2012 Aging, Biology of GRC & GRS

2012年GRC衰老、生物学

• 批准号: 8252634
• 负责人: NIR J BARZILAI
• 金额: $ 7万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-30 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8252634
• 关键词: Aging; Animal Model; Basic Science; Biological; Biological Models; Biology of Aging; California; Chronic Disease; Communication; Communities; Complex; CpG Islands; Development; Disease; Elderly; Epigenetic Process; Experimental Models; Faculty; Feedback; Fees; Functional disorder; Funding; Funding Agency; Future; Genetic; Genomics; Glean; Goals; Human; Human Genome; Individual; Inflammatory; International; Intervention; Knowledge; Longevity; Medical; Metabolic; Methylation; MicroRNAs; Molecular Genetics; Physiological; Postdoctoral Fellow; Preparation; Process; Quality of life; Recording of previous events; Regulation; Request for Applications; Research; Research Personnel; Series; Shapes; Societies; Testing; Time; Training; Training Support; Translational Research; Travel; Validation; Work; abstracting; age related; cohort; design; frailty; functional decline; graduate student; meetings; novel; posters; programs; psychologic; research study; senescence; social; successful intervention; symposium

DESCRIPTION (provided by applicant): The 2012 Gordon Research Conference (GRC) on Biology of Aging will be the twenty-eighth of its kind since inception of the series in 1962. This series is important because research in basic biology of aging has been poorly represented in the large society meetings that have traditionally maintained a major emphasis on gerontological issues and their medical, social and psychological ramifications. Consequently, basic science investigators have sought the GRC on Biology of Aging as the ideal forum for discussion of recent advances in the field, presentation of new experimental models, challenge of paradigms, networking and initiation of collaborative projects. More than at any previous time in the history of this symposium, however, the field is ready to begin to integrate translational research into the basic biology of aging in model organisms. Hence, the 2012 GRC on the Biology of Aging will focus on the "Genetic, epigenetic, inflammatory, and metabolic origins of aging." The program focuses on four major advances in the biology of aging in recent years, which have not been brought together previously in this or other similar conferences: epigenetic mechanisms, such as regulation by microRNAs and by genomic CpG island methylation; intra-uterine development; large, unbiased genomic screens in people with exceptional longevity; and, cellular dysfunction and senescence that predisposes to frailty, chronic diseases, and diminished healthspan. All of these greatly expand the horizons of aging research and suggest the pursuit of interventions that have the potential to enhance healthspan. While much of our knowledge about the biology of aging has derived from studies using model organisms, recently humans have become the subjects of experiments that test how well these mechanisms are conserved and how they impact age-related diseases. The goal for the future has to be both the successful validation in humans of information gleaned from model systems and the interrogation of the human genome using model systems. Therefore, reciprocal feedback between investigators in these diverse fields is one of the main objectives of the 2012 Biology of Aging GRC. To accomplish this objective, the 2012 GRC on the Biology of Aging will: 1) promote open discussion of critical questions with particular emphasis on novel mechanisms that could have important translational potential for human aging; 2) provide a forum for the discussion of state-of- the art advances in research in biology of aging; 3) facilitate exchange of ideas and communication of findings that could shape the future goals of the field; 4) promote networking, initiation of international cooperative efforts, and consortiums; and, 5) promote the integration of junior investigators into the established community of aging researchers. This last objective will be met by inclusion of a Gordon-Kenan Research Seminar dedicated to the intellectual and psychological preparation of trainees for full participation in the GRC to follow. PUBLIC HEALTH RELEVANCE: Project Narrative The 2012 Gordon Research Conference (GRC) on Biology of Aging will be the twenty-eighth of its kind since inception of the series in 1962. This series is important because research in basic biology of aging has been poorly represented in the large society meetings that have traditionally maintained a major emphasis on gerontological issues and their medical, social and psychological ramifications. More than at any previous time in the history of this symposium, however, the field is ready to begin to integrate translational research into the basic biology of aging in model organisms. Hence, the 2012 GRC on the Biology of Aging will focus on the "Genetic, epigenetic, inflammatory, and metabolic origins of aging." While much of our knowledge about the biology of aging has derived from studies using model organisms, recently humans have become the subjects of experiments that test how well these mechanisms are conserved and how they impact age-related diseases. One of the goal for the future has to be both the successful validation in humans of information gleaned from model systems and the interrogation of the human genome using model systems. Therefore, reciprocal feedback between investigators in these diverse fields is one of the main objectives of the 2012 Biology of Aging GRC. A second goal is to prepare the next generation of basic scientists for leading roles in the field of aging research. In order to assist our junior colleagues in taking full advantage of the GRC, we will offer a Gordon Research Seminar on the weekend of the GRC, which is intended to overcome intellectual and psychological roadblocks to full participation in the ensuing meeting.

说明（由申请人提供）：2012 年戈登衰老生物学研究会议 (GRC) 将是该系列会议自 1962 年创办以来的第 28 届。该系列会议很重要，因为衰老生物学的基础生物学研究一直很薄弱。出席传统上主要强调老年学问题及其医学、社会和心理影响的大型社会会议。因此，基础科学研究人员寻求将衰老生物学 GRC 作为讨论该领域最新进展、展示新实验模型、挑战范式、建立网络和启动合作项目的理想论坛。然而，该领域比本次研讨会历史上的任何一次都更准备好开始将转化研究整合到模型生物衰老的基础生物学中。因此，2012 年衰老生物学 GRC 将重点关注“衰老的遗传、表观遗传、炎症和代谢起源”。该项目重点关注近年来衰老生物学的四项重大进展，这些进展此前在本次会议或其他类似会议上尚未集中讨论：表观遗传机制，例如 microRNA 和基因组 CpG 岛甲基化的调节；子宫内发育；对长寿人群进行大规模、公正的基因组筛查；细胞功能障碍和衰老容易导致虚弱、慢性疾病和健康寿命缩短。所有这些都极大地拓展了衰老研究的视野，并建议寻求有可能延长健康寿命的干预措施。虽然我们关于衰老生物学的大部分知识都源自使用模式生物的研究，但最近人类已成为实验的对象，这些实验测试这些机制的保守程度以及它们如何影响与年龄相关的疾病。未来的目标必须是在人类中成功验证从模型系统收集的信息以及使用模型系统询问人类基因组。因此，这些不同领域的研究人员之间的相互反馈是 2012 年衰老生物学 GRC 的主要目标之一。为了实现这一目标，2012年衰老生物学GRC将：1）促进对关键问题的公开讨论，特别强调可能对人类衰老具有重要转化潜力的新机制； 2) 提供一个讨论衰老生物学研究最新进展的论坛； 3）促进思想交流和研究结果的交流，从而塑造该领域的未来目标； 4) 促进联网、发起国际合作努力和联盟； 5) 促进初级研究人员融入已建立的老龄化研究人员群体。最后一个目标将通过举办戈登-凯南研究研讨会来实现，该研讨会致力于为学员全面参与随后的 GRC 做好智力和心理准备。 公共健康相关性：项目叙述 2012 年衰老生物学戈登研究会议 (GRC) 将是自 1962 年该系列会议创办以来的第 28 届此类会议。该系列会议很重要，因为衰老生物学基础生物学研究很少有代表性在传统上主要强调老年学问题及其医学、社会和心理影响的大型社会会议中。然而，该领域比本次研讨会历史上的任何一次都更准备好开始将转化研究整合到模型生物衰老的基础生物学中。因此，2012 年衰老生物学 GRC 将重点关注“衰老的遗传、表观遗传、炎症和代谢起源”。虽然我们关于衰老生物学的大部分知识都源自使用模式生物的研究，但最近人类已成为实验的对象，这些实验测试这些机制的保守程度以及它们如何影响与年龄相关的疾病。未来的目标之一必须是在人类中成功验证从模型系统收集的信息，并使用模型系统询问人类基因组。因此，这些不同领域的研究人员之间的相互反馈是 2012 年衰老生物学 GRC 的主要目标之一。第二个目标是培养下一代基础科学家在衰老研究领域发挥领导作用。为了帮助我们的初级同事充分利用GRC，我们将在GRC周末举办戈登研究研讨会，旨在克服智力和心理障碍，全面参与随后的会议。