Training in Hantavirus Ecology, Virology & Clinical Investigation in the Americas

汉坦病毒生态学、病毒学培训

• 批准号: 7791373
• 负责人: Gregory James Mertz
• 金额: $ 12.39万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7791373
• 关键词: Address; Alabama; Americas; Andes Virus; Area; Argentina; Breathing; Cardiopulmonary; Categories; Chile; Clinical Research; Clinical Trials; Communicable Diseases; Critical Care; Disease; Disease Outbreaks; Doctor of Philosophy; Ecology; Feces; Fellowship; Funding; Future; Grant; Hantavirus; Hantavirus Infections; Infectious Diseases Research; New Mexico; Panama; Persons; Postdoctoral Fellow; Program Research Project Grants; Public Health Schools; RNA Viruses; Reporting; Research; Research Institute; Research Personnel; Research Training; Rodent; Students; Syndrome; Technology Transfer; Training; Training Activity; Training Programs; Training Support; Universities; Urine; Virus; clinical care; experience; man; meetings; member; programs; virology

DESCRIPTION (provided by applicant): Hantaviruses are RNA viruses that are harbored by specific rodent species and are transmitted to man via inhalation of virus-contaminated rodent feces and urine. In the Americas, several hantaviruses are now recognized as etiological agents of hantavirus cardiopulmonary syndrome (HCPS), which has a high case- fatality ratio. Etiologic agents of HCPS are Category A bioweapon threats. Andes virus-associated HCPS in Chile and Argentina is unique among hantaviruses in that it can be transmitted person-to-person. Hantavirus disease was first recognized in the Western Hemisphere in 1993, so there is an urgent need to build expertise in the Americas in rodent ecology, virology, clinical care, and clinical research as it relates to hantavirus infections in the Americas. Our group of U.S. and Chilean investigators has collaborated in hantavirus research, training and technology transfer since 1997, and multiple members of the team contributed to expansion of our research and training to Panama when it experienced its first outbreak of HCPS in 2000. We have had an ICIDR program project grant and a Fogarty ABC training program since 1999, with a track record of successful short- and long-term training of students at multiple levels. In 2004 we obtained supplemental funding through the Global Infectious Disease Research Training Program for a post- doctoral fellowship, and the ICIDR program project grant has been renewed through 2010. In this competitive renewal, our specific aims are to: 1) provide long-term training, including Ph.D., MPH, infectious diseases and critical care and post-doctoral fellowship training at the University of New Mexico, the University of Alabama and Southern Research Institute in areas that will increase the research capacity of the collaborating academic centers in Chile and Panama, 2) provide short-term training at the University of New Mexico, the University of Alabama at Birmingham, the Johns Hopkins University School of Public Health, Catholic University in Santiago, Chile and Universidad del Desarrollo in Santiago, Chile to address specific training needs for the UNM/Chile/Panama ICIDR program, and 3) conduct an annual research and training meeting, jointly supported by this training grant and UNM/Chile/Panama, for team building, to review progress in the research and training activities, for trainees and investigators to report on their projects, and to plan future research and training activities.

描述（由申请人提供）：汉坦病毒是由特定啮齿动物物种含有的RNA病毒，并通过吸入污染病毒污染的啮齿动物粪便和尿液而传播给人。在美洲，现在几种汉坦病毒被认为是汉塔病毒心肺综合征（HCPS）的病因学药物，其病例死亡比率很高。 HCP的病因学剂是生物武器威胁类别的类别。智利和阿根廷与安第斯山脉病毒相关的HCP在汉坦病毒中是独一无二的，因为它可以传播到人。汉塔病毒病于1993年首次在西半球得到认可，因此迫切需要在啮齿动物生态学，病毒学，临床护理和临床研究中建立美洲专业知识，因为它与美洲的hantavirus感染有关。自1997年以来，我们的美国和智利调查人员一直在Hantavirus研究，培训和技术转移方面合作，该团队的多个成员在2000年经历了HCP的第一次爆发时，有助于扩展我们的研究和培训。我们已经进行了ICIDR计划Grant和Fogarty ABC培训计划，自1999年以来，他们的Short Short Short Short-Record of Short-Record tears torke sarke nark-Record corvect of Squorts又有了多个学期的培训。 2004年，我们通过全球传染病研究培训计划获得了辅助资金，用于博士后奖学金，ICIDR计划项目赠款已于2010年续签。在这一竞争性更新中，我们的具体目的是：1）提供长期的培训，包括Ph.D.，包括Ph.D.，MPH，MPH，感染性疾病和感染后的培训培训，是培训的培训，并将其培训为新的培训，并将其研究开学，该大学的新学业，该大学的新学院，是新的培训。 Institute in areas that will increase the research capacity of the collaborating academic centers in Chile and Panama, 2) provide short-term training at the University of New Mexico, the University of Alabama at Birmingham, the Johns Hopkins University School of Public Health, Catholic University in Santiago, Chile and Universidad del Desarrollo in Santiago, Chile to address specific training needs for the UNM/Chile/Panama ICIDR program, and 3) conduct an annual research以及由这笔培训赠款和UNM/智利/巴拿马共同支持的培训会议，供团队建设，审查研究和培训活动的进度，供受训者和调查人员报告其项目，并计划未来的研究和培训活动。

项目成果

Use of IgG avidity to indirectly monitor epizootic transmission of sin nombre virus in deer mice (Peromyscus maniculatus).

利用 IgG 亲和力间接监测鹿鼠（Peromyscus maniculatus）中罪名病毒的流行性传播。

• 发表时间: 2006
• 期刊: The American journal of tropical medicine and hygiene
• 作者: Safronetz,David;Lindsay,Robbin;Hjelle,Brian;Medina,RafaelA;Mirowsky-Garcia,Katy;Drebot,MichaelA
• 通讯作者: Drebot,MichaelA