Adrenal Androgen Excess in PCOS: Role of Genetics

PCOS 患者肾上腺雄激素过多：遗传学的作用

• 批准号: 8197625
• 负责人: Ricardo Azziz
• 金额: $ 22.87万
• 依托单位: AUGUSTA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-05-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8197625
• 关键词: Acute; Adrenal Glands; Affect; Alabama; Anabolism; Androgen Metabolism; Androgens; Androstenedione; Area; Brothers; Candidate Disease Gene; Cardiovascular Diseases; Circadian Rhythms; Code; Complex; Complex Genetic Trait; Correlation Studies; Cortisone; DNA; Data; Defect; Dehydroepiandrosterone Sulfate; Development; Diabetes Mellitus; Disease; Economic Burden; Enzymes; Epidemiologic Studies; Epidemiology; Estrogens; Experimental Designs; Family; Family member; Fathers; Functional disorder; Funding; Genes; Genetic; Genetic Determinism; Genetic Variation; Genotype; Goals; Haplotypes; Heritability; Hirsutism; Hormones; Human Chorionic Gonadotropin; Husband; Hydrocortisone; Hyperinsulinism; Individual; Infertility; Inherited; Insulin; Insulin Resistance; International; Intrinsic factor; Knowledge; Leadership; Lymphocyte; Measurement; Measures; Medical; Metabolism; Mothers; Obesity; Oligonucleotides; Ovarian; Ovariectomy; Ovary; Ovulation; Pathway interactions; Patients; Phenotype; Play; Polycystic Ovary Syndrome; Principal Investigator; Production; Productivity; Progress Reports; Proteins; Public Health; Recruitment Activity; Research; Research Personnel; Risk; Role; Sampling; Single Nucleotide Polymorphism; Sister; Spouses; Steroid biosynthesis; Steroids; Structure; Testing; Testosterone; United States National Institutes of Health; Universities; Up-Regulation; Variant; Wife; Woman; acquired factor; adrenal hyperplasia; aged; analog; base; case control; cohort; cost; dehydroepiandrosterone; dehydroepiandrosterone sulfotransferase; experience; genetic analysis; genetic association; genetic risk factor; genetic variant; hypothalamic-pituitary-adrenal axis; in vivo; innovation; insight; lymphoblastoid cell line; member; multidisciplinary; novel; proband; programs; promoter; reproductive; research study; response; steroid metabolism; sulfotransferase; tool; trait; transmission process; urinary

项目成果

Carriers of 21-hydroxylase deficiency are not at increased risk for hyperandrogenism.

21-羟化酶缺乏症携带者患高雄激素血症的风险并不增加。

• DOI: 10.1210/jcem.82.2.3759
• 发表时间: 1997
• 期刊: The Journal of clinical endocrinology and metabolism
• 作者: Knochenhauer,ES;Cortet-Rudelli,C;Cunnigham,RD;Conway-Myers,BA;Dewailly,D;Azziz,R
• 通讯作者: Azziz,R

Effect of sex steroids and insulin on dehydroepiandrosterone sulfate production by hepatoma G2 cells.

性类固醇和胰岛素对肝癌 G2 细胞硫酸脱氢表雄酮产生的影响。

• DOI: 10.1016/j.fertnstert.2008.03.049
• 发表时间: 2009
• 期刊: Fertility and sterility
• 影响因子: 6.7
• 作者: Pall,Marita;Nguyen,Margaret;Magoffin,Denis;Azziz,Ricardo
• 通讯作者: Azziz,Ricardo

Nonreplication of the type 5 17beta-hydroxysteroid dehydrogenase gene association with polycystic ovary syndrome.

5 型 17β-羟基类固醇脱氢酶基因的不复制与多囊卵巢综合征相关。

• DOI: 10.1210/jc.2007-1712
• 发表时间: 2008
• 期刊: The Journal of clinical endocrinology and metabolism
• 作者: Goodarzi,MarkO;Jones,MichelleR;Antoine,HeathJ;Pall,Marita;Chen,Yii-DerI;Azziz,Ricardo
• 通讯作者: Azziz,Ricardo

Heritability and the risk of developing androgen excess.

遗传力和雄激素过多的风险。

• DOI: 10.1016/s0960-0760(99)00043-6
• 发表时间: 1999
• 期刊: The Journal of steroid biochemistry and molecular biology
• 作者: Kashar-Miller,M;Azziz,R
• 通讯作者: Azziz,R

Epigenetics in polycystic ovary syndrome: a pilot study of global DNA methylation.

• DOI: 10.1016/j.fertnstert.2009.10.020
• 发表时间: 2010-07
• 期刊: Fertility and sterility
• 影响因子: 6.7
• 作者: Xu N;Azziz R;Goodarzi MO
• 通讯作者: Goodarzi MO