Advanced PET System Dedicated to Breast Cancer Imaging

专用于乳腺癌成像的先进 PET 系统

• 批准号: 7919118
• 负责人: CRAIG S LEVIN
• 金额: $ 41.37万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7919118
• 关键词: 3-Dimensional; Address; Algorithms; Area; Axillary lymph node group; Breast; Caliber; Calibration; Chest; Clinic; Clinical; Clinical Research; Collection; Communities; Cost Control; Coupled; Data; Detection; Development; Diagnosis; Electronics; Enhancing Lesion; Ensure; Event; Funding; Future; Goals; Grant; Head; Hospitals; Image; Imagery; Intervention; LSO crystal; Length; Lesion; Light; Lutetium; Magnetic Resonance Imaging; Malignant Neoplasms; Measurement; Measures; Modality; Molecular; Monitor; Noise; Performance; Peripheral; Photons; Polishes; Positioning Attribute; Positron-Emission Tomography; Process; Production; Property; Radiology Specialty; Research; Research Personnel; Resolution; Role; Scanning; Semiconductors; Sensitivity and Specificity; Signal Transduction; Source; Specificity; Staging; Structure; Surface; System; Technology; Testing; Thick; Time; Tracer; Translating; Tube; United States National Institutes of Health; Variant; Width; Work; base; breast lesion; cancer imaging; cost; data acquisition; design; detector; flexibility; image reconstruction; improved; innovation; malignant breast neoplasm; novel; photomultiplier; programs; quantum; sensor; software systems; uptake

DESCRIPTION (provided by applicant): We propose to build an advanced positron emission tomography (PET) system dedicated to breast cancer imaging. The system uses a novel position sensitive photon detector concept that has been developed under grant R21 CA098691 that we propose to translate into the clinic. This new sensor will help to push the performance limits of PET for cancer imaging. The design uses scintillation crystals coupled in an innovative manner to new, highly compact semiconductor photodetector arrays. This development allows us to achieve 1 mm spatial resolution with direct photon interaction depth measurement, high 511 keV photon detection efficiency, and a scintillation detector configuration that promotes >95% scintillation light collection efficiency for exceptional energy and coincident time resolution. Although this new photon sensor concept could in principle be utilized in any high resolution PET cancer imaging application, we are focusing on breast cancer because there is particular potential for high impact. PET has shown promise for breast cancer imaging, but has not been incorporated into standard practice due to inadequate breast cancer specificity and sensitivity, relatively long scan times, and high cost. If successful, our developments will have impact on increasing the role of PET in breast cancer management by addressing all of these issues. The proposed system will have 1 mm reconstructed spatial resolution in order to better visualize <2.5 mm structures of high focal uptake as indication of early breast cancer. This camera will use 2 cm thick, closely packed crystals, and close proximity breast imaging for up to 15% coincidence efficiency to help realize the desired spatial resolution proposed and rapidly (in 10 seconds) generate images. PET breast imaging poses particular challenges due to background activity in the thorax producing high random and Compton scatter coincident photon rates that result in lower lesion to background contrast. The excellent energy and temporal resolutions and flexible orientation achieved with the new design will help to reduce background photon scatter and random effects on lesion contrast. This system will also help breast cancer researchers to evaluate more specific breast cancer tracers and monitor potential treatments. For this five-year project we will integrate the novel detector modules into a gantry, develop a data acquisition system, implement data correction, calibration, and image reconstruction algorithms, and test the system with point source measurements.

描述（由申请人提供）：我们建议建立一个用于乳腺癌成像的高级正电子发射断层扫描（PET）系统。该系统使用了一种新型位置敏感的光子检测器概念，该概念已在赠款R21 CA098691下开发，我们建议将其转化为诊所。该新传感器将有助于推动PET的性能限制进行癌症成像。该设计使用闪烁晶体以创新的方式与新的高度紧凑的半导体光电探测器阵列结合在一起。这种开发使我们能够实现1 mM的空间分辨率，具有直接光子相互作用深度测量，高511 keV光子检测效率以及闪烁检测器构型，可促进> 95％的闪烁光收集效率，以促进出色的能量和一致的时间分辨率。尽管这种新的光子传感器概念原则上可以在任何高分辨率的PET癌成像应用中使用，但我们将重点放在乳腺癌上，因为有可能产生高影响力。 PET显示出对乳腺癌成像的希望，但由于乳腺癌的特异性不足和敏感性，相对较长的扫描时间和高成本，因此尚未将其纳入标准实践中。如果成功，我们的发展将通过解决所有这些问题来影响宠物在乳腺癌管理中的作用。所提出的系统将具有1 mM重建的空间分辨率，以便更好地将高局灶性摄取的<2.5 mM结构可视化为早期乳腺癌的指示。该相机将使用2厘米厚，紧密堆积的晶体，并近距离乳房成像​​，以最多15％的巧合效率，以帮助实现所需的空间分辨率，并迅速（在10秒内）生成图像。 PET乳房成像由于胸部的背景活动而构成了特定的挑战，产生了高随机和康普顿散射的光子速率，从而导致病变降低到背景对比度。通过新设计实现的出色能量和时间分辨率以及灵活的方向将有助于减少背景光子散射以及对病变对比的随机影响。该系统还将帮助乳腺癌研究人员评估更具体的乳腺癌示踪剂并监测潜在的治疗方法。对于这个五年的项目，我们将将新颖的检测器模块整合到龙门，开发数据采集系统，实现数据校正，校准和图像重建算法，并通过点源测量测试系统。