Scaling up the brief alcohol intervention to prevent HIV infection in Vietnam: a cluster randomized, implementation trial
在越南扩大短期酒精干预措施以预防艾滋病毒感染:一项整群随机实施试验
基本信息
- 批准号:10705221
- 负责人:
- 金额:$ 59.05万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-15 至 2027-07-31
- 项目状态:未结题
- 来源:
- 关键词:Active LearningAddressAlcohol consumptionAlcoholsAttitudeBehaviorCharacteristicsClassificationClinicClinicalCognitive TherapyConsentCounselingEffectivenessEnsureGeneral PopulationHIVHIV InfectionsHappinessHealthHealth PersonnelHigh PrevalenceHybridsImpairmentIncidenceInjectionsInterventionMeasuresMediatingMethodsNursesOutcomePathway interactionsPenetrationPersonsPhysiciansPositioning AttributeProfessional counselorRandomizedRandomized, Controlled TrialsReadinessRecommendationReportingResourcesRiskStaff AttitudesTrainingTranslatingUncertaintyVietnamVietnameseViralVirusWorkalcohol abuse therapyalcohol interventionalcohol measurementalcohol misusealcohol use disorderantiretroviral therapyarmbrief alcohol interventioncohortcostdrinkingeffective interventioneffectiveness outcomeexpectationexperienceflexibilityimplementation barriersimplementation interventionimplementation outcomesimplementation strategyimplementation trialimprovedintervention deliverymotivational enhancement therapynoveloptimismorganizational climatepreventrecruitreduced alcohol usescale upsecondary outcomeskillssocialsocial expectationsstandard of caretherapy adherencetooltransmission processtreatment as preventiontrial comparinguptakeviral transmission
项目摘要
PROJECT SUMMARY
More than 25% of people with HIV (PWH) globally report unhealthy alcohol use, defined as a spectrum of use
from risky/hazardous (drinking more than the recommended daily, weekly or per-occasion amounts resulting in
increased risk for health consequences) to alcohol use disorder. PWH with unhealthy alcohol use may not
adhere to their antiretroviral therapy (ART), leading to unsuppressed virus and increasing the potential for HIV
transmission to sexual and injection partners. Interventions that address alcohol use among PWH are needed
to prevent HIV transmission. We previously showed that the brief alcohol intervention (BAI) is effective at
reducing alcohol use and increasing viral suppression in Vietnam. The BAI is ready for scale-up but one barrier
to scale-up is attitudes towards alcohol interventions among clinical staff, especially in regions with normative
unhealthy alcohol use. Addressing clinical staff attitudes may be essential for scale-up. We propose a hybrid
type 3, cluster randomized implementation trial to examine effective strategies to scale up the BAI in ART
clinics in Vietnam. One arm will receive only facilitation for BAI implementation. Facilitation is a flexible strategy
that helps clinics to address common barriers, such as counselor skills, competing priorities, and resource
deficits. In the other arm, in addition to facilitation, clinic staff, irrespective of their own alcohol use, will be
offered the BAI themselves as experiential learning to address their own alcohol-related attitudes and
behaviors. We hypothesize that EBAI, added to facilitation, will increase BAI fidelity, acceptability, and
penetration at the clinic level, and improve viral suppression among PWH with unhealthy alcohol use. Our
specific aims are to: 1) Compare BAI implementation using facilitation (FAC) only to experiential BAI plus
facilitation (EBAI+FAC) in ART clinics in Vietnam; 2) Explore the mechanisms of successful BAI scale up in
both the FAC and EBAI+FAC arms; and 3) Measure the impact of EBAI on clinic staff. ART clinics (n=30)
across Vietnam will be randomized to receive FAC or EBAI+FAC. PWH in the clinics will be screened for
unhealthy alcohol use with the AUDIT-C; if positive, they will be offered the BAI. The primary implementation
outcomes are clinic-level BAI fidelity (primary), with secondary outcomes of acceptability, penetration, and
cost. The effectiveness outcomes are viral suppression (primary) and alcohol use (secondary), measured
among a cohort of PWH recruited in each clinic. Outcomes will be measured at 3 months (implementation
outcomes only) and 12 months (all outcomes). In parallel with the trial, we will use mixed methods to examine
the organizational and clinic staff characteristics that underly successful BAI scale-up. Given the importance of
the clinic staff in the BAI implementation, we will also explore the impact of the BAI on their own alcohol-related
attitudes and use and considering whether they received the BAI themselves or not. This trial will present
critical information for worldwide HIV treatment as prevention efforts, providing strategies for effective scale-up
of the BAI among PWH with unhealthy alcohol use.
项目概要
全球超过 25% 的艾滋病毒感染者 (PWH) 报告有不健康的饮酒行为(定义为饮酒范围)
有风险/有害(饮酒量超过每天、每周或每次推荐的量,导致
增加健康后果的风险)到酒精使用障碍。不健康饮酒的感染者可能不会
坚持抗逆转录病毒治疗 (ART),导致病毒不受抑制并增加感染艾滋病毒的可能性
传播给性伴侣和注射伴侣。需要采取干预措施来解决感染者饮酒问题
以防止艾滋病毒传播。我们之前表明,短暂的酒精干预(BAI)对于以下方面是有效的:
在越南减少饮酒并加强病毒抑制。 BAI 已准备好扩大规模,但存在一个障碍
扩大临床工作人员对酒精干预的态度,尤其是在有规范的地区
不健康的饮酒。解决临床工作人员的态度对于扩大规模可能至关重要。我们提出了一种混合动力
类型 3,整群随机实施试验,检验扩大 ART 中 BAI 的有效策略
越南的诊所。其中一只手臂将仅获得 BAI 实施的便利。便利化是一种灵活的策略
帮助诊所解决常见障碍,例如顾问技能、竞争优先事项和资源
赤字。在另一组中,除了提供便利外,诊所工作人员,无论他们自己是否饮酒,都会
提供 BAI 本身作为体验式学习来解决他们自己与酒精相关的态度
行为。我们假设 EBAI 添加到便利化中,将提高 BAI 的保真度、可接受性和
在临床层面的渗透,并改善不健康饮酒的感染者中的病毒抑制。我们的
具体目标是: 1) 将仅使用便利化 (FAC) 的 BAI 实施与体验式 BAI plus 进行比较
越南 ART 诊所的便利化(EBAI+FAC); 2) 探索 BAI 成功推广的机制
FAC 和 EBAI+FAC 部门; 3) 衡量 EBAI 对诊所工作人员的影响。 ART 诊所 (n=30)
越南各地将随机接受 FAC 或 EBAI+FAC。将对诊所的感染者进行筛查
AUDIT-C 中不健康的饮酒行为;如果呈阳性,他们将获得 BAI。初步实现
结果是临床水平的 BAI 保真度(主要),次要结果是可接受性、渗透性和
成本。测量的有效性结果是病毒抑制(主要)和饮酒(次要)
在每个诊所招募的一组感染者中。结果将在 3 个月后进行衡量(实施
仅结果)和 12 个月(所有结果)。在试验的同时,我们将使用混合方法来检查
BAI 成功扩大规模的组织和诊所人员特征。鉴于重要性
诊所工作人员在实施 BAI 后,我们还将探讨 BAI 对他们自身酒精相关的影响
态度和使用,并考虑他们自己是否收到 BAI。本次试验将呈现
全球艾滋病毒治疗作为预防工作的关键信息,为有效扩大规模提供策略
不健康饮酒的感染者中 BAI 的比例。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
VIVIAN F. GO其他文献
VIVIAN F. GO的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('VIVIAN F. GO', 18)}}的其他基金
A brief alcohol intervention to reduce alcohol use and improve PrEP ouctomes among men who have sex with men: A randomized controlled trial in Vietnam
简短的酒精干预措施可减少男男性行为者的饮酒并改善 PrEP 结果:越南的一项随机对照试验
- 批准号:
10542097 - 财政年份:2022
- 资助金额:
$ 59.05万 - 项目类别:
A brief alcohol intervention to reduce alcohol use and improve PrEP ouctomes among men who have sex with men: A randomized controlled trial in Vietnam
简短的酒精干预措施可减少男男性行为者的饮酒并改善 PrEP 结果:越南的一项随机对照试验
- 批准号:
10705834 - 财政年份:2022
- 资助金额:
$ 59.05万 - 项目类别:
Scaling up the brief alcohol intervention to prevent HIV infection in Vietnam: a cluster randomized, implementation trial
在越南扩大短期酒精干预措施以预防艾滋病毒感染:一项整群随机实施试验
- 批准号:
10542098 - 财政年份:2022
- 资助金额:
$ 59.05万 - 项目类别:
Vietnam Implementation Science Advancement: A Training Program to Improve HIV Prevention and Care
越南实施科学进步:改善艾滋病毒预防和护理的培训计划
- 批准号:
10374946 - 财政年份:2021
- 资助金额:
$ 59.05万 - 项目类别:
Vietnam Implementation Science Advancement: A Training Program to Improve HIV Prevention and Care
越南实施科学进步:改善艾滋病毒预防和护理的培训计划
- 批准号:
10594977 - 财政年份:2021
- 资助金额:
$ 59.05万 - 项目类别:
Vietnam Implementation Science Advancement: A Training Program to Improve HIV Prevention and Care
越南实施科学进步:改善艾滋病毒预防和护理的培训计划
- 批准号:
10244759 - 财政年份:2021
- 资助金额:
$ 59.05万 - 项目类别:
Scaling up HPTN 074: a Cluster Randomized Implementation Trial of an Evidence-based Intervention for Antiretroviral Therapy for PWID in Vietnam
扩大 HPTN 074:越南吸毒者抗逆转录病毒治疗循证干预的整群随机实施试验
- 批准号:
9768997 - 财政年份:2018
- 资助金额:
$ 59.05万 - 项目类别:
Scaling up HPTN 074: a Cluster Randomized Implementation Trial of an Evidence-based Intervention for Antiretroviral Therapy for PWID in Vietnam
扩大 HPTN 074:越南吸毒者抗逆转录病毒治疗循证干预的整群随机实施试验
- 批准号:
10197081 - 财政年份:2018
- 资助金额:
$ 59.05万 - 项目类别:
Scaling up HPTN 074: a Cluster Randomized Implementation Trial of an Evidence-based Intervention for Antiretroviral Therapy for PWID in Vietnam
扩大 HPTN 074:越南吸毒者抗逆转录病毒治疗循证干预的整群随机实施试验
- 批准号:
10430161 - 财政年份:2018
- 资助金额:
$ 59.05万 - 项目类别:
Scaling up HPTN 074: a Cluster Randomized Implementation Trial of an Evidence-based Intervention for Antiretroviral Therapy for PWID in Vietnam
扩大 HPTN 074:越南吸毒者抗逆转录病毒治疗循证干预的整群随机实施试验
- 批准号:
9981750 - 财政年份:2018
- 资助金额:
$ 59.05万 - 项目类别:
相似国自然基金
本体驱动的地址数据空间语义建模与地址匹配方法
- 批准号:41901325
- 批准年份:2019
- 资助金额:22.0 万元
- 项目类别:青年科学基金项目
时空序列驱动的神经形态视觉目标识别算法研究
- 批准号:61906126
- 批准年份:2019
- 资助金额:24.0 万元
- 项目类别:青年科学基金项目
针对内存攻击对象的内存安全防御技术研究
- 批准号:61802432
- 批准年份:2018
- 资助金额:25.0 万元
- 项目类别:青年科学基金项目
大容量固态硬盘地址映射表优化设计与访存优化研究
- 批准号:61802133
- 批准年份:2018
- 资助金额:23.0 万元
- 项目类别:青年科学基金项目
IP地址驱动的多径路由及流量传输控制研究
- 批准号:61872252
- 批准年份:2018
- 资助金额:64.0 万元
- 项目类别:面上项目
相似海外基金
BEATS: Binge drinking Ecological Antecedents with Transdermal alcohol monitoring Study.
BEATS:通过透皮酒精监测研究暴饮暴食的生态前因。
- 批准号:
10827305 - 财政年份:2023
- 资助金额:
$ 59.05万 - 项目类别:
The Development and Evaluation of Enhanced Digital-Chemosensory-Based Olfactory Training for Remote Management of Substance Use Disorders (EDITOR)
用于药物使用障碍远程管理的增强型数字化学感应嗅觉训练的开发和评估(编辑)
- 批准号:
10469912 - 财政年份:2022
- 资助金额:
$ 59.05万 - 项目类别:
Scaling up the brief alcohol intervention to prevent HIV infection in Vietnam: a cluster randomized, implementation trial
在越南扩大短期酒精干预措施以预防艾滋病毒感染:一项整群随机实施试验
- 批准号:
10542098 - 财政年份:2022
- 资助金额:
$ 59.05万 - 项目类别:
Validating an Autonomous Interactive Internet-Based Delivery of an Empirically Supported Cognitive Behavioral Therapy for Comorbidity
验证基于互联网的自主交互式交付经验支持的共病认知行为疗法
- 批准号:
10404961 - 财政年份:2021
- 资助金额:
$ 59.05万 - 项目类别:
Validating an Autonomous Interactive Internet-Based Delivery of an Empirically Supported Cognitive Behavioral Therapy for Comorbidity
验证基于互联网的自主交互式交付经验支持的共病认知行为疗法
- 批准号:
10176912 - 财政年份:2021
- 资助金额:
$ 59.05万 - 项目类别: