Project 1 - Neuroscience Infrastructure at Duke University

项目 1 - 杜克大学神经科学基础设施

• 批准号: 8118838
• 负责人: James O. McNamara
• 金额: $ 4.57万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8118838
• 关键词: Adult; Alleles; Animal Model; Area; Arts; Cancer Center; Center Core Grants; Collaborations; Complex; Development; Disease; Effectiveness; Environment; Equipment; Extramural Activities; Fostering; Funding; Genes; Genetic; Genetically Engineered Mouse; Genie; Genome; Genomics; Human; Improve Access; Individual; Institutes; Ion Channel; Joints; Knock-in Mouse; Knockout Mice; Laboratories; Lead; Medicine; Modeling; Molecular; Mus; National Institute of Neurological Disorders and Stroke; Nervous System Physiology; Nervous system structure; Neurons; Neurosciences; Neurosciences Research; Pathway interactions; Physiological; Population; Predisposition; Proteins; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Resources; Role; Science Policy; Seeds; Services; Susceptibility Gene; Synapses; Technology; Time; Tissues; Transgenic Mice; Universities; Wages; base; cell type; cost; design; gene function; gene replacement; genetic analysis; genetic manipulation; human disease; improved; in vivo; interdisciplinary approach; mouse genome; operation; overexpression; tool; translational neuroscience

In this application for an NINDS Center Core Grant, we seek support for a Neurotransgenic core laboratory at Duke University. This core provides powerful tools for studying the nervous system, where the vast diversity of cell types and synaptic connections require tools that exceed those needed to study simpler, more homogenous tissues. This core will support individual neuroscience research projects by providing necessary resources and performing required services that would be difficult or impractical to provide in individual labs. Institutional commitments of space and seed funds for equipment and salaries have already been obtained and have enabled the creation of this core within the past two years, the understanding being that extramural support would be obtained for their continued support. This core will enrich the effectiveness of ongoing NINDS-supported research at Duke, promote new directions for both basic and translational neuroscience research, and foster a cooperative and interactive research environment through which multidisciplinary approaches to neuroscience problems and joint research efforts will be stimulated. Moreover, this provides a cost-effective way for investigators to exploit cutting-edge, specialized technologies that would be difficult to setup or justify for an individual laboratory. This core has been developed in partnership with other administrative units within Duke University including the Cancer Center. This core will be utilized by neuroscientists residing in multiple departments, thereby fostering a cooperative and interactive research environment. This core represents a substantial infrastructure support for genetic analysis in support of the neurosciences.

在此申请Ninds Center Core Grant中，我们寻求支持神经转基因核心 杜克大学实验室。该核心提供了研究神经系统的强大工具， 在大量的细胞类型和突触连接需要超过所需的工具的地方 研究更简单，更同质的组织。该核心将支持单个神经科学研究 通过提供必要的资源和执行所需服务的项目，这将很困难或 不切实际地提供在单个实验室中。空间和种子资金的机构承诺 设备和薪水已经获得，并使该核心在内部创建 过去两年，理解是将获得壁外支持 持续支持。该核心将丰富正在进行的Ninds支持研究的有效性 杜克大学，促进基本和转化神经科学研究的新方向，并促进 合作和互动研究环境，多学科的方法 神经科学问题和联合研究工作将受到刺激。此外，这提供了 调查人员利用尖端，专业技术的成本效益的方式 很难为个别实验室设置或合理。该核心已与 杜克大学内的其他行政部门，包括癌症中心。这个核心将是 由居住在多个部门的神经科学家使用，从而促进了合作社和 互动研究环境。该核心代表了对遗传的大量基础设施支持 支持神经科学的分析。