SMALL MOLECULES REGULATING PROTEIN-PROTEIN INTERACTIONS IN CANCER

调节癌症中蛋白质-蛋白质相互作用的小分子

• 批准号: 7955284
• 负责人: PETER K VOGT
• 金额: $ 0.32万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7955284
• 关键词: 1-Phosphatidylinositol 3-Kinase; Affect; Area; Biomedical Computing; Characteristics; Chemicals; Collaborations; Computer Retrieval of Information on Scientific Projects Database; Funding; Goals; Grant; Institution; Malignant Neoplasms; Oncogenes; Pathway interactions; Regulation; Research; Research Personnel; Resources; Site; Source; Therapeutic; United States National Institutes of Health; drug development; inhibitor/antagonist; programs; protein protein interaction; small molecule

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. (A) Objectives. Chemical modulation and inhibition of oncogene regulation and expression is a promising therapeutic approach to the treatment of many cancers. To advance this approach, our goal is the identification, optimization and characterization of small molecule inhibitors and stabilizers of protein-protein interactions affecting the Myc network and the PI 3-kinase (PI3K) pathway. Protein-protein interactions remain challenging targets for small molecules; progress in this area will open new opportunities for drug development. This collaboration will rely upon several advances in the AutoDock suite of programs that enable the discovery of drugable sites to modulate protein-protein interactions, and which factor in dynamic characteristics of these sites.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 （a）目标。化学调节和对癌基因调节和表达的抑制是许多癌症治疗的有前途的治疗方法。为了推进这种方法，我们的目标是影响MYC网络和PI 3-激酶（PI3K）途径的蛋白质蛋白相互作用的小分子抑制剂和稳定剂的鉴定，优化和表征。 蛋白质 - 蛋白质相互作用仍然是小分子的挑战靶标。该领域的进展将为药物开发开辟新的机会。这项合作将依赖于Autodock套件的几个进步，这些程序可以发现可吸毒位点调节蛋白质 - 蛋白质相互作用，以及这些位点动态特征的因素。