SPF BREEDING COLONIES AT THE YERKES NPRC: AIDS, HIV VACCINE DVMT

YERKES NPRC 的 SPF 繁殖群：艾滋病、HIV 疫苗 DVMT

• 批准号: 7961165
• 负责人: JAMES GIBSON ELSE
• 金额: $ 28.7万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7961165
• 关键词: Acquired Immunodeficiency Syndrome; Animals; Award; Breeding; Computer Retrieval of Information on Scientific Projects Database; Ensure; Fees; Funding; Goals; Grant; HIV vaccine; Human Resources; Income; Institution; Macaca; Macaca mulatta; Methods; Monkeys; National Center for Research Resources; Phase; Primates; Procedures; Reproduction; Research; Research Personnel; Research Subjects; Resources; Safety; Screening procedure; Source; Specific Pathogen Frees; Testing; U-Series Cooperative Agreements; United States National Institutes of Health; base; experience; germ free condition; interest; juvenile animal; meetings; programs

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. DESCRIPTION (provided by applicant): The central objective of this project is to breed rhesus macaques that are specific pathogen free (SPF- as defined by NCRR in RFA RR-G2-005), MHC typed and genetically characterized to provide research subjects to NIH supported investigators for AIDS related research. This objective will be achieved at the YNPRC National Primate Research Center (YNPRC) utilizing an existing colony of 745 SPF macaque monkeys (produced and maintained since 2002 with the support of NCRR Cooperative Agreement U24 RR 018109) and employing skilled and experienced personnel and proven methods and procedures that have been highly successful to date. The existing SPF rhesus macaque colony will be managed to optimize reproduction, both to provide subjects to AIDS investigators, and to increase its total size via breeding. Additionally, during the first two years of this project phase, we will continue recruitment of young animals from YNPRC non-SPF breeding colonies via appropriate testing and separation. The goal is to ensure the availability of SPF subjects to meet the requirements of AIDS investigators, both Emory based and from other institutions regionally and nationally; this is an objective we have achieved very successfully in the past award period (2002 to 2007). The overall YNPRC goal is to transition to an entirely SPF Field Station based rhesus colony by 2013, progressively replacing the non-SPF rhesus macaques in the colony with SPF animals. This goal, although vital to the interests of the Center (and NCRR) in both scientific and safety terms, goes beyond the scope of the present proposal. Thus, we seek here support for a fixed colony of 500 SPF monkeys although we describe a program that includes 745 animals at the outset and that we intend to increase substantially in the proposed award period. The proposed colony of 500 to be supported by this mechanism is level with the effort in the initial award period and, with supplemental animals from our screening program, is sufficient to meet the requirements of our AIDS research portfolio. The SPF animals in excess of the 500 will be supported from program income associated with the base grant (e.g. per diem and use fees) from NCRR to the YNPRC (P51 - RR00165). As the SPF colony grows the conventional colony will be reduced in size, with the goal of achieving a 100% SPF rhesus breeding colony by 2013.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 描述（由申请人提供）：该项目的核心目的是繁殖特定病原体的猕猴（由NCRR在RFA RR-G2-005中定义的SPF-），MHC键入且遗传学特征，旨在为NIH支持的研究对AIDS相关研究的研究对象提供研究对象。该目标将在YNPRC国家灵长类动物研究中心（YNPRC）中实现，该殖民地现有的殖民地为745 SPF猕猴（自2002年以来生产和维护，并在NCRR合作协议U24 RR 018109的支持下），并雇用了熟练的，经验丰富的人员和经验丰富的人员和经验丰富的方法和迄今已取得了非常成功的方法。现有的SPF恒河猕猴菌落将被设法优化繁殖，既可以为AIDS研究人员提供受试者，又可以通过育种来增加其总尺寸。此外，在此项目阶段的前两年中，我们将通过适当的测试和分离继续招募YNPRC非SPF繁殖菌落的年轻动物。目的是确保SPF受试者的可用性满足基于Emory的AIDS调查人员的要求，以及来自地区和全国其他机构的要求；这是我们在过去的奖项期（2002年至2007年）中成功实现的目标。 YNPRC的总体目标是到2013年过渡到完全基于SPF的恒河类殖民地，并逐渐用SPF动物代替了菌落中的非SPF恒河猕猴。该目标虽然对中心（和NCRR）的利益至关重要，但在科学和安全方面都超出了本提议的范围。因此，我们在这里寻求支持500个SPF猴子的固定菌落，尽管我们描述了一项包括745只动物的程序，并打算在拟议的奖励期间大幅增加。该机制支持的500个殖民地在初始奖励期间的努力水平与我们的筛查计划中的补充动物相满足，足以满足我们的艾滋病研究组合的要求。超过500的SPF动物将得到与基本赠款相关的计划收入（例如，从NCRR到YNPRC）到YNPRC（p51 -rr00165）。随着SPF殖民地的生长，常规菌落的大小将减小，其目标是到2013年达到100％的SPF恒河猴繁殖菌落。