Maturation processes of hippocampal coding in developing rats

发育中大鼠海马编码的成熟过程

基本信息

批准号：
7897195
负责人：
Pierre Pascal Lenck-Santini
金额：
$ 20.5万
依托单位：
DARTMOUTH COLLEGE
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-04-01 至 2012-02-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7897195
关键词：
ARHGEF5 gene Address Adult Adverse effects Affect Age Agreement Animals Behavior Behavioral Cells Characteristics Childhood Childhood Neurological Disorder Clinical Code Cognition Cues Data Development Developmental Process Dissociation Economics Electrodes Electroencephalography Environment Environmental Risk Factor Episodic memory Event Evolution Fire - disasters Genetic Goals Growth Hippocampus (Brain)Human Human Development Implant Individual Intervention Knowledge Learning Lesion Life Literature Location Maps Memory Modeling Neurologic Neurons Performance Phase Physiological Play Process Property Pyramidal Cells Quality of life Rattus Research Rodent Rodent Model Role Seizures Sensory Shapes Signal Transduction Spatial Behavior Staging Structure System Testing Theta Rhythm Time Visual aged base cognitive function critical period developmental disease information processing nervous system disorder postnatal public health relevance receptive field research study social theories

项目摘要

DESCRIPTION (provided by applicant): The maturation of learning and memory abilities during childhood is critical for the development of the individual. Before trying to characterize how neurological disorders affect this process, we aim to understand the normal mechanisms underlying the maturation of the function of the hippocampus, a structure playing a major role in learning and memory. Particularly, our goal is to determine how the ability of this structure to encode, store and retrieve information develops in immature rats. To do so, we will study the discharge of hippocampal neurons in developing, freely moving rats. These neurons, called place cells, are active only when the rat enters a specific region of the environment, the cell's place field. Place cells are believed to be the neuronal substrate of spatial memory. In a first Aim, we will evaluate place cell signal development in rats aged from postnatal day (P)18 to P60. Three experiments will investigate different aspects of place cell discharge. In the first experiment, the ontogeny of place cell signal quality and stability at short and long term will be analyzed. In the second experiment, we will determine how the sensory properties of place cells develop with age. The third experiment will focus on the relationships between place cell discharge and the hippocampal EEG oscillation called theta rhythm. This relationship, an example of temporal coding, is believed to be critical for organizing and processing information. Public Health Relevance: To determine the role of these maturational steps in learning and memory, we will study, in the second aim the relationships between place cell firing and memory performance in a spatial task. Place cells will be recorded in immature rats while they perform a place avoidance task. The eventuality of dissociation between spatial behavior and place cell firing will challenge our present understanding of hippocampal function. Our overall goal is to determine the critical phases of place cell development. This knowledge will serve as a reference for investigating how neurological disorders affect learning and memory systems. We believe that it will help define appropriate timing for clinical intervention in developmental disorders

描述（由申请人提供）：儿童期间学习和记忆能力的成熟对于个人的发展至关重要。在试图表征神经系统疾病如何影响这一过程之前，我们旨在了解海马功能成熟的正常机制，这种结构在学习和记忆中起着重要作用。特别是，我们的目标是确定该结构在未成熟大鼠中的编码，存储和检索信息的能力如何发展。为此，我们将研究在发育自由移动的大鼠中的海马神经元的排出。这些神经元（称为位置细胞）仅在大鼠进入环境（细胞的位置场）的特定区域时才活跃。据信，位置细胞是空间记忆的神经元底物。在第一个目标中，我们将评估从产后（p）18至P60的老鼠的位置细胞信号发育。三个实验将研究放电的位置细胞放电的不同方面。在第一个实验中，将分析位置细胞信号质量和稳定性在短期和长期的稳定性。在第二个实验中，我们将确定位置细胞的感觉特性如何随着年龄的增长而发展。第三个实验将集中于位置细胞放电和称为theta节奏的海马脑电图之间的关系。这种关系是时间编码的一个例子，被认为对于组织和处理信息至关重要。公共卫生相关性：为了确定这些成熟步骤在学习和记忆中的作用，我们将在第二个目标中研究空间任务中的位置细胞点火与记忆性能之间的关系。在执行避开位置任务的同时，将在未成熟的大鼠中记录位置细胞。空间行为与位置解散之间解离的最终性将挑战我们目前对海马功能的理解。我们的总体目标是确定位置细胞开发的关键阶段。这些知识将作为研究神经系统疾病如何影响学习和记忆系统的参考。我们认为，它将有助于定义适当的时间安排发育障碍的临床干预