Maturation processes of hippocampal coding in developing rats

发育中大鼠海马编码的成熟过程

基本信息

批准号：
7897195
负责人：
Pierre Pascal Lenck-Santini
金额：
$ 20.5万
依托单位：
DARTMOUTH COLLEGE
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-04-01 至 2012-02-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7897195
关键词：
ARHGEF5 gene Address Adult Adverse effects Affect Age Agreement Animals Behavior Behavioral Cells Characteristics Childhood Childhood Neurological Disorder Clinical Code Cognition Cues Data Development Developmental Process Dissociation Economics Electrodes Electroencephalography Environment Environmental Risk Factor Episodic memory Event Evolution Fire - disasters Genetic Goals Growth Hippocampus (Brain)Human Human Development Implant Individual Intervention Knowledge Learning Lesion Life Literature Location Maps Memory Modeling Neurologic Neurons Performance Phase Physiological Play Process Property Pyramidal Cells Quality of life Rattus Research Rodent Rodent Model Role Seizures Sensory Shapes Signal Transduction Spatial Behavior Staging Structure System Testing Theta Rhythm Time Visual aged base cognitive function critical period developmental disease information processing nervous system disorder postnatal public health relevance receptive field research study social theories

项目摘要

DESCRIPTION (provided by applicant): The maturation of learning and memory abilities during childhood is critical for the development of the individual. Before trying to characterize how neurological disorders affect this process, we aim to understand the normal mechanisms underlying the maturation of the function of the hippocampus, a structure playing a major role in learning and memory. Particularly, our goal is to determine how the ability of this structure to encode, store and retrieve information develops in immature rats. To do so, we will study the discharge of hippocampal neurons in developing, freely moving rats. These neurons, called place cells, are active only when the rat enters a specific region of the environment, the cell's place field. Place cells are believed to be the neuronal substrate of spatial memory. In a first Aim, we will evaluate place cell signal development in rats aged from postnatal day (P)18 to P60. Three experiments will investigate different aspects of place cell discharge. In the first experiment, the ontogeny of place cell signal quality and stability at short and long term will be analyzed. In the second experiment, we will determine how the sensory properties of place cells develop with age. The third experiment will focus on the relationships between place cell discharge and the hippocampal EEG oscillation called theta rhythm. This relationship, an example of temporal coding, is believed to be critical for organizing and processing information. Public Health Relevance: To determine the role of these maturational steps in learning and memory, we will study, in the second aim the relationships between place cell firing and memory performance in a spatial task. Place cells will be recorded in immature rats while they perform a place avoidance task. The eventuality of dissociation between spatial behavior and place cell firing will challenge our present understanding of hippocampal function. Our overall goal is to determine the critical phases of place cell development. This knowledge will serve as a reference for investigating how neurological disorders affect learning and memory systems. We believe that it will help define appropriate timing for clinical intervention in developmental disorders

描述（由申请人提供）：童年时期学习和记忆能力的成熟对于个人的发展至关重要。在尝试描述神经系统疾病如何影响这一过程之前，我们的目标是了解海马体功能成熟的正常机制，海马体是一种在学习和记忆中发挥重要作用的结构。特别是，我们的目标是确定这种结构编码、存储和检索信息的能力如何在未成熟的大鼠中发展。为此，我们将研究发育中、自由活动的大鼠海马神经元的放电。这些神经元称为位置细胞，仅当大鼠进入环境的特定区域（即细胞的位置场）时才会活跃。位置细胞被认为是空间记忆的神经元基质。第一个目标是评估出生后 (P)18 至 P60 龄大鼠的位置细胞信号发育。三个实验将研究地方电池放电的不同方面。在第一个实验中，将分析短期和长期的位置细胞信号质量和稳定性的个体发育。在第二个实验中，我们将确定位置细胞的感觉特性如何随着年龄的增长而发展。第三个实验将重点关注位置细胞放电与海马脑电图振荡（称为 θ 节律）之间的关系。这种关系（时间编码的一个例子）被认为对于组织和处理信息至关重要。公共健康相关性：为了确定这些成熟步骤在学习和记忆中的作用，我们将在第二个目标中研究空间任务中位置细胞放电和记忆表现之间的关系。当未成熟大鼠执行位置回避任务时，将记录位置细胞。空间行为和位置细胞放电之间的分离的可能性将挑战我们目前对海马功能的理解。我们的总体目标是确定位置细胞发育的关键阶段。这些知识将为研究神经系统疾病如何影响学习和记忆系统提供参考。我们相信这将有助于确定发育障碍临床干预的适当时机