Bio-behavioral Consequences of Appearance and Performance Enhancing Drug Use

外观和性能增强药物使用的生物行为后果

• 批准号: 7848976
• 负责人: THOMAS B HILDEBRANDT
• 金额: $ 17.7万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2013-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7848976
• 关键词: Adult; Age; Aggressive behavior; Aminobutyric Acids; Anabolic steroids; Appearance; Area; Argipressin; Athletic; Behavior; Behavioral; Biological; Characteristics; Clinical; Clinical Research; Data; Dependence; Development; Disease; Drug usage; Drug user; Eating; Education; Educational Background; Endocrine; Environment; Ethical Issues; Ethics; Exercise; Fatty acid glycerol esters; Functional disorder; Funding; Goals; Growth; Hormonal; Hormones; Impulsivity; Individual; K-Series Research Career Programs; Knowledge; Learning; Legal; Licensing; Link; Longitudinal Studies; Mediating; Mediator of activation protein; Medical; Metabolic; Methodology; Mission; Modeling; Moods; Muscle; Nandrolone; Neuroendocrinology; Neurosecretory Systems; Neurotransmitters; Pattern; Performance; Personality; Pharmaceutical Preparations; Policies; Preventive Intervention; Psychiatry; Psychologist; Public Health; Recording of previous events; Regulation; Research; Research Personnel; Research Project Grants; Resources; Sampling; Science; Scientist; Serotonin; Substance abuse problem; System; Testosterone; Time; Training; Translational Research; Weight; Work; adverse outcome; base; behavior change; career; clinically significant; data modeling; design; disturbance in affect; experience; falls; improved; interest; male; medical schools; patient oriented; professor; programs; response; self esteem; skills; social; theories

DESCRIPTION (provided by applicant): The proposed K23 Patient-Oriented Career Development Award is designed to provide the PI with the training necessary to study the individual variability in bio-behavioral consequences of appearance and performance enhancing drug (APED) use. Candidate: The PI is an Assistant Professor and licensed clinical Psychologist currently working at the Mount Sinai School of Medicine's (MSSM's) Eating and Weight Disorders Program. He plans to use the K23 to become an R01 funded researcher that works closely with basic and translational scientists on the clinical, ethical, and scientific challenges presented by APED use. In order to obtain these career goals, he will use the K23 to acquire knowledge, skills, and abilities necessary to the study the relationship between endocrine/neuroendocrine function and aggression/impulsivity among APED users. His specific training objectives are to (a) learn the theoretical, methodological, and clinical approaches to studying the distinction between pathological and non-pathological forms of APED use, (b) develop a working knowledge of the theory and methodology available through translational research to study hormone-behavior relationships, (c) acquire expertise in the theory and methodology linking hormone dysregulation to psychiatric illness, (d) acquire greater understanding of the medical, legal, and ethical issues associated with studying substance abuse, and (e) obtain expertise in longitudinal data modeling and statistical analysis of biological data. Environment: The Pi's proposed training plan and career goals are consistent with the MSSM Department of Psychiatry's mission statement to integrate translational and clinical research, particularly in the area of neuroendocrinology. Dr. Hildebrandt has available to him a wealth of expertise and resources available including the lab facilitates necessary to study both endocrine and neuroendocrine functioning. Research: The most reliable psychiatric consequence to APED use is increased impulsive aggression although a range of psychiatric disturbances have been observed. The supervised research project will be a longitudinal study of the degree of both hormone and psychiatric dysregulation (aggression and impulsivity) in 60 adult male APED users across time (on-cycle and off-cycle) compared to 20 age, exercise, and education matched controls. Piecewise latent growth curve modeling will be used to investigate changes on-cycle and off-cycle changes and the following predictors of change will be explored: APED characteristics (amount, duration, and pattern), Age, Psychiatric History, Personality, & History of APED use). Relevance: Findings from the proposed study will help identify both the endocrine dysfunction responsible for the psychiatric consequences to APED use and the user characteristics predictive of these psychiatric consequences. Implications of this research are to inform prevention, intervention, and policy based decisions related to this growing public health concern.

描述（由申请人提供）：拟议的K23以患者为导向的职业发展奖旨在为PI提供必要的培训，以研究外观和性能增强药物（APED）使用的生物行为后果的个人变异性。候选人：PI是目前在西奈山医学学院（MSSM's）饮食和体重疾病计划工作的助理教授兼许可的临床心理学家。他计划使用K23成为R01资助的研究人员，与APED使用提出的临床，道德和科学挑战紧密合作。为了获得这些职业目标，他将使用K23来获得研究内分泌/神经内分泌功能与APED用户之间内分泌/侵略/冲动之间关系的知识，技能和能力。 His specific training objectives are to (a) learn the theoretical, methodological, and clinical approaches to studying the distinction between pathological and non-pathological forms of APED use, (b) develop a working knowledge of the theory and methodology available through translational research to study hormone-behavior relationships, (c) acquire expertise in the theory and methodology linking hormone dysregulation to psychiatric illness, (d) acquire greater understanding of the medical, legal, and与研究药物滥用相关的道德问题，以及（e）在纵向数据建模和生物学数据统计分析方面获得专业知识。环境：PI提出的培训计划和职业目标与MSSM精神病学系的任务声明一致，以整合翻译和临床研究，尤其是在神经内分泌学领域。希尔德布兰德博士为他提供了丰富的专业知识和资源，包括实验室促进研究内分泌和神经内分泌功能所需的必要条件。研究：尽管已经观察到了一系列的精神障碍，但对APED使用的最可靠的精神病结果是增加了冲动攻击。监督研究项目将是对激素和精神病失调（侵略性和冲动性）程度的纵向研究，与20岁，锻炼和教育匹配的控制相比，60个成年男性APED使用者（跨周期和周期）的程度。分段潜在的生长曲线建模将用于研究周期和周期变化的变化，将探讨以下变化的预测指标：APED特征（数量，持续时间和模式），年龄，年龄，精神病病史，人格和APED使用历史）。相关性：拟议的研究的发现将有助于确定导致对APED使用的精神疾病后果的内分泌功能障碍，以及预测这些精神病后果的用户特征。这项研究的含义是为与这一不断增长的公共卫生关注有关的预防，干预和基于政策的决策提供信息。