Physical Activity in Overweight Girls: Implications for Reversing Risk Factors fo

超重女孩的体力活动：对扭转风险因素的影响

基本信息

批准号：
7990028
负责人：
SoJung Lee
金额：
$ 21.98万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-07-15 至 2012-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7990028
关键词：
Adolescent Adult Aerobic Aerobic Exercise Affect American Antiatherogenic Arts Attention Award Biological Markers Body Composition Body Weight Body Weight Changes Body fat Caloric Restriction Cardiovascular Diseases Cardiovascular system Central obesity Child Childhood Clinical Clinical Trials Comorbidity Controlled Study Development Diabetes Mellitus Diet Epidemic Equilibrium Exercise Faculty Fatty acid glycerol esters Funding Gender Glucose Guidelines Health Health Benefit High Prevalence Hormones Hyperglycemia Inflammatory Insulin Resistance Interleukin-6 Intervention Investigation Laboratories Lipids Liver Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Measures Mediating Metabolic Metabolic syndrome Methodology Modality Monitor National Health and Nutrition Examination Survey Non-Insulin-Dependent Diabetes Mellitus Obesity Outcome Overweight Physical activity Physiologic pulse Physiological Plasminogen Activator Inhibitor 1 Play Prediabetes syndrome Premature aging syndrome Prevalence Prevention Protons Public Health Race Randomized Randomized Controlled Trials Recruitment Activity Research Resistance Risk Risk Factors Role Secure Skeletal Muscle Sleep Apnea Syndromes Techniques Testing Therapeutic Time Training Triglycerides Tumor Necrosis Factor-alpha Visceral Weight Woman Youth abdominal fat adiponectin age group atherogenesis boys clinically significant combat density diabetes risk evidence base fitness girls glucose tolerance group intervention improved in vivo indexing inflammatory marker insulin secretion insulin sensitivity men muscle form obesity in children public health relevance response sedentary strength training subcutaneous treatment strategy

项目摘要

DESCRIPTION (provided by applicant): Childhood obesity is a leading public health concern because overweight youth suffer from co-morbidities such as insulin resistance, type 2 diabetes mellitus (T2DM), metabolic syndrome and cardiovascular disease, conditions once considered unique to adults. Although the causes of childhood obesity are not clear, decreased physical activity (PA) is a major factor. In adults, it is well established that regular PA (>150 min/wk) or 30 min/day of PA for 5-7 days/wk is associated with significant reductions in adiposity and prevention of T2DM. However, the potential benefits of this level of PA alone (without calorie restriction) on abdominal obesity, ectopic fat and risk factors for T2DM are unclear in overweight girls. Therefore, we will examine the effects of regular exercise without calorie restriction in overweight girls on: 1) in vivo insulin sensitivity and secretion and risk of T2DM using the clamp technique; 2) total and abdominal adiposity using whole body magnetic resonance imaging; 3) ectopic fat in the liver and skeletal muscle using 1H-magnetic resonance spectroscopy. More specifically, we will compare the effects of different exercise modalities (aerobic exercise versus resistance exercise) on these health markers, and explore the potential mechanisms by which regular exercise mediates improvements in health risks associated with T2DM. We will recruit 42 sedentary overweight black and white girls, and randomly assign them to one of three 3-month intervention groups: aerobic training (180 min per week), resistance training (180 min per week), or no-exercise control. We believe that the results of this study will be of significance for the development of evidence-based public health and clinical guidelines in our efforts to combat the current epidemic of childhood obesity. PUBLIC HEALTH RELEVANCE: We will examine the effect of a 3-month exercise training (aerobic exercise versus resistance exercise) without dieting on obesity reduction, and improving fitness, body composition and risk of type 2 diabetes in overweight black and white girls.

描述（由申请人提供）：儿童肥胖是一个领先的公共卫生问题，因为超重的青年患有胰岛素抵抗，2型糖尿病（T2DM），代谢综合征和心血管疾病等合并症，曾经被认为是成人独有的疾病。尽管儿童肥胖的原因尚不清楚，但体育活动减少（PA）是一个主要因素。在成年人中，众所周知，普通的PA（> 150分钟/周）或PA的30分钟/天持续5-7天/周与T2DM的肥胖和预防的显着降低有关。但是，仅此水平的PA（不含卡路里限制）对腹部肥胖，异位脂肪和T2DM的危险因素的潜在好处在超重的女孩中尚不清楚。因此，我们将使用夹具技术来检查超重女孩对超重女孩的定期运动的影响：1）使用夹具技术在体内胰岛素敏感性，分泌和T2DM的风险； 2）使用全身磁共振成像的总和腹部肥胖； 3）使用1H磁共振光谱法中肝脏和骨骼肌的异位脂肪。更具体地说，我们将比较不同运动方式（有氧运动与抵抗运动）对这些健康标记物的影响，并探讨常规运动介导与T2DM相关的健康风险改善的潜在机制。我们将招募42个久坐的超重黑白女孩，并将其随机分配给三个三个月的干预组之一：有氧训练（每周180分钟），阻力训练（每周180分钟）或无运动控制。我们认为，这项研究的结果对于制定基于证据的公共卫生和临床指南具有重要意义，我们努力应对当前的儿童肥胖症流行。公共卫生相关性：我们将研究3个月的运动训练（有氧运动与抵抗运动）的影响，而无需节食肥胖，改善超重黑白女孩中2型糖尿病的健身，身体组成和风险。