ANNOTATION OF PROTEIN FUNCTION BY LIGAND DESCRIPTORS

通过配体描述符对蛋白质功能进行注释

基本信息

批准号：
8170534
负责人：
Brian K Shoichet
金额：
$ 0.71万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-07-01 至 2011-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8170534
关键词：
Bioinformatics Biology Cells Characteristics Chemicals Chemistry Chromosome Mapping Computer Retrieval of Information on Scientific Projects Database Descriptor Fingerprint Funding Grant Institution Ligands Orphan Protein Fingerprints Proteins Reagent Research Research Personnel Resources Role Source Structure United States National Institutes of Health base protein function receptor structural genomics tool

Bioinformatics Biology Cells Characteristics Chemicals Chemistry Chromosome Mapping Computer Retrieval of Information on Scientific Projects Database Descriptor Fingerprint Funding Grant Institution Ligands Orphan Protein Fingerprints Proteins Reagent Research Research Personnel Resources Role Source Structure United States National Institutes of Health base protein function receptor structural genomics tool

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项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A key problem in biology is assigning function to proteins of known sequence, sometimes even known structures, but unknown activity. Examples include efforts to de-orphan receptors, determine targets in cell-based (functional) screens, and structural genomics. Much effort has been focused on bioinformatics tools, but a possible role for chemical information has largely been ignored. Many proteins recognize characteristic sets of organic molecules (ligands), either in their normal function or as reagents that interrupt this function. We propose to "fingerprint" proteins using their ligands. Based on the similarity of this fingerprint to those of other proteins, it should be possible to create ligand chemistry-based linkage maps and to infer protein function.

该副本是利用众多研究子项目之一由NIH/NCRR资助的中心赠款提供的资源。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构是对于中心，这不一定是调查员的机构。生物学的关键问题是将功能分配给已知的蛋白质序列，有时甚至是已知的结构，但活动未知。例子包括努力去孔子受体，确定目标基于细胞的（功能）筛选和结构基因组学。努力一直专注于生物信息学工具，但可能是化学信息在很大程度上被忽略了。许多蛋白质识别有机分子（配体）的特征集，要么在其中正常功能或作为中断此功能的试剂。我们建议使用其配体“指纹”蛋白质。基于这种指纹与其他蛋白质的相似性，应该有可能创建基于配体化学的链接图并推断蛋白质功能。