2012 Aging, Biology of GRC & GRS

2012年GRC衰老、生物学

• 批准号: 8252634
• 负责人: NIR J BARZILAI
• 金额: $ 7万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-30 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8252634
• 关键词: Aging; Animal Model; Basic Science; Biological; Biological Models; Biology of Aging; California; Chronic Disease; Communication; Communities; Complex; CpG Islands; Development; Disease; Elderly; Epigenetic Process; Experimental Models; Faculty; Feedback; Fees; Functional disorder; Funding; Funding Agency; Future; Genetic; Genomics; Glean; Goals; Human; Human Genome; Individual; Inflammatory; International; Intervention; Knowledge; Longevity; Medical; Metabolic; Methylation; MicroRNAs; Molecular Genetics; Physiological; Postdoctoral Fellow; Preparation; Process; Quality of life; Recording of previous events; Regulation; Request for Applications; Research; Research Personnel; Series; Shapes; Societies; Testing; Time; Training; Training Support; Translational Research; Travel; Validation; Work; abstracting; age related; cohort; design; frailty; functional decline; graduate student; meetings; novel; posters; programs; psychologic; research study; senescence; social; successful intervention; symposium; Aging; Animal Model; Basic Science; Biological; Biological Models; Biology of Aging; California; Chronic Disease; Communication; Communities; Complex; CpG Islands; Development; Disease; Elderly; Epigenetic Process; Experimental Models; Faculty; Feedback; Fees; Functional disorder; Funding; Funding Agency; Future; Genetic; Genomics; Glean; Goals; Human; Human Genome; Individual; Inflammatory; International; Intervention; Knowledge; Longevity; Medical; Metabolic; Methylation; MicroRNAs; Molecular Genetics; Physiological; Postdoctoral Fellow; Preparation; Process; Quality of life; Recording of previous events; Regulation; Request for Applications; Research; Research Personnel; Series; Shapes; Societies; Testing; Time; Training; Training Support; Translational Research; Travel; Validation; Work; abstracting; age related; cohort; design; frailty; functional decline; graduate student; meetings; novel; posters; programs; psychologic; research study; senescence; social; successful intervention; symposium

DESCRIPTION (provided by applicant): The 2012 Gordon Research Conference (GRC) on Biology of Aging will be the twenty-eighth of its kind since inception of the series in 1962. This series is important because research in basic biology of aging has been poorly represented in the large society meetings that have traditionally maintained a major emphasis on gerontological issues and their medical, social and psychological ramifications. Consequently, basic science investigators have sought the GRC on Biology of Aging as the ideal forum for discussion of recent advances in the field, presentation of new experimental models, challenge of paradigms, networking and initiation of collaborative projects. More than at any previous time in the history of this symposium, however, the field is ready to begin to integrate translational research into the basic biology of aging in model organisms. Hence, the 2012 GRC on the Biology of Aging will focus on the "Genetic, epigenetic, inflammatory, and metabolic origins of aging." The program focuses on four major advances in the biology of aging in recent years, which have not been brought together previously in this or other similar conferences: epigenetic mechanisms, such as regulation by microRNAs and by genomic CpG island methylation; intra-uterine development; large, unbiased genomic screens in people with exceptional longevity; and, cellular dysfunction and senescence that predisposes to frailty, chronic diseases, and diminished healthspan. All of these greatly expand the horizons of aging research and suggest the pursuit of interventions that have the potential to enhance healthspan. While much of our knowledge about the biology of aging has derived from studies using model organisms, recently humans have become the subjects of experiments that test how well these mechanisms are conserved and how they impact age-related diseases. The goal for the future has to be both the successful validation in humans of information gleaned from model systems and the interrogation of the human genome using model systems. Therefore, reciprocal feedback between investigators in these diverse fields is one of the main objectives of the 2012 Biology of Aging GRC. To accomplish this objective, the 2012 GRC on the Biology of Aging will: 1) promote open discussion of critical questions with particular emphasis on novel mechanisms that could have important translational potential for human aging; 2) provide a forum for the discussion of state-of- the art advances in research in biology of aging; 3) facilitate exchange of ideas and communication of findings that could shape the future goals of the field; 4) promote networking, initiation of international cooperative efforts, and consortiums; and, 5) promote the integration of junior investigators into the established community of aging researchers. This last objective will be met by inclusion of a Gordon-Kenan Research Seminar dedicated to the intellectual and psychological preparation of trainees for full participation in the GRC to follow. PUBLIC HEALTH RELEVANCE: Project Narrative The 2012 Gordon Research Conference (GRC) on Biology of Aging will be the twenty-eighth of its kind since inception of the series in 1962. This series is important because research in basic biology of aging has been poorly represented in the large society meetings that have traditionally maintained a major emphasis on gerontological issues and their medical, social and psychological ramifications. More than at any previous time in the history of this symposium, however, the field is ready to begin to integrate translational research into the basic biology of aging in model organisms. Hence, the 2012 GRC on the Biology of Aging will focus on the "Genetic, epigenetic, inflammatory, and metabolic origins of aging." While much of our knowledge about the biology of aging has derived from studies using model organisms, recently humans have become the subjects of experiments that test how well these mechanisms are conserved and how they impact age-related diseases. One of the goal for the future has to be both the successful validation in humans of information gleaned from model systems and the interrogation of the human genome using model systems. Therefore, reciprocal feedback between investigators in these diverse fields is one of the main objectives of the 2012 Biology of Aging GRC. A second goal is to prepare the next generation of basic scientists for leading roles in the field of aging research. In order to assist our junior colleagues in taking full advantage of the GRC, we will offer a Gordon Research Seminar on the weekend of the GRC, which is intended to overcome intellectual and psychological roadblocks to full participation in the ensuing meeting.

描述（由申请人提供）：自1962年该系列的启用以来，关于衰老生物学的2012年戈登研究会议（GRC）将是二十八分之一。这个系列很重要，因为在衰老基本生物学的基本生物学研究中，在传统上一直在大型社会会议上表现不佳，传统上对老年学问题和社会学问题和社交学和精神学和精神病学的态度保持了重大强调。因此，基础科学研究者已寻求有关衰老生物学的GRC，这是讨论该领域进展，新实验模型，范式挑战，网络和协作项目的启动的理想论坛。然而，该领域比以前的任何时间都多于在模型生物体中衰老的基本生物学中的转化研究。因此，2012年关于衰老生物学的GRC将集中于“衰老的遗传，表观遗传，炎症和代谢起源”。该计划的重点是近年来衰老生物学的四个主要进步，这些进步在此或其他类似会议上以前尚未汇总在一起：表观遗传机制，例如microRNAS和基因组CPG岛甲基化的调节；内部发育；具有寿命卓越的人的大而公正的基因组筛选；以及易于脆弱，慢性疾病和健康状态减少的细胞功能障碍和衰老。所有这些都大大扩展了老化研究的视野，并提出了采取有可能增强健康范围的干预措施。尽管我们对使用模型生物的研究得出的有关衰老生物学的许多知识最近已成为实验的主题，它们测试了这些机制的保守程度以及它们如何影响与年龄相关的疾病。未来的目标必须是在人类中成功验证从模型系统收集的信息，又是使用模型系统对人类基因组进行询问。因此，这些不同领域的研究人员之间的相互反馈是2012年衰老GRC生物学的主要目标之一。为了实现这一目标，2012年关于衰老的生物学的GRC将：1）促进对关键问题的公开讨论，特别着重于新机制，这些机制可能具有重要的人类衰老的转化潜力； 2）为讨论衰老生物学研究的最新进展提供了一个论坛； 3）促进思想的交流和发现可能塑造该领域未来目标的发现的交流； 4）促进网络，国际合作努力的启动和财团； 5）促进初级研究人员将纳入老龄化研究人员社区的融合。将通过戈登 - 肯南研究研讨会来实现这一目标，该研讨会致力于学员的智力和心理准备，以充分参与GRC。 公共卫生相关性：项目叙事2012年戈登研究会议（GRC）关于衰老的生物学会议将是自1962年该系列系列成立以来的二十八分之一。这个系列很重要，因为在衰老基本生物学的基本生物学研究中，大型社会会议的代表性很差，这些社会会议传统上一直持续着重于老年人和社会学问题和社会学问题和社会学问题。然而，该领域比以前的任何时间都多于在模型生物体中衰老的基本生物学中的转化研究。因此，2012年关于衰老生物学的GRC将集中于“衰老的遗传，表观遗传，炎症和代谢起源”。尽管我们对使用模型生物的研究得出的有关衰老生物学的许多知识最近已成为实验的主题，它们测试了这些机制的保守程度以及它们如何影响与年龄相关的疾病。未来的目标之一必须是在人类中成功验证从模型系统收集的信息，又是使用模型系统对人类基因组进行询问。因此，这些不同领域的研究人员之间的相互反馈是2012年衰老GRC生物学的主要目标之一。第二个目标是准备下一代基础科学家在衰老研究领域的领导角色。为了帮助我们的初级同事充分利用GRC，我们将在GRC的周末提供戈登研究研讨会，该研讨会旨在克服智力和心理障碍，以充分参加随后的会议。