ELECTRICAL IMPEDANCE MYOGRAPHY IN ALS

ALS 中的电阻抗肌电图检查

• 批准号: 8167023
• 负责人: JAMES B CARESS
• 金额: $ 1.21万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-01 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167023
• 关键词: Amyotrophic Lateral Sclerosis; Breathing; Computer Retrieval of Information on Scientific Projects Database; Data; Deterioration; Disease Progression; Enrollment; Funding; Goals; Grant; Institution; Measures; Methods; Muscle; Myography; Nerve; Outcome Measure; Painless; Patients; Research; Research Personnel; Resources; Source; Surveys; Testing; United States National Institutes of Health; electric impedance; functional status

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Trials evaluating new therapies for stopping or slowing the progression of amyotrophic lateral sclerosis (ALS) depend critically upon the use of outcome measures to assess whether a potential treatment is effective. The more effective an outcome measure, the fewer patients need to be enrolled and the shorter the trial. Many outcome measures have been used over the years, including strength assessments, breathing tests, functional status surveys, and nerve testing, but all are far from ideal. A new method, called electrical impedance myography (EIM) appears to be especially promising in that it provides very consistent data from one testing session to the next, is sensitive to the muscle deterioration that occurs in ALS, and is entirely painless and non-invasive. In this study, investigators from multiple institutions plan to compare several different outcome measures, including EIM, in approximately 120 ALS patients, with each patient being followed for a period of one year. All of these measures will be compared to one another and an assessment of their ability to detect disease progression made. Our goal will be to determine whether EIM can serve as a valuable new outcome measure, ultimately leading to substantially faster, more effective ALS trials requiring fewer patients.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 中心，不一定是研究者的机构。 评估阻止或减缓肌萎缩侧索硬化症（ALS）进展的新疗法的试验主要取决于使用结果指标来评估潜在治疗是否有效。结果测量越有效，需要入组的患者越少，试验时间也越短。多年来已经使用了许多结果测量方法，包括力量评估、呼吸测试、功能状态调查和神经测试，但都远非理想。一种称为电阻抗肌电图 (EIM) 的新方法似乎特别有前途，因为它从一个测试阶段到下一个测试阶段提供非常一致的数据，对 ALS 中发生的肌肉退化敏感，并且完全无痛且非侵入性。在这项研究中，来自多个机构的研究人员计划在大约 120 名 ALS 患者中比较几种不同的结果指标，包括 EIM，并对每位患者进行为期一年的随访。所有这些措施都将相互比较，并评估其检测疾病进展的能力。我们的目标是确定 EIM 是否可以作为一种有价值的新结果衡量标准，最终导致需要更少患者的更快、更有效的 ALS 试验。