Enhanced Surveillance-Newly Vaccine Preventable Diseases

加强监测——新疫苗可预防疾病

• 批准号: 7915042
• 负责人: PETER G SZILAGYI
• 金额: $ 43.68万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-30 至 2010-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7915042
• 关键词: Enhanced; Surveillance; Newly; Vaccine; Preventable

Understanding the total health burden of vaccine-preventable diseases (VPD), and the impact of vaccine policies on health care provision is critical to developing vaccine strategies. Our Rochester New Vaccine Surveillance Network (NVSN) site (a founding NVSN member), has demonstrated a large inpatient burden of VPD using population-based studies with molecular viral diagnosis. We propose to enhance our NSVN by measuring and comparing the total burden of VPDs in hospital, Emergency Department (ED), & outpatient care settings, and by studying the healthcare impact of current & new vaccine policies. Seven projects in 4 major areas are proposed, to determine the: A.) population-based burden in children ages 0<5y of acute respiratory infection from influenza (A,B), RSV (A,B), parainfluenza viruses (1,2,3), & human metapneumo- virus in the area's only 2 pediatric hospitals (300 samples/y), corresponding 2 EDs (300 sampies/y), & 6 outpatient sites (400samples/y); B.) changes in healthcare from the introduction of new vaccines/policies on both vaccine practices/vaccine coverage for influenza & pneumococcal (PCV7) vaccines and on community disease burden (e.g. otitis media after PCV7) (by performing 4000 chart reviews in 60 practices [>85% of the population of 2-5y-olds], and by analyzing a local insurance dataset [n=140,000, >70% of population] and national datasets); C.) influenza vaccine effectiveness in preventing hospital, ED, & outpatient visits (case- cohort studies-cases from all 3 healthcare settings, controls from community, and strata of all children ages 6-23m & high risk children ages 2-5y); D.) potential burden of rotavirus disease to prepare for population- based laboratory surveillance for soon anticipated new vaccines (dataset analyses and chart reviews). Our 5y-old NVSN has experienced personnel, accurate laboratory and surveillance techniques, and the ability to respond quickly to new needs. This proposal will provide information integral to developing sound polices consistent with national goals to preventing VPD in children.

了解可预防疾病（VPD）的总健康负担以及疫苗的影响 医疗保健提供政策对于制定疫苗策略至关重要。我们的罗切斯特新疫苗 监视网络（NVSN）站点（成立的NVSN成员）表现出很大的住院负担 VPD使用基于人群的分子病毒诊断研究。我们建议通过 衡量和比较医院，急诊科（ED）和门诊的VPD的总负担 护理环境，以及研究当前和新疫苗政策的医疗保健影响。 4个项目中的七个项目 提出了主要领域，以确定：A。A.）急性0 <5y的儿童基于人群的负担 流感（A，B），RSV（A，B），Parainfluenza病毒（1,2,3）和人类Metapneumo-受到流感（A，B），RSV（A，B）的呼吸道感染 该地区只有2家儿科医院（300个样本/y），相应2 eds（300 sampies/y），＆6 门诊站点（400个样本/y）； B.）从引入新的疫苗/政策的医疗保健变化 流感和肺炎疫苗（PCV7）疫苗的疫苗实践/疫苗覆盖范围和社区 疾病负担（例如PCV7之后的中耳炎）（通过在60种实践中进行4000个图表评论[> 85％ 2-5岁的人口]，并通过分析当地保险数据集[n = 140,000，> 70％的人口]和 国家数据集）； C.）流感疫苗在预防医院，ED和门诊就诊（病例 - 来自所有3种医疗保健环境，社区控制和所有儿童年龄阶层的同类研究案例 6-23m＆高风险儿童2-5岁）; D.）轮状病毒疾病的潜在负担为人口做准备 - 基于实验室监视，可预测新疫苗（数据集分析和图表评估）。我们的 5岁的NVSN具有经验丰富的人员，准确的实验室和监视技术，以及具有的能力 快速响应新需求。该提案将为制定声音政策提供不可或缺的信息 与防止儿童VPD的国家目标一致。