Self Healing Biomaterials

自愈生物材料

• 批准号: 8183634
• 负责人: William Montgomery Reichert
• 金额: $ 19.14万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-10 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8183634
• 关键词: Affect; Alloys; Area; Behavior; Biocompatible; Biocompatible Materials; Biological; Bone Cements; Chemistry; Chromium; Clinical; Clinical Medicine; Cobalt; Coupled; Cultured Cells; Cyanoacrylates; Drug Formulations; Encapsulated; Environment; Failure; Fatigue; Fibroblasts; Fracture; Goals; Healed; Human; Implant; In Situ; Infection; Inflammation; Lead; Life; Mechanics; Microcapsules drug delivery system; Modeling; Mus; Oils; Operative Surgical Procedures; Osteoblasts; Patients; Polyethylenes; Polymers; Polymethyl Methacrylate; Polytetrafluoroethylene; Polyurethanes; Property; Prunella vulgaris; Quality of life; Reporting; Sampling; Science; Silicone Elastomers; Stainless Steel; Surface; Techniques; Technology; Testing; Tissue Adhesives; Tissues; Titania; Titanium; Water; Weight-Bearing state; Wing; catalyst; clinically significant; cytotoxicity; cytotoxicity test; healing; implant material; innovation; interfacial; irritation; polymerization; prevent; repaired; seal; success

DESCRIPTION (provided by applicant): In situ repair of mechanical failure remains a largely unexamined area of study in biomaterials. A newly emerging area of materials science is "Self-Healing Materials" (SHM) that uses a variety of embedded chemistries to detect and repair microcracks in situ before they coalesce into propagating cracks. This R21 proposal examines the feasibility of incorporating biocompatible, non-toxic SHM technology into one of the simplest load-bearing biomaterial formulations -- two component acrylic bone cement -- with the most straightforward SHM technology -- microencapsulated healing agent dispersed in a catalyst-embedded polymer matrix. The study consists of four specific aims. Aim 1: Fabrication of microencapsulated alkyl cyanoacrylate healing agent using emulsified oil in water interfacial polymerization. Aim 2: Incorporation of the icroencapsulated healing agent into the two-component PMMA matrix. Aim 3: Characterization of self-healing bone cement mechanical properties and fracture mechanics. Aim 4: Cytotoxicity testing of self-healing bone cement by elution testing of extraction media in mouse fibroblast culture, and by cell ongrowth onto samples of bone cement placed in cultures of human osteoblasts. PUBLIC HEALTH RELEVANCE: The most likely mode of failure of all cyclically loaded biomaterials is fatigue failure resulting from the accumulation of microcracks. The long-term goal of this study is to develop composite biomaterials that have the capacity to repair failure at the microcrack level and thus prolong the use life of cyclically loaded biomaterials. This project specifically tests out the concept feasibility using acrylic bone cement as a model biomaterial.

描述（由申请人提供）：机械故障的原位修复仍然是生物材料研究的一个很大程度上未经检验的领域。材料科学的一个新兴领域是“自愈材料”（SHM），它使用各种嵌入式化学物质在微裂纹合并成扩展裂纹之前原位检测和修复微裂纹。该 R21 提案研究了将生物相容性、无毒 SHM 技术纳入最简单的承重生物材料配方之一（双组分丙烯酸骨水泥）的可行性，其中采用最简单的 SHM 技术（分散在催化剂中的微囊愈合剂）嵌入聚合物基质。该研究有四个具体目标。目的 1：利用水包油界面聚合法制备微胶囊氰基丙烯酸烷基酯愈合剂。目标 2：将微囊愈合剂纳入双组分 PMMA 基质中。目标 3：自愈骨水泥机械性能和断裂力学的表征。目标 4：通过对小鼠成纤维细胞培养物中的提取介质进行洗脱测试，以及通过细胞在置于人成骨细胞培养物中的骨水泥样品上生长来测试自愈骨水泥的细胞毒性。 公共健康相关性：所有循环加载生物材料最可能的失效模式是微裂纹累积导致的疲劳失效。这项研究的长期目标是开发具有修复微裂纹水平失效能力的复合生物材料，从而延长循环加载生物材料的使用寿命。该项目专门测试了使用丙烯酸骨水泥作为模型生物材料的概念可行性。