The Role of Microaspiration in Idiopathic Pulmonary Fibrosis

微抽吸在特发性肺纤维化中的作用

• 批准号: 7922134
• 负责人: Joyce Sujin Lee
• 金额: $ 7.04万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7922134
• 关键词: Accident and Emergency department; Alveolar; Biological; Biological Markers; Body mass index; Bronchoalveolar Lavage; Caring; Chronic; Clinic Visits; Clinical; Clinical Research; Comorbidity; Data; Diagnosis; Diffuse; Disease; Disease Progression; Epithelial; Esophageal; Future; Gastroesophageal reflux disease; Hamman-Rich syndrome; Helicobacter pylori; Hiatal Hernia; Hospitalization; Image; Inflammation; Injury; Irrigation; Laboratories; Lead; Liquid substance; Lung; Lung diseases; Manometry; Measurement; Measures; Medical; Methods; Mission; Monitor; National Heart, Lung, and Blood Institute; Natural History; Neutrophilia; Pathogenesis; Patients; Pepsin A; Play; Population Control; Prevalence; Public Health; Pulmonary Surfactant-Associated Protein D; Quality of life; Research; Research Design; Research Personnel; Research Training; Risk Factors; Role; Serum; Surveys; Testing; Therapeutic; Training; Transplant Recipients; Visit; career development; cohort; disease natural history; effective therapy; gastrointestinal; healthy volunteer; improved; inflammatory marker; pulmonary function; skills; success

DESCRIPTION (provided by applicant): Idiopathic pulmonary fibrosis (IPF) is a uniformly fatal diffuse lung disease with no effective treatment. Emerging data suggest that microaspiration may play a role in the pathogenesis and natural history of IPF. Defining the relationship between microaspiration and IPF could have major pathobiological and therapeutic implications. Objectives and Aims: The long-term objective of this proposal is to define the role of microaspiration in IPF. Aim 1: To determine the prevalence of microaspiration in patients with IPF. Aim 2: To elucidate biomarkers of microaspiration in patients with IPF. Aim 3: To define the impact of microaspiration on disease progression in IPF. Research Design and Methods: This proposal involves a prospectively identified cohort of 30 subjects with IPF. The prevalence of microaspiration in IPF (Aim 1) will be determined by measuring pepsin levels in bronchoaveolar lavage fluid. Biomarkers for microaspiration in IPF (Aim 2) will be identified using esophageal function studies (24h pH monitoring and manometry), laboratory tests, radiological imaging, and survey. The impact of microaspiration on disease progression (Aim 3) will be defined by measuring changes in pulmonary function over 12 months and assessing rates of urgent medical care use (unscheduled clinic visit, emergency room visit, and hospitalization). This proposal is directly relevant to the mission of the NHLBI: "supporting research training and career development of new researchers to enable conduct of clinical research related to diagnosis of lung disease." This proposal includes advanced training in clinical research skills that will provide the necessary skills for future success as an independent clinical researcher. Relevance of Research to Public Health: Idiopathic pulmonary fibrosis (IPF) is a fatal disease without any known treatment or cure. Defining the role of microaspiration in IPF is important because it could lead to effective treatment options. Effective treatment will substantially improve the quality of life and survival of those patients suffering with IPF.

描述（由申请人提供）：特发性肺纤维化（IPF）是一种统一的致命弥漫性肺部疾病，没有有效的治疗。新兴的数据表明，微型诱惑可能在IPF的发病机理和自然历史中起作用。定义微观诱惑与IPF之间的关系可能具有主要的病理学和治疗意义。目标和目的：该提案的长期目标是定义微观余的在IPF中的作用。目的1：确定IPF患者中微型抽血的患病率。目的2：阐明IPF患者中微型诱惑的生物标志物。目的3：定义微观激发对IPF疾病进展的影响。研究设计和方法：该提案涉及30名与IPF受试者的同类同类。 IPF中微观诱惑的患病率（AIM 1）将通过测量支气管液管灌洗液中的胃蛋白酶水平来确定。将使用食管功能研究（24H pH监测和测量法），实验室测试，放射学成像和调查来鉴定用于IPF中微型诱惑的生物标志物（AIM 2）。微观抽血对疾病进展的影响（AIM 3）将通过在12个月内测量肺功能的变化并评估紧急医疗服务的发生率（外诊断，急诊室就诊和住院）来定义。该建议与NHLBI的使命直接相关：“支持新研究人员的研究培训和职业发展，以实现与肺部疾病诊断有关的临床研究。”该建议包括临床研究技能的高级培训，这些培训将为作为独立临床研究人员的未来成功提供必要的技能。研究与公共卫生的相关性：特发性肺纤维化（IPF）是一种致命疾病，没有任何已知的治疗或治愈方法。定义微观激素在IPF中的作用很重要，因为它可能导致有效的治疗选择。有效的治疗将大大改善患有IPF患者的生活质量和生存质量。