Transcription cofactors in differentiation

分化中的转录辅助因子

• 批准号: 8197898
• 负责人: Yang Shi
• 金额: $ 43.69万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8197898
• 关键词: Ablation; Adult; Affect; Apoptosis; Base Sequence; Biochemical; Biology; Caenorhabditis elegans; Cell Maintenance; Cell physiology; Cellular biology; Chromatin; Chromatin Structure; Chromosomes; DNA Damage; DNA Repair; DNA damage checkpoint; Defect; Development; Double Strand Break Repair; Enhancers; Enzymes; Eukaryota; Fertility; Funding; Gene Mutation; Gene Targeting; Genes; Genetic; Genetic Transcription; Germ Cells; Heterochromatin; Histone H3; Histones; Homologous Gene; In Vitro; Infertility; Length; Light; Link; Lysine; Maintenance; Meiosis; Methodology; Methylation; Microarray Analysis; Modeling; Modification; Molecular; Molecular Genetics; Morphogenesis; N-terminal; Nature; Pattern; Play; Post-Translational Protein Processing; Predisposition; Process; Prophase; Protein Family; Proteins; RNA Interference; Regulation; Reporting; Role; Specificity; Sterility; Substrate Specificity; Tail; Technology; Telomere Length Maintenance; Telomere Maintenance; Transcriptional Regulation; Yeasts; base; chromatin immunoprecipitation; cofactor; histone modification; in vivo; insight; interest; methyl group; mutant; protein complex; repaired; research study; response; telomere; tumorigenesis; yeast two hybrid system

项目成果

Developmental roles of the histone lysine demethylases.

• DOI: 10.1242/dev.020966
• 发表时间: 2009-03
• 期刊: Development (Cambridge, England)
• 作者: Nottke A;Colaiácovo MP;Shi Y
• 通讯作者: Shi Y

Histone methylation: a dynamic mark in health, disease and inheritance.

• DOI: 10.1038/nrg3173
• 发表时间: 2012-04-03
• 期刊: Nature reviews. Genetics

Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases.

• DOI: 10.1038/nsmb.1753
• 发表时间: 2010-01
• 期刊: Nature structural & molecular biology
• 影响因子: 16.8

ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome.

• DOI: 10.1038/nsmb.2062
• 发表时间: 2011-06-12
• 期刊: NATURE STRUCTURAL & MOLECULAR BIOLOGY
• 影响因子: 16.8
• 作者: Iwase, Shigeki;Xiang, Bin;Ghosh, Sharmistha;Ren, Ting;Lewis, Peter W.;Cochrane, Jesse C.;Allis, C. David;Picketts, David J.;Patel, Dinshaw J.;Li, Haitao;Shi, Yang
• 通讯作者: Shi, Yang

Stimulation of p300-mediated transcription by the kinase MEKK1.

激酶 MEKK1 刺激 p300 介导的转录。

• DOI: 10.1074/jbc.m008113200
• 发表时间: 2001
• 期刊: The Journal of biological chemistry
• 作者: See,RH;Calvo,D;Shi,Y;Kawa,H;Luke,MP;Yuan,Z;Shi,Y
• 通讯作者: Shi,Y