BIOLOGICAL TESTING FACILITY - CONTRACEPTIVE TARGET APPLICATION

生物测试设施 - 避孕目标应用

• 批准号: 10788177
• 负责人: DEBORAH BUNIN
• 金额: $ 19.97万
• 依托单位: SRI INTERNATIONAL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-11-17 至 2023-11-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10788177
• 关键词: Area; Bioinformatics; Biological Testing; Clinical; Clinical Trials; Collaborations; Contraceptive Agents; Contraceptive Availability; Contraceptive Devices; Data; Databases; Development; Devices; Drug Formulations; Evaluation; Friends; In Vitro; Internet; Investigational New Drug Application; Knowledge; Maintenance; Medicine; Pharmaceutical Preparations; Phase; Preparation; Process; Research Personnel; Safety; System; Toxicology; Update; Work; contraceptive target; design; drug discovery; drug testing; efficacy evaluation; in vivo; next generation; novel; novel strategies; pre-clinical; reproductive; stability testing; user-friendly; web app; web site

Early phase non-steroidal contraceptive discovery and development is limited by known targets and readily accessibility of this information. It is important to facilitate the discovery, curation and availability of contraceptive targets with the aim of developing new approaches to advance next generation of safe contraceptive drug/device. To alleviate this obstacle, bioinformatics driven approach to identify and curate those targets from the existing databases was established. To further allow easy accessibility and friendly user interface for this database, a web application is needed. The Biological Testing Facility has bioinformatics and web design and application capability to achieve this task, in addition to permit rapid evaluation (in vitro and in vivo) of new compositions of matter to the target, efficacy evaluation, safety/ toxicology assessment, drug formulations, delivery systems, and devices for contraceptives followed by clinical batch preparation/ release and continued stability testing of drugs to be evaluated in clinical trials. The BTF provides overall project management and the capabilities to support all phases of novel target product identification, drug discovery/ optimization, preclinical activities and development of contraceptives and associated tasks leading to the filing of investigational new drug (IND) applications.

早期非甾体避孕药的发现和开发受到已知目标的限制 并轻松获取这些信息。促进发现、管理非常重要 和避孕目标的可用性，旨在开发新的方法来推进 下一代安全避孕药物/装置。为了缓解这一障碍，生物信息学驱动 建立了从现有数据库中识别和管理这些目标的方法。到 为了进一步允许该数据库轻松访问和友好的用户界面，网络应用程序是 需要。生物检测设施具有生物信息学和网页设计与应用 除了允许快速评估（体外和体内）新的药物之外，还有能力完成这项任务 目标物的成分、功效评估、安全性/毒理学评估、药物 避孕药具的配方、输送系统和装置，然后进行临床批次 临床试验中待评估药物的制备/释放和持续稳定性测试。这 BTF 提供整体项目管理和支持新目标所有阶段的能力 产品鉴定、药物发现/优化、临床前活动和开发 避孕药具和导致研究性新药 (IND) 申请的相关任务 应用程序。