New Photo-Acoustic Imaging Process in Fetal Monitoring to Dramatically Reduce Brain Injuries in Newborns

胎儿监测中的新光声成像流程可显着减少新生儿脑损伤

基本信息

批准号：
10010328
负责人：
ChenChia Wang
金额：
$ 15万
依托单位：
BRIMROSE TECHNOLOGY CORPORATION
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-07-01 至 2021-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10010328
关键词：
Acoustics Adult Aluminum Animals Asphyxia Auscultation Biological Birth Blood Brain Brain Injuries Caregivers Cerebral Palsy Cerebral cortex Cerebral perfusion pressure Cerebrum Cesarean section Clinical Communities Detection Development Devices Discipline of Nursing Discipline of obstetrics Drug or chemical Tissue Distribution Early Diagnosis Early Intervention Early treatment Electricity Elements Engineering Evaluation Fetal Heart Rate Fetal Monitoring Fetus Gases Goals Hemoglobin Hybrids Hypoxia Imaging Device Impairment Incidence Infant Intention Intervention Ischemia Laboratories Lasers Legal patent Light Live Birth Machine Learning Maternal-fetal medicine Measurement Measures Medical Medicine Metabolic acidosis Methods Modeling Monitor Nature Neodymium Neonatal Neurologic Newborn Infant Noise Optics Oxyhemoglobin Pathway interactions Perinatal anoxic ischemic brain injury Phase Physiologic pulse Physiology Preparation Procedures Process Reporting Research Research Personnel Resolution Role Safety Sagittal Sinus Scalp structure Sensitivity and Specificity Signal Transduction Small Business Innovation Research Grant Source Specificity Structure of fontanel of skull System Technology Therapeutic Time Tissues Translations Ultrasonic wave Ultrasonography Universities Validation Veins Venous Yttrium absorption base bone cerebral oxygenation cerebral vein chromophore commercialization contrast imaging cost cranium detector disability energy density falls fetal fetal brain injury fetus at risk global health hazard heart rate monitor imaging system improved in silico in vivo innovation instrument intrapartum light scattering machine learning method microphone miniaturize mortality natural hypothermia neonatal brain neonatal hypoxic-ischemic brain injury novel photoacoustic imaging prevent prototype sensor simulation sound temporal measurement virtual

项目摘要

PROJECT SUMMARY Summary The Brimrose Technology Corporation and Johns Hopkins University are forming a powerful new team to make a new instrument that has the potential to dramatically reduce a major global health problem–perinatal hypoxic- ischemic encephalopathy (HIE)–by enabling early detection during labor. HIE caused by asphyxia is a leading cause of infant fatalities as well as a source of cerebral palsy and other long-term severe neurologic impairments. The medical community has been limited in early diagnosis of HIE because current fetal heart rate monitoring has poor specificity. If identified early, HIE can be treated effectively with therapeutic hypothermia. We are proposing a fetal photoacoustic monitoring system that measures oxyhemoglobin saturation of the sagittal sinus vein draining the fetal cerebral cortex during labor. Sagittal sinus oxyhemoglobin saturation decreases to very low levels when placental gas exchange is impaired (hypoxia) and/or when fetal cerebral perfusion pressure falls (ischemia). The photoacoustic instrument transmits light through the open fontanelle or bone and into cerebral veins and tissue where ultrasound waves are generated. Using near- infrared incident light at discrete wavelengths that are absorbed preferentially by oxy- and deoxy-hemoglobin, ultrasound detected on the fetal scalp at each wavelength can estimate oxyhemoglobin saturation. Brimrose has constructed a novel ultrasound detection technology with sensitivity orders of magnitude greater than the current best-use piezo-electric sensors. This will permit the use of low-power LED light sources rather than cumbersome laser lights now employed, thereby avoiding safety goggle use and promoting greater deployment. The Hopkins team has already validated the ability of a standard photoacoustic system to accurately estimate sagittal sinus oxyhemoglobin saturation through the skull of newborn piglets. The purpose of Phase I is to demonstrate the feasibility of using safe, low power LED light sources with the new ultrasensitive ultrasound sensor to detect critically low sagittal sinus oxyhemoglobin saturation when oxygenation is manipulated. The platform will be based on in-silico simulation to optimize the acoustic and optical pathways for the skull and brain. Real-time measurements on a time scale of seconds will inform the obstetric caregiver of dynamic fluctuations of brain oxygenation during contractions. The Phase II goal is to make a miniaturized photoacoustic device prototype that can report on fetal brain oxygenation. We believe the resulting instrument will provide early detection brain HI with greater specificity and sensitivity, enabling early intervention and treatment and is potentially transferrable to a commercial model for manufacture.

项目概要概括 Brimrose 科技公司和约翰霍普金斯大学正在组建一个强大的新团队，以制造一种新仪器有可能大大减少全球主要健康问题——围产期缺氧—— 缺血性脑病 (HIE)——通过在分娩过程中尽早发现由窒息引起的 HIE 是一种主要疾病。婴儿死亡的原因以及脑瘫和其他长期严重神经系统疾病的根源由于目前的胎儿心脏损伤，医学界对 HIE 的早期诊断受到限制。率监测的特异性较差，如果及早发现，HIE 可以通过治疗得到有效治疗。我们提出了一种测量氧合血红蛋白的胎儿光声监测系统。分娩过程中引流胎儿大脑皮层的矢状窦静脉的饱和度。当胎盘气体交换受损（缺氧）和/或胎儿时，饱和度会降至非常低的水平脑灌注压下降（缺血）。光声仪器通过开放的光线传输。使用近端波进入囟门或骨骼并进入脑静脉和组织。离散波长的红外入射光优先被氧合血红蛋白和脱氧血红蛋白吸收，在胎儿头皮上检测到的每个波长的超声波可以估计氧合血红蛋白饱和度。构建了一种新颖的超声波检测技术，其灵敏度比现有技术高出几个数量级目前最好用的压电传感器将允许使用低功率 LED 光源，而不是使用。现在使用笨重的激光灯，避免使用安全护目镜并促进更多霍普金斯大学团队已经验证了标准光声系统的能力。通过新生仔猪头骨准确估计矢状窦氧合血红蛋白饱和度的目的。第一阶段的目标是展示使用安全、低功耗 LED 光源和新型光源的可行性超灵敏超声波传感器可检测矢状窦氧合血红蛋白饱和度极低的情况该平台将基于计算机模拟来控制氧合，以优化声学和头骨和大脑的光学通路将以秒为单位进行实时测量。产科护理人员在宫缩期间脑氧合的动态波动。制作一个可以报告胎儿大脑氧合情况的小型光声设备原型。由此产生的仪器将提供具有更高特异性和灵敏度的早期检测大脑 HI，从而实现早期检测干预和治疗，并有可能转化为商业生产模式。

项目成果

期刊论文数量（1）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Ultrasound Signal Detection with Multi-bounce Laser Microphone.

使用多反射激光麦克风进行超声信号检测。

DOI：
发表时间：
2020-09
期刊：
影响因子：
0
作者：
Wan, Qianqian;Wang, ChenChia;Xu, Keshuai;Kang, Jeeun;Wu, Yixuan;Trivedi, Sudhir B;Gehlbach, Peter;Boctor, Emad
通讯作者：
Boctor, Emad