PREDICTION OF CHEMOTHERAPY INDUCED CARDIOMYOPATHY WITH MRI DETECT I

用 MRI Detect I 预测化疗引起的心肌病

• 批准号: 8167008
• 负责人: William Gregory Hundley
• 金额: $ 5.88万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-01 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167008
• 关键词: Adult; Cancer Patient; Cardiac; Cardiomyopathies; Cardiotoxicity; Cardiovascular system; Child; Computer Retrieval of Information on Scientific Projects Database; Congestive Heart Failure; Cyclophosphamide; Data; Deterioration; Doxorubicin; Funding; Grant; Institution; Left; Left Ventricular Ejection Fraction; Magnetic Resonance Imaging; Malignant Neoplasms; Measures; Myocardial perfusion; Paclitaxel; Patients; Relaxation; Research; Research Personnel; Resources; Roche brand of trastuzumab; Source; Treatment-Related Cancer; Tumor Burden; United States National Institutes of Health; Ventricular; chemotherapy; falls

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Doxorubicin prolongs survival and reduces tumor burden for many children and adults with cancer, but its use can cause irreversible congestive heart failure (CHF). Herceptin, Paclitaxel and Cyclophosphamide are also agents that are widely used for treatment of cancer and are associated with cardiotoxicity. Although a fall in left ventricular ejection (LVEF) detected during the course of chemotherapy may forecast the onset of CHF, it may occur only after irreversible cardiac damage has been sustained. Recently, cardiovascular magnetic resonance imaging (MRI) has been used to quantify regional changes in left ventricular diastolic regional relaxation. Studies in children have documented alterations in LV diastolic function in patients receiving Doxorubicin therapy often precede a deterioration in left ventricular ejection fraction. Pilot data generated from our institution indicates that MRI can be used to detect abnormalities of left ventricular relaxation in patients with varying degrees of LVEF. It is our intent to identify the association between cardiotoxicity and reductions in left ventricular diastolic relaxation or myocardial perfusion measured with MRI in cancer patients receiving chemotherapy.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 阿霉素会延长生存率并减轻许多患有癌症的儿童和成人的肿瘤负担，但其使用可能会导致不可逆的充血性心力衰竭（CHF）。赫赛汀，紫杉醇和环磷酰胺也是广泛用于癌症的药物，与心脏毒性有关。 尽管在化学疗法过程中检测到的左心室射血（LVEF）可能会预测CHF的发作，但它可能仅在无法可逆的心脏损伤持续后才发生。 最近，心血管磁共振成像（MRI）已用于量化 左心室舒张性区域放松的区域变化。 对儿童的研究有 经常接受阿霉素疗法的患者的LV舒张功能的变化 在左心室射血分数中的恶化之前。 从我们的飞行员数据 机构表示，MRI可用于检测左心室放松异常 LVEF程度不同的患者。 我们的目的是确定心脏毒性与左心室舒张压弛豫的降低或在接受化学疗法的癌症患者中测量的MRI的心肌灌注之间的关联。