Exposure to PFNA and other PFAS in drinking water and associations with health-related outcomes in Gloucester County NJ

新泽西州格洛斯特县饮用水中 PFNA 和其他 PFAS 的暴露及其与健康相关结果的关联

• 批准号: 10021521
• 负责人: ROBERT John LAUMBACH
• 金额: $ 100万
• 依托单位: RBHS-SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-30 至 2024-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10021521
• 关键词: Exposure; PFNA; other; PFAS; drinking

PROJECT SUMMARY The Agency for Toxic Substances and Disease Registry (ATSDR) has identified the need for additional epidemiological research on the health effects of poly- and perfluoroalkyl substances (PFAS) exposures, particularly from contaminated drinking water and for compounds even less studied than perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS), such as perfluorononanoic acid (PFNA). The highest levels of PFNA contamination in public and private water wells recorded anywhere in the world were found in Paulsboro and West Deptford New Jersey, where measurable levels of other poly- and perfluoroalkyl substances (PFAS) were also detected. Contaminated drinking water is an important and growing source of exposure to PFNA and other PFAS, and it estimated that millions of adults and children are exposed to PFAS in drinking water. Associations between serum PFAS levels in the general population and a wide range of health effects have been reported, but relatively little is known about health effects from consuming water contaminated with PFAS. There is a critical need to better understand the health hazards and risks of PFNA and other PFAS in drinking water. The main objective of this proposal is to evaluate associations between health outcomes and multiple estimates of exposure to PFNA and other PFAS among members of these communities and the other study sites in a multi-site study. A number of hypotheses will be tested, including that exposure to PFNA and other PFAS are associated with blood lipid levels, renal function and kidney disease, thyroid hormones and disease, liver function and disease, glycemic parameters and diabetes, and immune response and function in both children and adults. Additional hypothesized effects to be studied include differences in sex hormones and sexual maturation, vaccine response, and neurobehavioral outcomes in children, as well as cardiovascular disease, osteoarthritis and osteoporosis, endometriosis, and autoimmune disease in adults. The rationale for these multiple cross-sectional analyses is to test hypotheses for which there is sufficient statistical power based on prior reports, to develop new hypotheses, and to build a foundation for future knowledge generation with members of these communities. As part of the multi-site study with a target enrollment of 6,000 adults and 2000 children, 1,000 adults and 350 children from the Paulsboro and West Deptford municipalities who consumed water from wells contaminated with PFNA and other PFAS will be enrolled. Assessment of exposure to PFAS will be based on blood concentrations of PFAS and drinking water exposure reconstruction and PBPK modeling of internal exposure, including development of novel models for PFNA. Estimation of associations between health outcomes and measured and modeled exposure to PFAS will be done for this site and across sites of this multi-site study. The proposed project is relevant to public health, because our results will strengthen the evidence basis for making decisions about policies and actions to protect human health when people may be exposed to PFAS from drinking water.

项目概要 有毒物质和疾病登记局 (ATSDR) 已确定需要额外的 关于多氟烷基物质和全氟烷基物质（PFAS）暴露对健康影响的流行病学研究， 特别是来自受污染的饮用水和比全氟辛酸研究更少的化合物 (PFOA)和全氟辛烷磺酸(PFOS)，例如全氟壬酸(PFNA)。最高级别 世界各地记录的 PFNA 污染公共和私人水井被发现于 新泽西州保罗斯伯勒和西德特福德，可测量到其他多氟烷基和全氟烷基的含量 还检测到了 PFAS 物质。受污染的饮用水是一个重要且日益增长的水源 接触 PFNA 和其他 PFAS，估计有数百万成人和儿童接触 PFAS 在饮用水中。一般人群血清 PFAS 水平与多种疾病之间的关联 对健康的影响已有报道，但人们对饮水对健康的影响知之甚少 被 PFAS 污染。迫切需要更好地了解 PFNA 的健康危害和风险 以及饮用水中的其他 PFAS。该提案的主要目标是评估之间的关联 这些成员的健康结果以及对 PFNA 和其他 PFAS 暴露的多重估计 社区和多地点研究中的其他研究地点。将测试许多假设，包括 接触 PFNA 和其他 PFAS 与血脂水平、肾功能和肾功能有关 疾病、甲状腺激素和疾病、肝功能和疾病、血糖参数和糖尿病，以及 儿童和成人的免疫反应和功能。有待研究的其他假设效应 包括性激素和性成熟、疫苗反应和神经行为结果的差异 儿童以及心血管疾病、骨关节炎和骨质疏松症、子宫内膜异位症和自身免疫性疾病 成人疾病。这些多重横截面分析的基本原理是检验以下假设： 基于先前的报告有足够的统计能力来提出新的假设并建立一个 为未来与这些社区成员共同创造知识奠定了基础。作为多地点研究的一部分 目标入学人数为 6,000 名成人和 2000 名儿童，来自 Paulsboro 的 1,000 名成人和 350 名儿童 和西德特福德市饮用被 PFNA 和其他 PFAS 污染的水井的水 将被录取。 PFAS 暴露评估将基于 PFAS 的血液浓度和饮酒情况 水暴露重建和内部暴露的 PBPK 建模，包括开发新颖的 PFNA 模型。估计健康结果与测量和建模暴露之间的关联 将针对该站点以及该多站点研究的跨站点进行 PFAS 检测。拟议项目涉及 公共卫生，因为我们的结果将加强制定政策和决策的证据基础 当人们可能通过饮用水接触 PFAS 时，采取行动保护人类健康。