Effects of DLPFC tDCS on Cognition, Oscillations and GABA Levels in Schizophrenia

DLPFC tDCS 对精神分裂症认知、振荡和 GABA 水平的影响

• 批准号: 10017323
• 负责人: Cameron S. Carter
• 金额: $ 50.09万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-12 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10017323
• 关键词: Address; Adult; Affect; Anodes; Area; Attention; Behavioral Paradigm; Biological; Brain; Cognition; Cognitive deficits; Data; Development; Disease; Dose; Economic Burden; Electrophysiology (science); Equilibrium; Expectancy; Failure; Functional disorder; Goals; Human; Impaired cognition; Impairment; Individual; Intuition; Link; Literature; Magnetic Resonance Spectroscopy; Maintenance; Measures; Mediation; Mental disorders; Meta-Analysis; Methods; Modeling; National Institute of Mental Health; Occipital lobe; Occupational; Outcome; Pattern; Performance; Prefrontal Cortex; Process; Research; Rest; Role; Schizophrenia; Site; Specificity; Task Performances; Techniques; Testing; Time; Work; base; brain circuitry; cognitive control; cognitive disability; cognitive neuroscience; cognitive performance; cognitive task; daily functioning; design; effective therapy; efficacy testing; electric field; frontal lobe; gamma-Aminobutyric Acid; improved; insight; neural network; neuroimaging; neuromechanism; psychotic symptoms; relating to nervous system; social; support network; therapy development; tool

PROJECT SUMMARY/ABSTRACT Cognitive control deficits are associated with poor functioning in schizophrenia (SZ). These deficits include an impaired ability to maintain task-relevant goals and attention to a task over time, and are connected to impaired functioning of the dorsolateral prefrontal cortex (DLPFC), a key hub in the neural network supporting cognitive control. The proposed research uses a non-invasive brain stimulation technique, transcranial direct current stimulation (tDCS) to test a set of mechanistic hypotheses about the role of the DLPFC in cognitive control deficits in SZ, focusing on stimulation-induced changes in neural oscillations and DLPFC GABA levels. To do so, we will use DLPFC-targeted tDCS in combination with electrophysiology (EEG) and magnetic resonance spectroscopy (MRS) methods to examine stimulation-induced changes in neural activity related to cognitive control in SZ. Preliminary data from our lab suggests that DLPFC-targeted anodal tDCS can enhance neural oscillations that support goal maintenance in both healthy controls and individuals with SZ. This neurostimulation approach offers an exciting new avenue for understanding the neural mechanisms underlying impaired cognition in SZ, which we propose to utilize with three specific aims. Aim 1: Compare the effects of task-engaged versus resting tDCS in order to optimize the impact of tDCS on goal maintenance related neural oscillatory activity and task performance in SZ. Aim 2: Establish the regional specificity of the impact of DLPFC tDCS (compared to Occipital tDCS) effects on brain circuitry underlying goal maintenance in SZ. Aim 3: Test hypotheses about relationships between tDCS effects on DLPFC GABA levels, DLPFC-related oscillatory activity and cognitive performance in SZ. Successful completion of these Aims will address critical gaps in the literature on cognitive disability in SZ, which has, to date, relied on correlative approaches and will provide new insights into the role of disrupted DLPFC related brain circuity in SZ and its underlying pathophysiological mechanisms. It will also provide important new insights into the mechanisms of tDCS effects on brain and cognition in this illness.

项目概要/摘要 认知控制缺陷与精神分裂症 (SZ) 的功能不良有关。这些赤字包括 随着时间的推移，维持与任务相关的目标和对任务的注意力的能力受损，并且与受损有关 背外侧前额皮质 (DLPFC) 的功能，它是支持认知的神经网络的关键枢纽 控制。拟议的研究使用非侵入性脑刺激技术，经颅直流电 刺激 (tDCS) 来测试一组有关 DLPFC 在认知控制中的作用的机制假设 SZ 缺陷，重点关注刺激引起的神经振荡和 DLPFC GABA 水平的变化。要做的事 因此，我们将结合电生理学 (EEG) 和磁共振使用针对 DLPFC 的 tDCS 光谱（MRS）方法检查刺激引起的与认知相关的神经活动变化 控制在SZ。我们实验室的初步数据表明，针对 DLPFC 的阳极 tDCS 可以增强神经功能 支持健康对照者和精神分裂症患者维持目标的振荡。这 神经刺激方法为理解潜在的神经机制提供了一个令人兴奋的新途径 SZ 中的认知受损，我们建议将其用于三个具体目标。目标 1：比较效果 任务投入型 tDCS 与静息型 tDCS 的比较，以优化 tDCS 对目标维持相关神经的影响 SZ 中的振荡活动和任务绩效。目标 2：确定 DLPFC 影响的区域特殊性 tDCS（与枕叶 tDCS 相比）对 SZ 目标维持的大脑回路的影响。目标 3：测试 关于 tDCS 对 DLPFC GABA 水平、DLPFC 相关振荡的影响之间关系的假设 SZ 的活动和认知表现。成功完成这些目标将弥补 关于深圳认知障碍的文献，迄今为止，该文献依赖于相关方法，并将提供新的 深入了解 DLPFC 相关脑回路在 SZ 中的作用及其潜在的病理生理学 机制。它还将为 tDCS 对大脑和神经系统影响的机制提供重要的新见解。 对这种疾病的认识。