Muscle Weakness and Post-Traumatic Knee OA

肌肉无力和创伤后膝关节骨关节炎

• 批准号: 7924180
• 负责人: TERESE L CHMIELEWSKI
• 金额: $ 10.77万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-30 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7924180
• 关键词: Aftercare; Arts; Biochemical; Biological Assay; Biological Markers; Biomechanics; C-terminal; Cartilage; Clinical; Collagen Type II; Conduct Clinical Trials; Defect; Degenerative polyarthritis; Development Plans; Doctor of Philosophy; Electric Stimulation; Enrollment; Environment; Enzymes; Exercise; Faculty; Florida; Goals; Humulus; Inflammation; Inflammatory; Intervention; Investigation; K-Series Research Career Programs; Kinesiology; Knee; Knee Injuries; Knee Osteoarthritis; Leg; Link; Lower Extremity; Magnetic Resonance Imaging; Master' s Degree; Measures; Mentored Research Scientist Development Award; Mentors; Mentorship; Morphology; Muscle; Muscle Weakness; Outcome Measure; Patient Self-Report; Persons; Physical therapy; Questionnaires; Randomized; Reaction; Rehabilitation Research; Rehabilitation therapy; Research; Research Personnel; Risk; Side; Structure; Synovial Fluid; Testing; Training; Tumor Necrosis Factor-alpha; Universities; Work; articular cartilage; career; career development; crosslink; cytokine; design; experience; functional outcomes; human TNF protein; indexing; injured; meetings; multidisciplinary; neuromuscular; professor; programs; quadriceps muscle; skills; symposium; urinary

DESCRIPTION (provided by the applicant): The applicant is an Assistant Professor in the University Of Florida Department Of Physical Therapy. She has a Master's degree in Physical Therapy and a Ph.D. in Biomechanics and Movement Sciences. Her goal is to become an independent investigator focused on designing and implementing multidisciplinary clinical and translational investigations to maximize functional outcome and reduce the risk for post-traumatic osteoarthritis (OA) in persons with knee injury. Through this K01 award, the applicant will gain skills in conducting clinical trials, assessing articular cartilage morphology with magnetic resonance imaging (MRI), and performing biochemical analysis of articular cartilage and inflammation biomarkers to become uniquely cross-trained and able to undertake a comprehensive approach to studying knee rehabilitation. Her co-mentors, Dr. Vandenborne and Dr. Leeuwenburgh, will help her transition from junior faculty to independent investigator through rigorous mentorship and practical training, didactic course work, and participation in seminars and conferences. The Primary Aim of the research plan is to determine the effect of intensive quadriceps strengthening on functional outcome and articular cartilage structure after meniscectomy. The Secondary Aim is to examine the association of post-meniscectomy quadriceps strength deficits with lower extremity loading symmetry and the extent of knee inflammation. After baseline testing, 54 subjects with a meniscectomy will be randomly assigned to a 6-week standard rehabilitation program or standard rehabilitation augmented with intensive quadriceps strengthening (high-intensity neuromuscular electrical stimulation and eccentric exercise). Subjects will be re-assessed 7 weeks and 1 year after treatment group assignment. Groups will be compared for differences in self-reported knee function, and in percent loss of tibial cartilage volume on MRI scans from baseline to 1 year. Quadriceps strength deficits will be correlated with peak vertical ground reaction force symmetry during functional activities, and with levels of inflammatory cytokines (TNF-alpha and IL-1beta) in synovial fluid. The career development plan and supervised research experiences will provide the candidate with the necessary research skills for a career as an independent research investigator and fill an important research gap. UF provides an excellent training environment with state-of-the-art facilities and a large number of faculties with an expertise in rehabilitation research.

描述（由申请人提供）：申请人是佛罗里达大学物理治疗系的助理教授。她拥有物理疗法的硕士学位和博士学位。在生物力学和运动科学中。她的目标是成为一名专注于设计和实施多学科临床和翻译调查的独立研究人员，以最大程度地提高功能结果，并降低膝关节受伤患者创伤后骨关节炎（OA）的风险。通过该K01奖，申请人将获得进行临床试验的技能，评估关节软骨形态（MRI）（MRI）以及对关节软骨和炎症生物标记物进行生化分析，以成为独特的交叉培训，并能够进行研究的综合方法来研究膝盖的膝关节。她的委托人Vandenborne博士和Leeuwenburgh博士将通过严格的指导和实践培训，教学课程工作以及参加研讨会和会议，从而帮助她从初级教师到独立调查员的过渡。研究计划的主要目的是确定密集的股四头肌增强对截骨术后功能结果和关节软骨结构的影响。次要目的是检查股后股骨肌强度缺陷与下肢负荷对称性和膝关节炎症程度的关联。基线测试后，有54名半月板切除术的受试者将随机分配到6周的标准康复计划或标准康复计划，并通过强化股四头肌增强（高强度神经肌肉电气刺激和偏心运动）增强。治疗组分配后的7周零1年，将对受试者进行重新评估。将比较自我报告的膝关节功能差异的组，以及从基线到1年的MRI扫描中胫骨软骨量损失的百分比。股四头肌强度缺陷将与功能活性期间峰值垂直地面反作用力对称性以及滑液中炎性细胞因子（TNF-Alpha和IL-1Beta）的水平相关。职业发展计划和监督研究经验将为候选人提供作为独立研究研究者职业的必要研究技能，并填补重要的研究差距。 UF提供了一个出色的培训环境，具有最先进的设施和许多具有康复研究专业知识的能力。