Idiographic Examination of Alcohol to Dampen Positive Emotions for Co-morbid Alcohol Use and PTSD

酒精的具体检查可抑制共病酒精使用和创伤后应激障碍的积极情绪

• 批准号: 10730599
• 负责人: Nicole Holland Weiss
• 金额: $ 43万
• 依托单位: UNIVERSITY OF RHODE ISLAND
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-17 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10730599
• 关键词: Address; Adverse reactions; Alcohol consumption; Alcohols; Area; Arousal; Communities; Computer software; Coupled; Cues; Data; Data Collection; Down-Regulation; Ecological momentary assessment; Emotional; Emotions; Environment; Event; Frequencies; Fright; General Practices; Health; Health Priorities; Healthcare; Heterogeneity; Hour; Individual; Intervention; Investigation; Life; Link; Modeling; Motivation; National Institute on Alcohol Abuse and Alcoholism; Negative Reinforcements; Outcome; Participant; Pattern; Personal Satisfaction; Persons; Physiological; Post-Traumatic Stress Disorders; Prevalence; Process; Public Health; Regulation; Reporting; Research; Research Personnel; Risk; Role; Sampling; Severities; Source; Statistical Methods; Stimulus Generalization; Symptoms; Time; Trauma; Typology; Work; alcohol comorbidity; alcohol risk; alcohol use disorder; behavior change; clinically significant; conditioning; early onset; experience; in vivo; innovation; inter-individual variation; positive emotional state; prevent; stem; trauma exposure

PROJECT SUMMARY/ABSTRACT Posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD) co-occur with high frequency (24- 61%). PTSD role have emotions suggest regulation) less via alcohol use. One explanation for these findings is This co-occurrence has considerable clinical significance. Individuals with co-occurring PTSD-AUD (vs. or AUD alone) report more PTSD symptoms and worse alcohol outcomes. Research emphasizes the of emotional processes in the co-occurrence of PTSD and AUD. However, prior investigations in this area been narrow in scope, focusing almost exclusively on negative emotions. The limited research on positive purports a role of alcohol use in up-regulating (eliciting/increasing) positive emotions. Our pilot data that alcohol use among individuals with PTSD symptoms also may be motivated by avoidance (down- of positive emotions . We have found that trauma-exposed individuals with PTSD symptoms are accepting of positive emotions, and more likely to engage in fforts to avoid positive emotions, including that positive emotions elicit physiological e arousal that is linked to trauma-related symptoms and thus evaluated as aversive among individuals with PTSD symptoms. The processes current proposal will leverage intensive l ongitudinal data t o evaluate dynamic and idiographic among positive emotional processes, alcohol use, and PTSD symptoms as they unfold in daily life among trauma-exposed community individuals who regularly drink and experience PTSD symptoms (N=150). Ecological momentary assessment (EMA) will capture momentary processes in real-time & in natural settings, maximizing profiles. ecological validity and generalizability of findings. Idiographic analysis will identify personalized risk These approacheswill provide the necessary data to inform idiographic PTSD-AUD interventions that can be implemented at the microlevel. Aim 1 determines the extent to which PTSD symptoms are related to alcohol use to down-regulate positive emotions at the momentary level. Aim 2 usesidiographic analysis to identifypatterns of alcohol to down-regulate positive emotions in relation to PTSD. An Exploratory Aim assesses whether alcohol use to down-regulate positive emotions is distinct from other motives for alcohol use. The findings of this research have the potential to transform health care practice. General practice is to increase positive emotions in PTSD-AUD intervention. If our pilot work is confirmed, and alcohol use serves to down-regulate positive emotions in those with PTSD symptoms, clinicians may first want to evaluate adverse reactions to positive emotions in PTSD-AUD intervention, and, if indicated, address those concerns. The proposed research utilizes an innovative approach to fill significant gaps regarding mechanisms in co- occurring PTSD-AUD. This work is important, timely, and innovative. Preventing PTSD-AUD among trauma- exposed individuals has important implications for the health and well-being of people in our nation.

项目概要/摘要 创伤后应激障碍（PTSD）和酒精使用障碍（AUD）同时发生的频率很高（24- 61%）。 创伤后应激障碍 角色 有 情绪 建议 规定） 较少的 通过饮酒。对这些发现的一种解释是 这种同时发生具有相当大的临床意义。同时患有 PTSD-AUD 的个体（与 或仅 AUD）报告了更多的 PTSD 症状和更糟糕的酒精后果。研究强调 PTSD 和 AUD 同时发生时的情绪过程。然而，之前在这方面的调查 范围很窄，几乎只关注负面情绪。积极的研究有限 声称饮酒在上调（引发/增加）积极情绪方面发挥着作用。我们的试点数据 患有 PTSD 症状的个体饮酒也可能是出于回避（下调） 的积极情绪。我们发现，患有创伤后应激障碍 (PTSD) 症状的受过创伤的人 接受积极情绪，更有可能努力避免积极情绪，包括 积极的情绪会引发生理反应 e 唤醒即 与创伤相关症状有关，因此在患有 PTSD 症状的个体中被评估为厌恶。 这 流程 当前的提案将利用密集的纵向数据来评估动态和具体情况 日常生活中出现的积极情绪过程、饮酒和创伤后应激障碍症状 经常饮酒并出现 PTSD 症状的遭受创伤的社区个体 (N=150)。 生态瞬时评估（EMA）将实时捕捉自然环境中的瞬时过程， 最大化 配置文件。 研究结果的生态有效性和普遍性。具体分析将识别个性化风险 这些方法将提供必要的数据来指导具体的 PTSD-AUD 干预措施， 可以在微观层面上实施。目标 1 确定 PTSD 症状与以下疾病相关的程度： 使用酒精可以暂时降低积极情绪。目标 2 使用具体分析来 识别酒精模式以下调与 PTSD 相关的积极情绪。探索性目标 评估使用酒精来下调积极情绪是否与其他饮酒动机不同。 这项研究的结果有可能改变医疗保健实践。一般做法是 增加 PTSD-AUD 干预中的积极情绪。如果我们的试点工作得到证实，并且饮酒可以 下调具有 PTSD 症状的积极情绪，临床医生可能首先要评估不良情绪 对 PTSD-AUD 干预中积极情绪的反应，并在有需要时解决这些问题。 拟议的研究利用创新方法来填补合作机制方面的重大空白 发生 PTSD-AUD。这项工作重要、及时且具有创新性。预防创伤中的 PTSD-AUD 暴露的个人对我们国家人民的健康和福祉具有重要影响。