FMRI STUDIES OF EMOTION AND MOVEMENT

情绪和运动的 FMRI 研究

• 批准号: 7795027
• 负责人: Stephen Coombes
• 金额: $ 5.22万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-22 至 2011-03-21
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7795027
• 关键词: Accounting; Affective; Amygdaloid structure; Area; Arts; Basal Ganglia; Behavior; Behavioral; Bipolar Disorder; Brain; Cell Nucleus; Cells; Clinical; Cognitive; Corpus striatum structure; Data; Deep Brain Stimulation; Dopamine; Emotional; Emotional disorder; Emotions; Experimental Designs; Functional Magnetic Resonance Imaging; Generations; Globus Pallidus; Human; Image; Intervention; Isometric Exercise; Knowledge; Measures; Mental disorders; Midbrain structure; Modeling; Motor; Motor Cortex; Movement; Neurobiology; Neurons; Operative Surgical Procedures; Output; Parkinson Disease; Phase; Population; Process; Production; Research; Signal Transduction; Structure; Substantia nigra structure; System; Testing; Thalamic structure; Time; Ventral Striatum; Work; base; blood oxygen level dependent; emotional stimulus; human subject; innovation; motor deficit; motor disorder; neural circuit; neurochemistry; nonhuman primate; putamen; relating to nervous system; research study

DESCRIPTION (provided by applicant): The long term objective of the applicant is to develop a deep understanding of how emotion and motor systems interact at the behavioral, neurobiological, and neurochemical level in the human brain. Recent evidence from studies in non-human primates identifies two integrative mechanisms that allow emotion and motor information to be transferred across parallel cortico-striatal-cortico loops. Specific nuclei within the affective loop (thalamus) and motor loop (substantia nigra) are key components of these integrative mechanisms. Building on the prior work of the applicant the current proposal will, for the first time, test hypotheses derived from these integrative models in the human brain using precise experimental design and state of the art functional magnetic resonance imaging (fMRI) at 3 Tesla. The proposal will determine how force production alters neuronal activity in regions that process emotional information (i.e., affective loop) and how emotional processing alters neuronal activity in regions that process motor information (i.e., motor loop). The proposed studies will measure blood oxygenation level dependent (BOLD) signal change and isometric force output from human subjects while they passively view emotional and neutral images and while they view emotional and neutral images while generating force. The experiments will examine four hypotheses in two specific aims. Aim la tests the hypothesis that viewing emotional images increases activity within all affective loop nuclei. Aim Ib tests the hypothesis that the dorsomedial thalamus will show increased BOLD signal when emotion and motor processes are paired together. Aim 2a tests the hypothesis that force production increases activity within all motor loop nuclei. Aim 2b tests the hypothesis that the substantia nigra will show increased BOLD signal when emotion and motor processes are paired together. Findings generated from this proposal will motivate the next phase of the applicant's long term objective which will be to understand how surgical (deep brain stimulation) and pharmacological (dopamine) interventions alter the functioning of these integrative mechanisms in clinical populations with co-morbid emotional and motor abnormalities (bipolar disorder, Parkinson's disease). Emotional disorders can present with motor deficits, and motor disorders of the basal ganglia can present with emotional deficits. The mechanism in the human brain that integrates emotion and movement remains largely unknown. Understanding the neural circuits that integrate emotion and motor processes will inform interventions that seek to regulate and facilitate emotional and/or motor function.

描述（由申请人提供）：申请人的长期目标是对人脑中的行为，神经生物学和神经化学水平的情绪和运动系统如何相互作用深入了解。来自非人类灵长类动物的研究的最新证据确定了两种综合机制，这些机制允许情绪和运动信息在平行的皮质 - 纹状体 - 纹状体环路上传递。情感环内（丘脑）和运动环（黑质）内的特定核是这些综合机制的关键组成部分。在申请人先前的工作的基础上，当前的建议将首次使用精确的实验设计和3特斯拉的艺术功能磁共振成像（fMRI）的精确实验设计和状态。该提案将决定强迫产生如何改变处理情绪信息（即情感循环）的区域中的神经元活动，以及情绪处理如何改变处理运动信息（即电动机循环）的区域中的神经元活动。提出的研究将测量人类受试者的血液氧合水平依赖性（粗体）信号变化和等距力输出，同时他们会在产生力量的同时查看情绪和中性图像，同时观察情绪和中性图像。实验将在两个特定目标中检查四个假设。 AIM LA检验了以下假设：观看情绪图像会增加所有情感环核中的活动。 AIM IB检验了以下假设：当情绪和运动过程配对时，背部丘脑将显示出大胆的信号。 AIM 2A检验了一个假设，即力产生增加了所有运动环核中的活性。 AIM 2B检验了以下假设：当情绪和运动过程配对时，黑质将显示出大胆的信号。该提案产生的发现将激发申请人长期目标的下一阶段，这将是了解手术（深脑刺激）和药理学（多巴胺）干预如何改变这些综合机制在临床人群中的功能，并具有联合性情绪和运动异常（双极性疾病，帕金森氏病）。情绪障碍可能会出现运动不足，基底神经节的运动障碍会出现情绪缺陷。整合情绪和运动的人类大脑中的机制仍然很大程度上是未知的。了解整合情绪和运动过程的神经回路将为试图调节和促进情绪和/或运动功能的干预措施提供信息。