CORE--Nonhuman Primate Contraceptive

核心——非人类灵长类避孕药

• 批准号: 7799172
• 负责人: Mary B Zelinski
• 金额: $ 44.87万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7799172
• 关键词: Animals; Biological Assay; Blood specimen; Contraceptive Agents; Contraceptive methods; Dose; Drug Kinetics; Event; Female; Hormones; Housing; Human Resources; Individual; Laboratories; Macaca; Menstruation; Monitor; Partner in relationship; Pregnancy; Primates; Protocols documentation; Research Personnel; Services; Swab; Ultrasonography; Vagina; animal resource; investigator training; male; metabolic abnormality assessment; nonhuman primate

1. Objective a. Objective. The Nonhuman Primate Contraceptive Core (NPCC) will provide services and coordination of animal usage for U54 Contraceptive Center investigators with approved projects. The NPCC maintains a pool of cynomolgus macaque females and males available for contraceptive (mating) trials in the Division of Animal Resources (DAR), ONPRC; coordinates and performs studies on potential contraceptive agents; takes vaginal swabs to confirm menstruation and insure mating has occurred; performs ultrasounds to monitor for pregnancies; obtains blood samples for hormone assays, pharmacokinetic studies and metabolic profiles. The Core acclimates the females to a small group (harem) housing situations (10 females to one male) wherein they can be separated for daily vaginal checks, dosing, blood sampling and ultrasound analyses. In addition, the NPCC trains investigators in established protocols and disseminates information on emerging approaches. The NPCC represents an efficient use of animals and personnel, and provides assistance that is prohibitively expensive to establish in individual investigator's laboratories.

1。目标 一个。客观的。非人类灵长类动物避孕核心（NPCC）将提供服务和协调 U54避孕中心调查人员的动物使用情况，并具有批准的项目。 NPCC维护一个池 在动物分裂中可用于避孕试验（交配）试验的Cynomolgus猕猴和雄性 资源（DAR），ONPRC；协调并进行有关潜在避孕剂的研究；阴道 拭子已确认月经和确保交配发生；执行超声检查以监视 怀孕；获得血液样本以进行激素测定，药代动力学研究和代谢谱。这 核心使女性适应一小群（后宫）住房情况（对一个男性10个女性） 它们可以分开进行每日阴道检查，给药，血液采样和超声分析。此外， NPCC培训研究人员已建立的协议，并传播有关新兴方法的信息。 NPCC代表了动物和人员的有效利用，并提供了强烈的援助 在个人调查员的实验室中建立昂贵。