNA interference screens in cell- or organism-based assays. In addition, large scale expression screens will be employed in the fruit fly to identify candidate genes that display patterns of expression and intracellular localization consistent with a role in migration. Through coordinated cross-species analyses we will identify a set of genes that play a central and conserved role in cell adhesion and migration.

该计划的总体目标是扩大当前的迁移知识库 通过鉴定使用高吞吐量调节细胞形状，粘附和运动的细胞基因 基于细胞或生物体的测定中的RNA干扰筛选。此外，大规模表达式屏幕将是 在果蝇中使用，以识别显示表达模式和细胞内的候选基因 本地化与迁移中的作用一致。通过协调的跨物种分析，我们将确定一个 一组在细胞粘附和迁移中起着中心作用的基因。