Self Healing Biomaterials

自愈生物材料

• 批准号: 8183634
• 负责人: William Montgomery Reichert
• 金额: $ 19.14万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-10 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8183634
• 关键词: Affect; Alloys; Area; Behavior; Biocompatible; Biocompatible Materials; Biological; Bone Cements; Chemistry; Chromium; Clinical; Clinical Medicine; Cobalt; Coupled; Cultured Cells; Cyanoacrylates; Drug Formulations; Encapsulated; Environment; Failure; Fatigue; Fibroblasts; Fracture; Goals; Healed; Human; Implant; In Situ; Infection; Inflammation; Lead; Life; Mechanics; Microcapsules drug delivery system; Modeling; Mus; Oils; Operative Surgical Procedures; Osteoblasts; Patients; Polyethylenes; Polymers; Polymethyl Methacrylate; Polytetrafluoroethylene; Polyurethanes; Property; Prunella vulgaris; Quality of life; Reporting; Sampling; Science; Silicone Elastomers; Stainless Steel; Surface; Techniques; Technology; Testing; Tissue Adhesives; Tissues; Titania; Titanium; Water; Weight-Bearing state; Wing; catalyst; clinically significant; cytotoxicity; cytotoxicity test; healing; implant material; innovation; interfacial; irritation; polymerization; prevent; repaired; seal; success

DESCRIPTION (provided by applicant): In situ repair of mechanical failure remains a largely unexamined area of study in biomaterials. A newly emerging area of materials science is "Self-Healing Materials" (SHM) that uses a variety of embedded chemistries to detect and repair microcracks in situ before they coalesce into propagating cracks. This R21 proposal examines the feasibility of incorporating biocompatible, non-toxic SHM technology into one of the simplest load-bearing biomaterial formulations -- two component acrylic bone cement -- with the most straightforward SHM technology -- microencapsulated healing agent dispersed in a catalyst-embedded polymer matrix. The study consists of four specific aims. Aim 1: Fabrication of microencapsulated alkyl cyanoacrylate healing agent using emulsified oil in water interfacial polymerization. Aim 2: Incorporation of the icroencapsulated healing agent into the two-component PMMA matrix. Aim 3: Characterization of self-healing bone cement mechanical properties and fracture mechanics. Aim 4: Cytotoxicity testing of self-healing bone cement by elution testing of extraction media in mouse fibroblast culture, and by cell ongrowth onto samples of bone cement placed in cultures of human osteoblasts. PUBLIC HEALTH RELEVANCE: The most likely mode of failure of all cyclically loaded biomaterials is fatigue failure resulting from the accumulation of microcracks. The long-term goal of this study is to develop composite biomaterials that have the capacity to repair failure at the microcrack level and thus prolong the use life of cyclically loaded biomaterials. This project specifically tests out the concept feasibility using acrylic bone cement as a model biomaterial.

描述（由申请人提供）：机械故障的原位修复仍然是生物材料中未经审查的研究领域。材料科学的新兴领域是“自我修复材料”（SHM），该材料使用各种嵌入式化学物质在原位检测和修复微裂纹，然后再合并以传播裂缝。该R21提案研究了将生物相容性的，无毒的SHM技术纳入最简单的承载生物材料配方之一 - 两种成分的丙烯酸骨水泥 - 具有最直接的SHM技术（最直接的SHM技术） - 微型囊化的愈合剂在A CatalySt-Embedded-Embedded Polymer Matrix中分散。该研究由四个具体目标组成。 AIM 1：在水界面聚合中使用乳化油制造微囊化烷基氰基丙烯酸酯愈合剂。 AIM 2：将Icrocapsed Healing剂掺入两个组件PMMA矩阵中。目标3：自我修复骨水泥机械特性和断裂力学的表征。 AIM 4：通过在小鼠成纤维细胞培养物中提取培养基的萃取培养基以及细胞的生长在人体成骨细胞培养物中的骨水泥样品中对自我修复骨水泥进行的细胞毒性测试。 公共卫生相关性：所有周期性生物材料的最可能失败方式是由微裂纹的积累导致的疲劳失败。这项研究的长期目标是开发具有在微裂料水平上修复衰竭的能力，从而延长周期载荷生物材料的使用寿命的能力。该项目使用丙烯酸骨水泥作为模型生物材料专门测试了概念可行性。