Computer-Based Treatment for Drug Dependence

基于计算机的药物依赖性治疗

• 批准号: 7879264
• 负责人: BRENT A. MOORE
• 金额: $ 18.13万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-15 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7879264
• 关键词: Agonist; Area; Behavior Therapy; Buprenorphine; Cognitive; Cognitive Science; Computer Assisted; Computers; Counseling; Data; Dependence; Development; Disadvantaged; Drug Addiction; Drug abuse; Effectiveness; Evaluation; Generations; Goals; Health Services Accessibility; Heroin; Individual; Intervention; Knowledge; Maintenance; Manuals; Mental Depression; Mental disorders; Methods; Modality; Modification; Opiate Addiction; Opiates; Opioid; Outcome; Patients; Pharmaceutical Preparations; Phase; Physicians; Physicians' Offices; Pilot Projects; Policies; Principal Investigator; Professional counselor; Provider; Psychotherapy; Qualitative Research; Randomized; Research; Research Activity; Research Methodology; Research Personnel; Research Project Grants; Resistance; Resources; Sampling; Services; Substance abuse problem; Surveys; System; Technology; Telephone; Testing; Therapeutic; Therapeutic Uses; Time; Training; Treatment Efficacy; Treatment outcome; United States; Voice; Wages; alternative treatment; base; career; career development; cost; improved; interest; methadone maintenance; novel; opioid abuse; pilot trial; primary care setting; programs; prototype; public health relevance; response; skills; statistics; treatment as usual

DESCRIPTION (provided by applicant): This is a revised application for a K01 to launch an independent research program on the use of Therapeutic Interactive Voice Response (TIVR) and other computer-assisted methods to provide drug counseling to patients receiving office-based buprenorphine maintenance and other drug abuse treatment. This application builds on my expertise in cognitive psychology, computer technologies, drug counseling, drug treatment in primary care settings, and statistics, and takes advantage of the unique resources at Yale. A K01 would provide salary support at a critical juncture in my career, free me up from other projects, and allow me to devote 100% toward becoming an independent investigator. For my training, the K01 would allow me to increase my skills and knowledge in 3 areas: 1) computer based interventions for substance abuse and other psychiatric disorders, 2) the development and evaluation of manual-guided behavioral interventions, and 3) qualitative research methods. For my independent research, I propose to conduct a research project in 3 phases to develop and evaluate a TIVR prototype providing cognitive and behavioral treatment (CBT) to opioid dependent patients receiving buprenorpine maintenance in a primary care setting. The three research phases will involve the generation, testing, and modification of TIVR individual treatment modules. Phase 1 will involve feasibility testing of 10 generated modules across 4 iterations. Phase 2 will compare a single module/session of the TIVR system to an educational video presentation condition and a single therapist-provided session on proximal outcomes of effectiveness among opiate-dependent patients initiating buprenorphine treatment (n = 60). Phase 3 will consist of a pilot trial of TIVR for buprenorphine maintained patients in a primary care setting. Forty patients will be randomly assigned to either TIVR, receiving access to the 10 module prototype for 4 weeks, or to treatment-as-usual. This pilot will provide initial evidence of TIVR efficacy and indicators of the feasibility and acceptability of using TIVR in office-based settings. PUBLIC HEALTH RELEVANCE: Development of an effective, inexpensive, and easily accessible computer based CBT for drug abuse patients in primary care settings would greatly expand and improve available substance abuse services.

描述（由申请人提供）：这是K01的修订申请，以启动有关使用治疗性互动语音反应（TIVR）的独立研究计划（TIVR）和其他计算机辅助方法，以向接受基于办公室的丁丙诺啡维持和其他药物滥用治疗的患者提供药物咨询。该应用基于我在认知心理学，计算机技术，药物咨询，初级保健环境中的药物治疗和统计方面的专业知识，并利用耶鲁大学的独特资源。 K01将在我的职业生涯中的关键时刻提供薪水支持，使我摆脱其他项目，并让我100％致力于成为一名独立的调查员。在我的培训中，K01将使我能够在3个领域提高自己的技能和知识：1）基于计算机的药物滥用和其他精神疾病的干预措施，2）手动指导的行为干预措施的发展和评估，以及3）定性研究方法。对于我的独立研究，我建议在3个阶段进行研究项目，以开发和评估TIVR原型，该原型为阿片类药物依赖的患者提供认知和行为治疗（CBT），并在初级保健环境中接受丁丙诺氨酸。这三个研究阶段将涉及TIVR个体治疗模块的生成，测试和修改。第1阶段将涉及4个迭代中10个生成模块的可行性测试。第2阶段将将TIVR系统的单个模块/会话与教育视频表现条件以及促鸦片依赖性患者的近端结果的单一治疗师提供的会话（n = 60）。第三阶段将包括TIVR试验丁丙诺啡在初级保健环境中维持患者的试验。 40名患者将被随机分配给TIVR，可接收10个模块原型4周，或者是公平的。该飞行员将提供TIVR功效的初步证据以及在基于办公室设置中使用TIVR的可行性和可接受性的指标。 公共卫生相关性：开发有效，廉价且易于使用的基于计算机的CBT用于初级保健环境中的药物滥用患者将大大扩展和改善可用的药物滥用服务。