5th International Conference on Epithelial Mesenchymal Transition

第五届国际上皮间质转化会议

基本信息

批准号：
8129099
负责人：
RAYMOND Bruce RUNYAN
金额：
$ 0.9万
依托单位：
UNIVERSITY OF ARIZONA
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-05-01 至 2012-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8129099
关键词：
Adherence Adult Area Arizona Asia Atrial Heart Septal Defects Australia Basement membrane Brain Canada Cancer Biology Cell physiology Cells Child Consensus Cytoskeleton Data Development Developmental Process Discipline Disease Elements Embryo Embryology Epithelial Epithelial Cells Event Extracellular Matrix Family Fibrosis Funding Gene Expression Regulation Genetic Transcription Growth Factor Heart Heart Valves Indium International Invaded Investigation Islets of Langerhans Journals Kidney Malignant Neoplasms Mammary Neoplasms Mandibulofacial Dysostosis Mesenchymal Molecular Genetics Neoplasm Metastasis Neural Crest Neural Crest Cell Organ Organogenesis Orphan Disease Paper Pathology Patients Peptide Hydrolases Poland Postdoctoral Fellow Process Published Comment Publishing Rare Diseases Reagent Reporting Research Personnel Scientist Signal Transduction Singapore Snails Societies Students Syndrome Techniques Tissues Travel Tumor Tissue Uncertainty United States United States National Institutes of Health Update Vimentin Work Wound Healing base cancer stem cell epithelial to mesenchymal transition gastrulation interstitial malignant breast neoplasm meetings neoplastic cell outreach pancreatic neoplasm somitogenesis symposium three dimensional structure transcription factor tumor

项目摘要

DESCRIPTION (provided by applicant): The specific aim of this proposal is to obtain partial funding for the expenses (travel and lodging) for academic speakers and students from the USA to attend the Fifth International Meeting on Epithelial-Mesenchymal Transition. The meeting will be held Oct 10-13, 2011 in the Biopolis Center of Singapore under the auspices of the Epithelial-Mesenchymal Transition International Association (TEMTIA). The objectives of the meeting are to 1. Bring together investigators in the separate disciplines of cancer, pathology and development to discuss their observations on EMT and explore whether there is a consensus on important components of the process. 2. Provide a forum where students and junior investigators can interact with senior investigators and display their own work and ideas in the field. 3. Expand a viable co-operative cross- disciplinary forum of EMT-related researchers internationally, particularly with outreach to Asia. This will continue to provide a worldwide network for exchange of expertise, reagents and techniques across disciplines. 4. Publish a timely meeting update on cellular, molecular and genetic aspects of EMT in an appropriate cross-disciplinary international journal. Epithelial-mesenchymal transition (EMT) is a fundamental cellular process undertaken by cells in the embryo to form 3-dimensional structures from sheets of cells. During EMT, epithelial cells lose adherence to adjacent cells, degrade the local basement membrane and invade the underlying interstitial extracellular matrix. At the cellular level, this process requires specific signal transduction elements, new gene transcription, reorganization of the cytoskeleton, secretion of extracellular matrix molecules and growth factors. In the embryo, this process is reiterated at gastrulation, neural crest cell formation, somite breakdown, pancreatic islet formation, heart valve formation brain organization and in several other areas of organogenesis. In the adult, EMT occurs as a component of wound healing and in the pathologies of cancer metastasis and tissue fibrosis. PUBLIC HEALTH RELEVANCE: Support is requested for travel by academic US scientists to participate in a scientific meeting that brings together researchers exploring common aspects of cell invasion in development cancer and organ fibrosis. The field of epithelial mesenchymal transition is rapidly expanding and the conference will bring together groups who do not normally intersect.

描述（由申请人提供）：该提案的具体目的是为来自美国的学术演讲人和学生参加第五届上皮间质转化国际会议获得部分费用（旅行和住宿）资金。会议将于 2011 年 10 月 10 日至 13 日在新加坡 Biopolis 中心举行，由上皮间充质转化国际协会 (TEMTIA) 主办。会议的目标是 1. 将癌症、病理学和发育等不同学科的研究人员聚集在一起，讨论他们对 EMT 的观察，并探讨是否对该过程的重要组成部分达成共识。 2. 提供一个论坛，学生和初级研究者可以与高级研究者互动并展示自己在该领域的工作和想法。 3. 在国际上扩大与紧急医疗救护相关的研究人员的可行的跨学科合作论坛，特别是扩展到亚洲。这将继续提供一个全球网络，用于跨学科的专业知识、试剂和技术的交流。 4. 在适当的跨学科国际期刊上及时发布关于 EMT 的细胞、分子和遗传方面的会议更新。上皮-间质转化 (EMT) 是胚胎细胞从细胞片形成 3 维结构的基本细胞过程。在 EMT 过程中，上皮细胞失去与邻近细胞的粘附，降解局部基底膜并侵入下面的间质细胞外基质。在细胞水平上，这个过程需要特定的信号转导元件、新的基因转录、细胞骨架的重组、细胞外基质分子和生长因子的分泌。在胚胎中，这一过程在原肠胚形成、神经嵴细胞形成、体节分解、胰岛形成、心脏瓣膜形成、脑组织以及器官发生的其他几个领域中重复出现。在成人中，EMT 作为伤口愈合的一个组成部分以及癌症转移和组织纤维化的病理过程中发生。公共健康相关性：请求支持美国学术科学家前往参加一个科学会议，该会议汇集了研究人员，探讨癌症发展和器官纤维化中细胞侵袭的常见方面。上皮间质转化领域正在迅速扩大，会议将汇集通常不相交的群体。