2012 Thiol-based Redox Regulation & Signaling GRC and GRS

2012年硫醇基氧化还原调节

基本信息

批准号：
8252744
负责人：
LESLIE B POOLE
金额：
$ 0.75万
依托单位：
GORDON RESEARCH CONFERENCES
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-22 至 2012-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8252744
关键词：
Address Aging Amino Acids Animal Model Antioxidants Apoptosis Regulation Gene Area Bioinformatics Biological Models Biology Cell Cycle Regulation Cell Proliferation Cell physiology Cells Chemicals Chemistry Clinical Collaborations Communities Complex Cysteine Development Disease Doctor of Philosophy Elements Environment European Exposure to Flavoring France Functional disorder Generations Homeostasis Human International Italy Lead Link Location Maine Malignant Neoplasms Methodology Methods Modification Molecular Molecular Carcinogenesis New England Nitrogen Outcome Oxidation-Reduction Oxidative Stress Oxygen Pathologic Processes Pathway interactions Phosphoric Monoester Hydrolases Phosphorylation Phosphotransferases Physicians Physiological Processes Physiology Process Property Proteins Reaction Reactive Oxygen Species Regulation Request for Applications Request for Proposals Research Research Personnel Schedule Scientist Signal Transduction Site Stress Sulfhydryl Compounds Sulfur Technology Therapeutic Work age related base college disulfide bond environmental agent environmental toxicology frontier graduate student improved interest meetings member oxidation protein folding protein function public health relevance success symposium transcription factor tumor progression

项目摘要

DESCRIPTION (provided by applicant) This proposal requests support for the Fourth Gordon Research Conference (and first associated Gordon Research Seminar) on Thiol-based Redox Regulation and signaling to be held at Bates College in Lewiston, Maine, from July 28th to August 3rd, 2012. The subtitle of this conference, "Molecular Underpinnings of Redox Regulation and Oxidative Stress," reflects the focus of the upcoming meeting on the interplay between regulation of protein function and fundamental cellular processes through redox modifications on thiols, and the dysregulation that ensues under environmental conditions that exacerbate oxidative stress. Thiol-containing proteins are major antioxidants in cells, and reversible oxidation of thiols in phosphatases, kinases and transcription factors links thiol-based redox chemistry to phosphorylation-based signaling, cell proliferation, apoptosis, gene regulation, cell cycle control and other processes and pathways. Dysregulation of thiol-based redox homeostasis, for example by exposure to environmental agents which promote the generation of excessive damaging reactive oxygen species, may impart an element of irreversibility to redox regulation and has major implications for the onset and progression of cancer and complex age-related diseases. This interdisciplinary conference is in its fourth cycle after three very successful meetings in the U.S. (2006) and Italy (2008 and 2010), and will provide, as it has in the past, an important venue for the free exchange of ideas and methodologies among the molecular biologists and toxicologists, chemists and clinicians working on various aspects of the field. While the thematic area of the conference is broad-based, its relevance to environmental stress, carcinogenesis and the molecular basis for normal human physiology and disease is enormous. By bringing together investigators with varied expertise in biophysical methods, bioinformatics and animal model systems, with clinical researchers and physicians focused on disease processes, the meeting is expected to further stimulate collaborations and catalyze scientific progress as has been exemplified by the successes of the previous meetings. Public Health Relevance: Many cellular functions rely on processes that involve changes in redox properties of particular molecules within the cell, and the dysregulation of these processes is a major component of the onset and progression of aging and cancer. One amino acid, cysteine (which contains a thiol group), serves as a molecular switch and is central to these redox changes, although very few molecular details of which redox changes occur during normal and pathological processes are known. This conference brings together chemists, molecular biologists and toxicologists, and clinicians to promote the sharing of different levels of understanding of thiol-dependent processes and enable therapeutic benefits to be gained from our improved understanding.

描述（由申请人提供）该提案请求支持第四届戈登研究会议（以及第一次与戈登研究研讨会）有关基于硫醇的氧化还原法规和信号的支持，并于2012年8月28日至8月3日在缅因州刘易斯顿的贝茨学院举行。会议，“氧化还原调节和氧化应激的分子基础”，反映了即将举行的会议的重点，即通过对硫醇的氧化还原修饰的蛋白质功能调节与基本细胞过程之间的相互作用的重点。 Thiol-containing proteins are major antioxidants in cells, and reversible oxidation of thiols in phosphatases, kinases and transcription factors links thiol-based redox chemistry to phosphorylation-based signaling, cell proliferation, apoptosis, gene regulation, cell cycle control and other processes and pathways 。例如，基于硫醇的氧化还原稳态失调，例如，暴露于促进过度破坏性的活性氧的环境药物中，可能会赋予氧化还原调节的不可逆性元素，并对癌症的发作和复杂的年龄发展产生重大影响。相关疾病。这次跨学科会议是在美国（2006年）和意大利（2008年和2010年）的三场非常成功的会议之后，在其第四个周期中，并将像过去一样提供一个重要的场所，以免费交流思想和方法论的重要场所分子生物学家和毒理学家，化学家和临床医生从事该领域的各个方面。虽然会议的主题领域是基于广泛的，但与环境压力，癌变以及正常人类生理和疾病的分子基础相关。通过将生物物理方法，生物信息学和动物模型系统方面具有多种专业知识的研究人员与临床研究人员和专注于疾病过程的专业知识，预计会议有望进一步刺激合作并催化科学进步，这是先前会议的成功所证明的。公共卫生相关性：许多细胞功能依赖于涉及细胞内特定分子的氧化还原特性变化的过程，这些过程的失调是衰老和癌症发作和进展的主要组成部分。一种氨基酸，半胱氨酸（含有硫醇基），是一个分子开关，对于这些氧化还原变化是中心的，尽管已知氧化还原变化的分子细节很少，并且已知氧化还原变化。这次会议汇集了化学家，分子生物学家和毒理学家和临床医生，以促进对硫醇依赖过程的不同水平的共享，并从我们的改善理解中获得治疗益处。