Optimized Multi-Metabolite Edited MRS at 3T

3T 时优化的多代谢物编辑 MRS

• 批准号: 10054760
• 负责人: Mark Mikkelsen
• 金额: $ 8.59万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-15 至 2021-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10054760
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PROJECT SUMMARY Magnetic resonance spectroscopy (MRS) can noninvasively measure the concentration of endogenous metabolites in the body and brain. Lower-concentration metabolites have weaker MR signals and therefore are more difficult to detect. Edited MRS simplifies the MR spectrum so that these weaker signals can be more easily quantified. However, usually only a single metabolite is edited, leading to multiple scans and longer examination times when targeting multiple low-concentration metabolites. This project involves the development and implementation of a highly optimized multiplexed editing technique, termed sLASER-HERCULES, for the simultaneous detection of up to 8 low-concentration brain metabolites in a single scan. The reproducibility of this approach will be rigorously assessed in vivo in a cohort of adult subjects. Additionally, software algorithms based on spatially resolved density-matrix simulations and advanced statistics will be developed for optimizing the acquisition parameters of this MRS technique to improve the reliable measurement of specific groups of editable metabolites detectable by sLASER-HERCULES. The technologies generated from this project will improve the efficiency of edited MRS and its applicability to clinical MR exams and will ultimately allow multiple hypotheses to be tested from biochemical measurements collected in a single scan. The candidate will undertake tuition and training in MR physics, MRS acquisition methodology, and pulse programming to successfully implement the sLASER-HERCULES sequence. The training and research proposed in this project will be undertaken in a highly supportive institutional environment, with extensive resources available for research and professional support. The candidate will have access to state-of-the-art MR facilities and will be mentored by world leaders in MRS and MRI. The long-term career objective of the candidate is to establish himself as an independent early stage investigator with a complete repertoire of skills in MRS methodology and applications.

项目概要 磁共振波谱（MRS）可以无创地测量内源性物质的浓度 身体和大脑中的代谢物。较低浓度的代谢物具有较弱的 MR 信号，因此 更难被发现。编辑后的 ​​MRS 简化了 MR 频谱，使这些较弱的信号可以更容易地被识别 量化。然而，通常只编辑单个代谢物，导致多次扫描和更长的检查时间 靶向多种低浓度代谢物时的时间。该项目涉及开发和 实施高度优化的多重编辑技术，称为 sLASER-HERCULES，用于 在一次扫描中同时检测多达 8 种低浓度脑代谢物。这个的重现性 该方法将在一组成年受试者体内进行严格的体内评估。此外，基于软件算法 将开发关于空间分辨密度矩阵模拟和高级统计的技术，以优化 该 MRS 技术的采集参数可提高特定可编辑组的可靠测量 sLASER-HERCULES 可检测代谢物。该项目产生的技术将改善 编辑 MRS 的效率及其对临床 MR 检查的适用性，最终将允许多种假设 通过单次扫描收集的生化测量结果进行测试。候选人将承担学费和 MR 物理、MRS 采集方法和脉冲编程方面的培训，以成功实施 sLASER-HERCULES 序列。该项目中提出的培训和研究将在高度重视的情况下进行 支持性的制度环境，具有可用于研究和专业支持的广泛资源。 候选人将可以使用最先进的 MR 设施，并接受 MRS 领域世界领导者的指导 和核磁共振成像。候选人的长期职业目标是使自己成为一个独立的早期阶段 具有 MRS 方法和应用方面完整技能的研究者。